Human_Genes_Functions
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GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

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TP53

Query: TP53 Type: All 20 on this page 80 total Page 4 / 4 PDO SQLite primary
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Gene match type: fts

PPP2R5C

protein phosphatase 2 regulatory subunit B'gamma
ENSG00000078304 matched: TP53
Symbol
PPP2R5C
Gene name
protein phosphatase 2 regulatory subunit B'gamma
Ensembl Gene ID
ENSG00000078304
NCBI Gene ID
5527
Match type
fts
Matched value
TP53

…The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a…, Gene symbol: PPP2R5C Gene name: protein phosphatase 2 regulatory subunit B'gamma Chromosome: 14 Gene type: protein_coding Gene status: Coordinates: 14:101761639-101928953 + Aliases: alias_symbol:B56G; alias_symbol:PR61G;…

Open gene detail Gene result
Gene match type: fts

COPS3

COP9 signalosome subunit 3
ENSG00000141030 matched: TP53
Symbol
COPS3
Gene name
COP9 signalosome subunit 3
Ensembl Gene ID
ENSG00000141030
NCBI Gene ID
8533
Match type
fts
Matched value
TP53

…CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the…, Gene symbol: COPS3 Gene name: COP9 signalosome subunit 3 Chromosome: 17 Gene type: protein_coding Gene status: Coordinates: 17:17244686-17281311 - Aliases: alias_symbol:SGN3; alias_symbol:CSN3; previous_name:COP9 (consti…

Open gene detail Gene result
Gene match type: fts

CHEK1

checkpoint kinase 1
ENSG00000149554 matched: TP53
Symbol
CHEK1
Gene name
checkpoint kinase 1
Ensembl Gene ID
ENSG00000149554
NCBI Gene ID
1111
Match type
fts
Matched value
TP53

…Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of…, Gene symbol: CHEK1 Gene name: checkpoint kinase 1 Chromosome: 11 Gene type: protein_coding Gene status: Coordinates: 11:125625163-125676255 + Aliases: alias_symbol:CHK1; previous_name:CHK1 (checkpoint, S.pombe) homolog; …

Open gene detail Gene result
Gene match type: fts

COP1

COP1 E3 ubiquitin ligase
ENSG00000143207 matched: TP53
Symbol
COP1
Gene name
COP1 E3 ubiquitin ligase
Ensembl Gene ID
ENSG00000143207
NCBI Gene ID
64326
Match type
fts
Matched value
TP53

…Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription…, Gene symbol: COP1 Gene name: COP1 E3 ubiquitin ligase Chromosome: 1 Gene type: protein_coding Gene status: Coordinates: 1:175943861-176207523 - Aliases: alias_symbol:FLJ10416; alias_symbol:RNF200; alias_symbol:FAP78; ali…

Open gene detail Gene result
Gene match type: fts

PERP

p53 apoptosis effector related to PMP22
ENSG00000112378 matched: TP53
Symbol
PERP
Gene name
p53 apoptosis effector related to PMP22
Ensembl Gene ID
ENSG00000112378
NCBI Gene ID
64065
Match type
fts
Matched value
TP53

…alias_symbol:PIGPC1; alias_symbol:dJ496H19.1; alias_symbol:KCP1; alias_symbol:THW; alias_symbol:KRTCAP1; alias_name:keratinocyte associated protein 1; previous_name:PERP, TP53 apoptosis…, Gene symbol: PERP Gene name: p53 apoptosis effector related to PMP22 Chromosome: 6 Gene type: protein_coding Gene status: Coordinates: 6:138015003-138107848 - Aliases: alias_symbol:PIGPC1; alias_symbol:dJ496H19.1; alias_…

Open gene detail Gene result
Gene match type: fts

PEX19

peroxisomal biogenesis factor 19
ENSG00000162735 matched: TP53
Symbol
PEX19
Gene name
peroxisomal biogenesis factor 19
Ensembl Gene ID
ENSG00000162735
NCBI Gene ID
5824
Match type
fts
Matched value
TP53

…results in active degradation of TP53 UniProt locations: Cytoplasm; Peroxisome membrane UniProt…, Gene symbol: PEX19 Gene name: peroxisomal biogenesis factor 19 Chromosome: 1 Gene type: protein_coding Gene status: Coordinates: 1:160266229-160286348 - Aliases: alias_symbol:HK33; alias_symbol:D1S2223E; alias_symbol:PMP…

Open gene detail Gene result
Gene match type: fts

ALDOB

aldolase, fructose-bisphosphate B
ENSG00000136872 matched: TP53
Symbol
ALDOB
Gene name
aldolase, fructose-bisphosphate B
Ensembl Gene ID
ENSG00000136872
NCBI Gene ID
229
Match type
fts
Matched value
TP53

…ternary complex with G6PD and TP53 to inhibit G6PD activity and keep…, Gene symbol: ALDOB Gene name: aldolase, fructose-bisphosphate B Chromosome: 9 Gene type: protein_coding Gene status: Coordinates: 9:101420560-101449664 - Aliases: previous_name:aldolase B, fructose-bisphosphate; ccds_id:…

Open gene detail Gene result
Gene match type: fts

S100A4

S100 calcium binding protein A4
ENSG00000196154 matched: TP53
Symbol
S100A4
Gene name
S100 calcium binding protein A4
Ensembl Gene ID
ENSG00000196154
NCBI Gene ID
6275
Match type
fts
Matched value
TP53

…Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal…, Gene symbol: S100A4 Gene name: S100 calcium binding protein A4 Chromosome: 1 Gene type: protein_coding Gene status: Coordinates: 1:153543613-153552135 - Aliases: alias_symbol:P9KA; alias_symbol:18A2; alias_symbol:PEL98; …

Open gene detail Gene result
Gene match type: fts

TAF1

TATA-box binding protein associated factor 1
ENSG00000147133 matched: TP53
Symbol
TAF1
Gene name
TATA-box binding protein associated factor 1
Ensembl Gene ID
ENSG00000147133
NCBI Gene ID
6872
Match type
fts
Matched value
TP53

…Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659…, Gene symbol: TAF1 Gene name: TATA-box binding protein associated factor 1 Chromosome: X Gene type: protein_coding Gene status: Coordinates: X:71366129-71532374 + Aliases: alias_symbol:NSCL2; alias_symbol:TAFII250; alias_…

Open gene detail Gene result
Gene match type: fts

ING3

inhibitor of growth family member 3
ENSG00000071243 matched: TP53
Symbol
ING3
Gene name
inhibitor of growth family member 3
Ensembl Gene ID
ENSG00000071243
NCBI Gene ID
54556
Match type
fts
Matched value
TP53

…protein that can interact with TP53, inhibit cell growth, and induce apoptosis.…, Gene symbol: ING3 Gene name: inhibitor of growth family member 3 Chromosome: 7 Gene type: protein_coding Gene status: Coordinates: 7:120950718-120977216 + Aliases: alias_symbol:p47ING3; alias_symbol:FLJ20089; alias_symbo…

Open gene detail Gene result
Gene match type: fts

PPM1D

protein phosphatase, Mg2+/Mn2+ dependent 1D
ENSG00000170836 matched: TP53
Symbol
PPM1D
Gene name
protein phosphatase, Mg2+/Mn2+ dependent 1D
Ensembl Gene ID
ENSG00000170836
NCBI Gene ID
8493
Match type
fts
Matched value
TP53

…Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which…, Gene symbol: PPM1D Gene name: protein phosphatase, Mg2+/Mn2+ dependent 1D Chromosome: 17 Gene type: protein_coding Gene status: Coordinates: 17:60599735-60666293 + Aliases: alias_symbol:Wip1; alias_symbol:PP2C-DELTA; ali…

Open gene detail Gene result
Gene match type: fts

ING4

inhibitor of growth family member 4
ENSG00000111653 matched: TP53
Symbol
ING4
Gene name
inhibitor of growth family member 4
Ensembl Gene ID
ENSG00000111653
NCBI Gene ID
51147
Match type
fts
Matched value
TP53

…This protein can bind TP53 and EP300/p300, a component of the histone…, Gene symbol: ING4 Gene name: inhibitor of growth family member 4 Chromosome: 12 Gene type: protein_coding Gene status: Coordinates: 12:6650282-6663180 - Aliases: alias_symbol:p29ING4; alias_symbol:my036; ccds_id:CCDS4481…

Open gene detail Gene result
Gene match type: fts

DHX36

DEAH-box helicase 36
ENSG00000174953 matched: TP53
Symbol
DHX36
Gene name
DEAH-box helicase 36
Ensembl Gene ID
ENSG00000174953
NCBI Gene ID
170506
Match type
fts
Matched value
TP53

…site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing…, Gene symbol: DHX36 Gene name: DEAH-box helicase 36 Chromosome: 3 Gene type: protein_coding Gene status: Coordinates: 3:154271823-154324991 - Aliases: alias_symbol:MLEL1; alias_symbol:KIAA1488; alias_symbol:RHAU; alias_na…

Open gene detail Gene result
Gene match type: fts

RASSF1

Ras association domain family member 1
ENSG00000068028 matched: TP53
Symbol
RASSF1
Gene name
Ras association domain family member 1
Ensembl Gene ID
ENSG00000068028
NCBI Gene ID
11186
Match type
fts
Matched value
TP53

…to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle…, Gene symbol: RASSF1 Gene name: Ras association domain family member 1 Chromosome: 3 Gene type: protein_coding Gene status: Coordinates: 3:50329782-50340980 - Aliases: alias_symbol:NORE2A; alias_symbol:REH3P21; alias_symb…

Open gene detail Gene result
Gene match type: fts

PTTG1

PTTG1 regulator of sister chromatid separation, securin
ENSG00000164611 matched: TP53
Symbol
PTTG1
Gene name
PTTG1 regulator of sister chromatid separation, securin
Ensembl Gene ID
ENSG00000164611
NCBI Gene ID
9232
Match type
fts
Matched value
TP53

…The negative regulation of TP53 may explain the strong transforming capability of…, Gene symbol: PTTG1 Gene name: PTTG1 regulator of sister chromatid separation, securin Chromosome: 5 Gene type: protein_coding Gene status: Coordinates: 5:160421801-160428748 + Aliases: alias_symbol:PTTG; alias_symbol:HPT…

Open gene detail Gene result
Gene match type: fts

PATZ1

POZ/BTB and AT hook containing zinc finger 1
ENSG00000100105 matched: TP53
Symbol
PATZ1
Gene name
POZ/BTB and AT hook containing zinc finger 1
Ensembl Gene ID
ENSG00000100105
NCBI Gene ID
23598
Match type
fts
Matched value
TP53

…Interacts with the TP53 protein to control genes that are important in…, Gene symbol: PATZ1 Gene name: POZ/BTB and AT hook containing zinc finger 1 Chromosome: 22 Gene type: protein_coding Gene status: Coordinates: 22:31325804-31346605 - Aliases: alias_symbol:MAZR; alias_symbol:dJ400N23; alia…

Open gene detail Gene result
Gene match type: fts

USP22

ubiquitin specific peptidase 22
ENSG00000124422 matched: TP53
Symbol
USP22
Gene name
ubiquitin specific peptidase 22
Ensembl Gene ID
ENSG00000124422
NCBI Gene ID
23326
Match type
fts
Matched value
TP53

…Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation…, Gene symbol: USP22 Gene name: ubiquitin specific peptidase 22 Chromosome: 17 Gene type: protein_coding Gene status: Coordinates: 17:20999593-21043760 - Aliases: alias_symbol:KIAA1063; previous_symbol:USP3L; previous_name…

Open gene detail Gene result
Gene match type: fts

COPS5

COP9 signalosome subunit 5
ENSG00000121022 matched: TP53
Symbol
COPS5
Gene name
COP9 signalosome subunit 5
Ensembl Gene ID
ENSG00000121022
NCBI Gene ID
10987
Match type
fts
Matched value
TP53

…CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the…, Gene symbol: COPS5 Gene name: COP9 signalosome subunit 5 Chromosome: 8 Gene type: protein_coding Gene status: Coordinates: 8:67037579-67083783 - Aliases: alias_symbol:JAB1; alias_symbol:SGN5; alias_symbol:MOV-34; alias_s…

Open gene detail Gene result
Gene match type: fts

SESN2

sestrin 2
ENSG00000130766 matched: TP53
Symbol
SESN2
Gene name
sestrin 2
Ensembl Gene ID
ENSG00000130766
NCBI Gene ID
83667
Match type
fts
Matched value
TP53

…May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468…, Gene symbol: SESN2 Gene name: sestrin 2 Chromosome: 1 Gene type: protein_coding Gene status: Coordinates: 1:28259473-28282491 + Aliases: alias_symbol:SES2; alias_symbol:DKFZp761M0212; alias_symbol:HI95; alias_symbol:SEST…

Open gene detail Gene result
Gene match type: fts

CUL7

cullin 7
ENSG00000044090 matched: TP53
Symbol
CUL7
Gene name
cullin 7
Ensembl Gene ID
ENSG00000044090
NCBI Gene ID
9820
Match type
fts
Matched value
TP53

…The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in…, Gene symbol: CUL7 Gene name: cullin 7 Chromosome: 6 Gene type: protein_coding Gene status: Coordinates: 6:43037617-43053943 - Aliases: alias_symbol:dJ20C7.5; previous_symbol:KIAA0076; previous_name:KIAA0076; ccds_id:CCDS…

Open gene detail Gene result
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