Human_Genes_Functions
Local prototype • PDO SQLite primary • read-only query mode • sqlite3 fallback available

Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

ING3

ING3

protein_coding 7 120,950,718 - 120,977,216 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000071243
Gene type
protein_coding
Chromosome
7
Coordinates
120,950,718 - 120,977,216
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

54556 CCDS35497 CCDS5778 ENST00000315870.10 Eaf4 FLJ20089 MEAF4 NM_019071 NM_019071.3 Q9NXR8 p47ING3

Summary

GENCODE gene_type=protein_coding; HGNC symbol=ING3; HGNC name=inhibitor of growth family member 3; alias_count=11; RefSeq=NM_019071; UniProt=Q9NXR8; MANE Select=ENST00000315870.10,NM_019071.3

Source: GENCODE + HGNC complete set

54556 • protein-coding

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q9NXR8 • reviewed

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Inhibitor of growth protein 3 · Nucleus

Q9NXR8 • reviewed

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Inhibitor of growth protein 3 · Nucleus

Q9NXR8 • reviewed

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Inhibitor of growth protein 3 · Nucleus

GO annotations

Biological process
  • GO:0006338 chromatin remodeling (IEA)
  • GO:0045893 positive regulation of DNA-templated transcription (NAS)
  • GO:1905168 positive regulation of double-strand break repair via homologous recombination (IDA)
  • GO:0045944 positive regulation of transcription by RNA polymerase II (NAS)
  • GO:0042981 regulation of apoptotic process (NAS)
  • GO:0051726 regulation of cell cycle (IMP)
  • GO:2000779 regulation of double-strand break repair (NAS)
Cellular component
  • GO:0035267 NuA4 histone acetyltransferase complex (IEA)
  • GO:0035267 NuA4 histone acetyltransferase complex (IDA)
  • GO:0035267 NuA4 histone acetyltransferase complex (IDA)
  • GO:0035267 NuA4 histone acetyltransferase complex (IDA)
  • GO:0035267 NuA4 histone acetyltransferase complex (IBA)
  • GO:0000812 Swr1 complex (IDA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0000786 nucleosome (IDA)
  • GO:0005634 nucleus (IEA)

+ 4 more

Molecular function
  • GO:0043998 histone H2A acetyltransferase activity (IDA)
  • GO:0140002 histone H3K4me3 reader activity (IEA)
  • GO:0140002 histone H3K4me3 reader activity (IDA)
  • GO:0140002 histone H3K4me3 reader activity (IDA)
  • GO:0010485 histone H4 acetyltransferase activity (IDA)
  • GO:0043997 histone H4K12 acetyltransferase activity (IDA)
  • GO:0046972 histone H4K16 acetyltransferase activity (IDA)
  • GO:0043995 histone H4K5 acetyltransferase activity (IDA)
  • GO:0043996 histone H4K8 acetyltransferase activity (IDA)

Representative

Representative transcript
ENST00000445699
Representative protein
ENSP00000395719.1
Representative type
GENCODE_Primary
Candidate count
5

GENCODE Release 50 annotation GTF · transcript.tag=GENCODE_Primary; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000339121 ING3-202 protein_coding not available ENSP00000341697.5 7:120,950,718 - 120,956,980 +
ENST00000445699 ING3-205 protein_coding not available ENSP00000395719.1 7:120,950,718 - 120,956,978 +
ENST00000875858 ING3-207 protein_coding not available ENSP00000545917.1 7:120,950,718 - 120,977,216 +
ENST00000875859 ING3-208 protein_coding not available ENSP00000545918.1 7:120,950,718 - 120,977,216 +
ENST00001101283 ING3-215 protein_coding not available ENSP00000771089.1 7:120,950,718 - 120,956,980 +
ENST00001139303 ING3-217 protein_coding not available ENSP00000806716.1 7:120,950,718 - 120,977,216 +
ENST00001049978 ING3-210 nonsense_mediated_decay not available ENSP00000719795.1 7:120,950,755 - 120,975,653 +
ENST00001049979 ING3-211 nonsense_mediated_decay not available ENSP00000719796.1 7:120,950,776 - 120,975,648 +
ENST00001049980 ING3-212 nonsense_mediated_decay not available ENSP00000719797.1 7:120,950,776 - 120,975,274 +
ENST00000315870 ING3-201 protein_coding not available ENSP00000320566.5 7:120,950,777 - 120,977,216 +
ENST00001077709 ING3-213 nonsense_mediated_decay not available ENSP00000747515.1 7:120,950,778 - 120,975,657 +
ENST00000982596 ING3-209 nonsense_mediated_decay not available ENSP00000652413.1 7:120,950,779 - 120,975,290 +
ENST00001110483 ING3-216 nonsense_mediated_decay not available ENSP00000780288.1 7:120,950,779 - 120,970,480 +
ENST00000427726 ING3-203 nonsense_mediated_decay not available ENSP00000410406.1 7:120,950,785 - 120,975,290 +
ENST00001077710 ING3-214 nonsense_mediated_decay not available ENSP00000747516.1 7:120,950,786 - 120,975,657 +
ENST00000431467 ING3-204 protein_coding not available ENSP00000388506.1 7:120,951,116 - 120,977,216 +
ENST00000497502 ING3-206 retained_intron not available not available 7:120,967,496 - 120,970,880 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.