Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS3

COPS3

protein_coding 17 17,244,686 - 17,281,311 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000141030
Gene type
protein_coding
Chromosome
17
Coordinates
17,244,686 - 17,281,311
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

8533 CCDS11183 CCDS56022 COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) CSN3 ENST00000268717.10 NM_003653 NM_003653.4 Q9UNS2 SGN3

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS3; HGNC name=COP9 signalosome subunit 3; alias_count=13; RefSeq=NM_003653; UniProt=Q9UNS2; MANE Select=ENST00000268717.10,NM_003653.4

Source: GENCODE + HGNC complete set

8533 • protein-coding

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

NCBI Gene

UniProt

Q9UNS2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468)

COP9 signalosome complex subunit 3 · Cytoplasm; Nucleus; Cell junction

Q9UNS2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468)

COP9 signalosome complex subunit 3 · Cytoplasm; Nucleus; Cell junction

GO annotations

Biological process
  • GO:0045618 positive regulation of keratinocyte differentiation (IMP)
  • GO:0000338 protein deneddylation (IDA)
  • GO:0045116 protein neddylation (NAS)
  • GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator (IMP)
  • GO:2000434 regulation of protein neddylation (NAS)
  • GO:0009416 response to light stimulus (TAS)
  • GO:0007165 signal transduction (TAS)
  • GO:0006511 ubiquitin-dependent protein catabolic process (IBA)
Cellular component
  • GO:0008180 COP9 signalosome (IEA)
  • GO:0008180 COP9 signalosome (IEA)
  • GO:0008180 COP9 signalosome (IDA)
  • GO:0008180 COP9 signalosome (IPI)
  • GO:0008180 COP9 signalosome (IBA)
  • GO:0070161 anchoring junction (IEA)
  • GO:0005911 cell-cell junction (IDA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005737 cytoplasm (IDA)

+ 12 more

Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 81 more

Representative

Representative transcript
ENST00000268717
Representative protein
ENSP00000268717.5
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000439936 COPS3-203 protein_coding not available ENSP00000413298.2 17:17,244,686 - 17,280,700 -
ENST00000539941 COPS3-212 protein_coding not available ENSP00000437606.2 17:17,244,686 - 17,280,777 -
ENST00000904391 COPS3-219 protein_coding not available ENSP00000574450.1 17:17,244,686 - 17,281,306 -
ENST00000904392 COPS3-220 protein_coding not available ENSP00000574451.1 17:17,244,686 - 17,281,306 -
ENST00000904393 COPS3-221 protein_coding not available ENSP00000574452.1 17:17,244,686 - 17,281,306 -
ENST00000904394 COPS3-222 protein_coding not available ENSP00000574453.1 17:17,244,686 - 17,281,306 -
ENST00000904395 COPS3-223 protein_coding not available ENSP00000574454.1 17:17,244,686 - 17,281,306 -
ENST00000904396 COPS3-224 protein_coding not available ENSP00000574455.1 17:17,244,686 - 17,281,306 -
ENST00000904397 COPS3-225 protein_coding not available ENSP00000574456.1 17:17,244,686 - 17,281,306 -
ENST00000938830 COPS3-226 protein_coding not available ENSP00000608889.1 17:17,244,686 - 17,281,306 -
ENST00000938831 COPS3-227 protein_coding not available ENSP00000608890.1 17:17,244,686 - 17,281,306 -
ENST00000938832 COPS3-228 protein_coding not available ENSP00000608891.1 17:17,244,686 - 17,281,306 -
ENST00000938833 COPS3-229 protein_coding not available ENSP00000608892.1 17:17,244,686 - 17,281,306 -
ENST00000938834 COPS3-230 protein_coding not available ENSP00000608893.1 17:17,244,686 - 17,281,306 -
ENST00000954594 COPS3-231 protein_coding not available ENSP00000624653.1 17:17,244,686 - 17,281,306 -
ENST00000954595 COPS3-232 protein_coding not available ENSP00000624654.1 17:17,244,686 - 17,281,306 -
ENST00000954596 COPS3-233 protein_coding not available ENSP00000624655.1 17:17,244,686 - 17,281,306 -
ENST00000976980 COPS3-234 protein_coding not available ENSP00000646797.1 17:17,244,686 - 17,281,306 -
ENST00001143492 COPS3-247 protein_coding not available ENSP00000803966.1 17:17,244,686 - 17,281,306 -
ENST00000268717 COPS3-201 protein_coding not available ENSP00000268717.5 17:17,246,616 - 17,281,246 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.