Human_Genes_Functions
Local prototype • PDO SQLite primary • read-only query mode • sqlite3 fallback available

Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

ALDOB

ALDOB

protein_coding 9 101,420,560 - 101,449,664 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000136872
Gene type
protein_coding
Chromosome
9
Coordinates
101,420,560 - 101,449,664
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

229 CCDS6756 ENST00000647789.2 NM_000035 NM_000035.4 P05062 aldolase B, fructose-bisphosphate

Summary

GENCODE gene_type=protein_coding; HGNC symbol=ALDOB; HGNC name=aldolase; alias_count=8; RefSeq=NM_000035; UniProt=P05062; MANE Select=ENST00000647789.2,NM_000035.4

Source: GENCODE + HGNC complete set

229 • protein-coding

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

NCBI Gene

UniProt

P05062 • reviewed

Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)

Fructose-bisphosphate aldolase B · Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite · EC 4.1.2.13

P05062 • reviewed

Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)

Fructose-bisphosphate aldolase B · Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite · EC 4.1.2.13

P05062 • reviewed

Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)

Fructose-bisphosphate aldolase B · Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite · EC 4.1.2.13

GO annotations

Biological process
  • GO:0061621 canonical glycolysis (TAS)
  • GO:0030388 fructose 1,6-bisphosphate metabolic process (IEA)
  • GO:0030388 fructose 1,6-bisphosphate metabolic process (IDA)
  • GO:0030388 fructose 1,6-bisphosphate metabolic process (IDA)
  • GO:0030388 fructose 1,6-bisphosphate metabolic process (IBA)
  • GO:0006001 fructose catabolic process (IEA)
  • GO:0006001 fructose catabolic process (IEA)
  • GO:0006000 fructose metabolic process (IEA)
  • GO:0006000 fructose metabolic process (IEA)
  • GO:0006000 fructose metabolic process (IMP)

+ 10 more

Cellular component
  • GO:0034451 centriolar satellite (IEA)
  • GO:0034451 centriolar satellite (IDA)
  • GO:0005829 cytosol (IEA)
  • GO:0005829 cytosol (IEA)
  • GO:0005829 cytosol (IDA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (IBA)

+ 2 more

Molecular function
  • GO:0051117 ATPase binding (IDA)
  • GO:0008092 cytoskeletal protein binding (IDA)
  • GO:0070061 fructose binding (IEA)
  • GO:0070061 fructose binding (IMP)
  • GO:0061609 fructose-1-phosphate aldolase activity (IEA)
  • GO:0061609 fructose-1-phosphate aldolase activity (IEA)
  • GO:0061609 fructose-1-phosphate aldolase activity (IDA)
  • GO:0061609 fructose-1-phosphate aldolase activity (EXP)
  • GO:0061609 fructose-1-phosphate aldolase activity (EXP)
  • GO:0061609 fructose-1-phosphate aldolase activity (IDA)

+ 28 more

Representative

Representative transcript
ENST00000647789
Representative protein
ENSP00000497767.1
Representative type
CCDS
Candidate count
17

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=NA

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000647789 ALDOB-202 protein_coding not available ENSP00000497767.1 9:101,420,560 - 101,435,774 -
ENST00000999667 ALDOB-228 protein_coding not available ENSP00000669484.1 9:101,420,575 - 101,435,823 -
ENST00000903777 ALDOB-211 protein_coding not available ENSP00000573836.1 9:101,420,872 - 101,443,526 -
ENST00000999664 ALDOB-226 nonsense_mediated_decay not available ENSP00000669481.1 9:101,421,049 - 101,442,475 -
ENST00000903776 ALDOB-210 protein_coding not available ENSP00000573835.1 9:101,421,371 - 101,445,540 -
ENST00000903781 ALDOB-215 protein_coding not available ENSP00000573840.1 9:101,421,371 - 101,435,823 -
ENST00000903782 ALDOB-216 protein_coding not available ENSP00000573841.1 9:101,421,373 - 101,435,823 -
ENST00000903791 ALDOB-225 protein_coding not available ENSP00000573850.1 9:101,421,376 - 101,432,346 -
ENST00000903778 ALDOB-212 protein_coding not available ENSP00000573837.1 9:101,421,377 - 101,443,526 -
ENST00000903779 ALDOB-213 protein_coding not available ENSP00000573838.1 9:101,421,377 - 101,442,535 -
ENST00000903783 ALDOB-217 protein_coding not available ENSP00000573842.1 9:101,421,377 - 101,435,823 -
ENST00000903784 ALDOB-218 protein_coding not available ENSP00000573843.1 9:101,421,377 - 101,435,823 -
ENST00000903785 ALDOB-219 protein_coding not available ENSP00000573844.1 9:101,421,377 - 101,435,823 -
ENST00000903788 ALDOB-222 protein_coding not available ENSP00000573847.1 9:101,421,377 - 101,435,355 -
ENST00000903790 ALDOB-224 protein_coding not available ENSP00000573849.1 9:101,421,377 - 101,432,639 -
ENST00000999669 ALDOB-229 nonsense_mediated_decay not available ENSP00000669486.1 9:101,421,377 - 101,435,836 -
ENST00000999670 ALDOB-230 nonsense_mediated_decay not available ENSP00000669487.1 9:101,421,377 - 101,435,823 -
ENST00000999671 ALDOB-231 nonsense_mediated_decay not available ENSP00000669488.1 9:101,421,377 - 101,435,823 -
ENST00000999672 ALDOB-232 protein_coding not available ENSP00000669489.1 9:101,421,377 - 101,435,823 -
ENST00000999673 ALDOB-233 protein_coding not available ENSP00000669490.1 9:101,421,377 - 101,435,823 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.