Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PPP2R5C

PPP2R5C

protein_coding 14 101,761,639 - 101,928,953 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000078304

Gene type
protein_coding

Chromosome
14

Coordinates
101,761,639 - 101,928,953

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

5527 B56G B56gamma CCDS45163 CCDS53911 CCDS53912 CCDS91934 CCDS9964 CCDS9965 ENST00000694906.1 NM_001352913.2 NM_002719 PR61G Q13362 protein phosphatase 2, regulatory subunit B (B56), gamma isoform serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PPP2R5C; HGNC name=protein phosphatase 2 regulatory subunit B'gamma; alias_count=18; RefSeq=NM_002719; UniProt=Q13362; MANE Select=ENST00000694906.1,NM_001352913.2

Source: GENCODE + HGNC complete set

5527 • protein-coding

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q13362 • reviewed

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform · Nucleus; Chromosome, centromere

Q13362 • reviewed

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform · Nucleus; Chromosome, centromere

Q13362 • reviewed

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform · Nucleus; Chromosome, centromere

Q13362 • reviewed

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform · Nucleus; Chromosome, centromere

Q13362 • reviewed

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform · Nucleus; Chromosome, centromere

GO annotations

Biological process

GO:0030330 DNA damage response, signal transduction by p53 class mediator (IDA)
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (IMP)
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (IMP)
GO:0051177 meiotic sister chromatid cohesion (IBA)
GO:0008285 negative regulation of cell population proliferation (IDA)
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process (IMP)
GO:0007165 signal transduction (IEA)
GO:0007165 signal transduction (NAS)

Cellular component

GO:0000775 chromosome, centromeric region (IEA)
GO:0000775 chromosome, centromeric region (IDA)
GO:0005829 cytosol (IEA)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (IBA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (IEA)
GO:0005654 nucleoplasm (TAS)

+ 11 more

Molecular function

GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 35 more

Representative

Representative transcript
ENST00000334743

Representative protein
ENSP00000333905.4

Representative type
CCDS

Candidate count
10

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00001029437	PPP2R5C-238	nonsense_mediated_decay	not available	ENSP00000699254.1	14:101,761,639 - 101,928,953 +
ENST00000328724	PPP2R5C-201	protein_coding	not available	ENSP00000329009.5	14:101,761,644 - 101,928,946 +
ENST00000422945	PPP2R5C-204	protein_coding	not available	ENSP00000412324.2	14:101,761,644 - 101,928,946 +
ENST00000554442	PPP2R5C-212	protein_coding	not available	ENSP00000450525.1	14:101,761,644 - 101,836,573 +
ENST00000556260	PPP2R5C-218	protein_coding	not available	ENSP00000454035.1	14:101,761,644 - 101,767,049 +
ENST00000956808	PPP2R5C-234	protein_coding	not available	ENSP00000626867.1	14:101,761,644 - 101,928,946 +
ENST00000956809	PPP2R5C-235	protein_coding	not available	ENSP00000626868.1	14:101,761,644 - 101,928,946 +
ENST00000956810	PPP2R5C-236	protein_coding	not available	ENSP00000626869.1	14:101,761,644 - 101,928,946 +
ENST00001000984	PPP2R5C-237	protein_coding	not available	ENSP00000670801.1	14:101,761,644 - 101,912,623 +
ENST00001029451	PPP2R5C-247	protein_coding	not available	ENSP00000699268.1	14:101,761,644 - 101,906,646 +
ENST00001113541	PPP2R5C-249	protein_coding	not available	ENSP00000783346.1	14:101,761,644 - 101,910,396 +
ENST00001125390	PPP2R5C-250	protein_coding	not available	ENSP00000795195.1	14:101,761,644 - 101,928,946 +
ENST00001125392	PPP2R5C-252	protein_coding	not available	ENSP00000795197.1	14:101,761,644 - 101,923,407 +
ENST00001125393	PPP2R5C-253	protein_coding	not available	ENSP00000795198.1	14:101,761,644 - 101,838,469 +
ENST00001133959	PPP2R5C-254	protein_coding	not available	ENSP00000815648.1	14:101,761,644 - 101,928,946 +
ENST00001029447	PPP2R5C-244	nonsense_mediated_decay	not available	ENSP00000699264.1	14:101,761,647 - 101,912,629 +
ENST00001029438	PPP2R5C-239	nonsense_mediated_decay	not available	ENSP00000699255.1	14:101,761,652 - 101,928,432 +
ENST00001029441	PPP2R5C-240	nonsense_mediated_decay	not available	ENSP00000699258.1	14:101,761,657 - 101,927,738 +
ENST00001029450	PPP2R5C-246	nonsense_mediated_decay	not available	ENSP00000699267.1	14:101,761,661 - 101,906,665 +
ENST00001029442	PPP2R5C-241	nonsense_mediated_decay	not available	ENSP00000699259.1	14:101,761,669 - 101,927,739 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.