Human_Genes_Functions
Local prototype • PDO SQLite primary • read-only query mode • sqlite3 fallback available

Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COP1

COP1

protein_coding 1 175,943,861 - 176,207,523 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000143207
Gene type
protein_coding
Chromosome
1
Coordinates
175,943,861 - 176,207,523
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

64326 CCDS30944 CCDS44279 CFAP78 ENST00000367669.8 FAP78 FLJ10416 NM_022457 NM_022457.7 Q8NHY2 RFWD2 RNF200 constitutive photomorphogenic protein 1 (Arabidopsis) ring finger and WD repeat domain 2

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COP1; HGNC name=COP1 E3 ubiquitin ligase; alias_count=14; RefSeq=NM_022457; UniProt=Q8NHY2; MANE Select=ENST00000367669.8,NM_022457.7

Source: GENCODE + HGNC complete set

64326 • protein-coding

Alliance of Genome Resources Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q8NHY2 • reviewed

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable)

E3 ubiquitin-protein ligase COP1 · Nucleus speckle; Cytoplasm · EC 2.3.2.27

Q8NHY2 • reviewed

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable)

E3 ubiquitin-protein ligase COP1 · Nucleus speckle; Cytoplasm · EC 2.3.2.27

Q8NHY2 • reviewed

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable)

E3 ubiquitin-protein ligase COP1 · Nucleus speckle; Cytoplasm · EC 2.3.2.27

GO annotations

Biological process
  • GO:0045717 negative regulation of fatty acid biosynthetic process (IMP)
  • GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IMP)
  • GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process (IMP)
  • GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)
  • GO:0016567 protein ubiquitination (IEA)
  • GO:0010212 response to ionizing radiation (IDA)
  • GO:0006511 ubiquitin-dependent protein catabolic process (IMP)
Cellular component
  • GO:0031464 Cul4A-RING E3 ubiquitin ligase complex (IDA)
  • GO:0000139 Golgi membrane (IEA)
  • GO:0005737 cytoplasm (IC)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0016607 nuclear speck (IEA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)

+ 6 more

Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 9 more

Representative

Representative transcript
ENST00000308769
Representative protein
ENSP00000310943.8
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00001005341 COP1-248 nonsense_mediated_decay not available ENSP00000675158.1 1:175,943,861 - 176,207,286 -
ENST00001005342 COP1-249 nonsense_mediated_decay not available ENSP00000675159.1 1:175,943,884 - 176,207,244 -
ENST00001014281 COP1-261 nonsense_mediated_decay not available ENSP00000684098.1 1:175,943,884 - 176,207,262 -
ENST00000896356 COP1-212 protein_coding not available ENSP00000566415.1 1:175,944,828 - 176,207,523 -
ENST00000896357 COP1-213 protein_coding not available ENSP00000566416.1 1:175,944,828 - 176,207,523 -
ENST00000896358 COP1-214 protein_coding not available ENSP00000566417.1 1:175,944,828 - 176,207,523 -
ENST00000896359 COP1-215 protein_coding not available ENSP00000566418.1 1:175,944,828 - 176,207,523 -
ENST00000896360 COP1-216 protein_coding not available ENSP00000566419.1 1:175,944,828 - 176,207,523 -
ENST00000896361 COP1-217 protein_coding not available ENSP00000566420.1 1:175,944,828 - 176,207,523 -
ENST00000896362 COP1-218 protein_coding not available ENSP00000566421.1 1:175,944,828 - 176,207,523 -
ENST00000896363 COP1-219 protein_coding not available ENSP00000566422.1 1:175,944,828 - 176,207,523 -
ENST00000896364 COP1-220 protein_coding not available ENSP00000566423.1 1:175,944,828 - 176,207,523 -
ENST00000896365 COP1-221 protein_coding not available ENSP00000566424.1 1:175,944,828 - 176,207,523 -
ENST00000896366 COP1-222 protein_coding not available ENSP00000566425.1 1:175,944,828 - 176,207,523 -
ENST00000896367 COP1-223 protein_coding not available ENSP00000566426.1 1:175,944,828 - 176,207,523 -
ENST00000896368 COP1-224 protein_coding not available ENSP00000566427.1 1:175,944,828 - 176,207,523 -
ENST00000896369 COP1-225 protein_coding not available ENSP00000566428.1 1:175,944,828 - 176,207,523 -
ENST00000896370 COP1-226 protein_coding not available ENSP00000566429.1 1:175,944,828 - 176,207,523 -
ENST00000896371 COP1-227 protein_coding not available ENSP00000566430.1 1:175,944,828 - 176,207,523 -
ENST00000896372 COP1-228 protein_coding not available ENSP00000566431.1 1:175,944,828 - 176,207,523 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.