Human_Genes_Functions
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Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

S100A4

S100A4

protein_coding 1 153,543,613 - 153,552,135 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000196154
Gene type
protein_coding
Chromosome
1
Coordinates
153,543,613 - 153,552,135
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

18A2 42A 6275 CAPL CCDS1042 ENST00000368716.9 FSP1 MTS1 NM_002961 NM_002961.3 P26447 P9KA PEL98 S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) calcium placental protein calvasculin fibroblast-specific protein-1 metastasin 1 murine placental homolog

Summary

GENCODE gene_type=protein_coding; HGNC symbol=S100A4; HGNC name=S100 calcium binding protein A4; alias_count=21; RefSeq=NM_002961; UniProt=P26447; MANE Select=ENST00000368716.9,NM_002961.3

Source: GENCODE + HGNC complete set

6275 • protein-coding

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

P26447 • reviewed

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:26654597, PubMed:30713770)

Protein S100-A4 · Secreted; Nucleus; Cytoplasm

P26447 • reviewed

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:26654597, PubMed:30713770)

Protein S100-A4 · Secreted; Nucleus; Cytoplasm

P26447 • reviewed

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:26654597, PubMed:30713770)

Protein S100-A4 · Secreted; Nucleus; Cytoplasm

P26447 • reviewed

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:26654597, PubMed:30713770)

Protein S100-A4 · Secreted; Nucleus; Cytoplasm

GO annotations

Biological process
  • GO:0001837 epithelial to mesenchymal transition (TAS)
  • GO:0050918 positive chemotaxis (IEA)
  • GO:0043123 positive regulation of canonical NF-kappaB signal transduction (IDA)
  • GO:0043123 positive regulation of canonical NF-kappaB signal transduction (IBA)
Cellular component
  • GO:0005737 cytoplasm (ISS)
  • GO:0005737 cytoplasm (IEA)
  • GO:0070062 extracellular exosome (HDA)
  • GO:0031012 extracellular matrix (HDA)
  • GO:0005576 extracellular region (IEA)
  • GO:0005576 extracellular region (HDA)
  • GO:0005576 extracellular region (HDA)
  • GO:0005576 extracellular region (EXP)
  • GO:0005576 extracellular region (HDA)
  • GO:0005576 extracellular region (EXP)

+ 9 more

Molecular function
  • GO:0050786 RAGE receptor binding (IPI)
  • GO:0050786 RAGE receptor binding (IBA)
  • GO:0003723 RNA binding (HDA)
  • GO:0003779 actin binding (IEA)
  • GO:0005509 calcium ion binding (IEA)
  • GO:0005509 calcium ion binding (IEA)
  • GO:0005509 calcium ion binding (IEA)
  • GO:0005509 calcium ion binding (TAS)
  • GO:0005509 calcium ion binding (IBA)
  • GO:0048306 calcium-dependent protein binding (IEA)

+ 39 more

Representative

Representative transcript
ENST00000354332
Representative protein
ENSP00000346294.4
Representative type
CCDS
Candidate count
19

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000354332 S100A4-201 protein_coding not available ENSP00000346294.4 1:153,543,613 - 153,545,994 -
ENST00000368714 S100A4-202 protein_coding not available ENSP00000357703.1 1:153,543,613 - 153,550,151 -
ENST00000368715 S100A4-203 protein_coding not available ENSP00000357704.1 1:153,543,613 - 153,545,145 -
ENST00000468373 S100A4-205 protein_coding_CDS_not_defined not available not available 1:153,543,613 - 153,545,806 -
ENST00000481009 S100A4-206 protein_coding_CDS_not_defined not available not available 1:153,543,613 - 153,545,097 -
ENST00000854969 S100A4-207 protein_coding not available ENSP00000525028.1 1:153,543,613 - 153,545,994 -
ENST00000854970 S100A4-208 protein_coding not available ENSP00000525029.1 1:153,543,613 - 153,545,806 -
ENST00000854972 S100A4-210 protein_coding not available ENSP00000525031.1 1:153,543,613 - 153,545,806 -
ENST00000854973 S100A4-211 protein_coding not available ENSP00000525032.1 1:153,543,613 - 153,545,765 -
ENST00000854974 S100A4-212 protein_coding not available ENSP00000525033.1 1:153,543,613 - 153,545,407 -
ENST00000942410 S100A4-213 protein_coding not available ENSP00000612469.1 1:153,543,613 - 153,545,806 -
ENST00000942412 S100A4-215 protein_coding not available ENSP00000612471.1 1:153,543,613 - 153,545,994 -
ENST00000942413 S100A4-216 protein_coding not available ENSP00000612472.1 1:153,543,613 - 153,545,806 -
ENST00001004949 S100A4-217 protein_coding not available ENSP00000674766.1 1:153,543,613 - 153,549,288 -
ENST00001035810 S100A4-222 protein_coding not available ENSP00000705627.1 1:153,543,613 - 153,545,994 -
ENST00001077148 S100A4-224 protein_coding not available ENSP00000746954.1 1:153,543,613 - 153,545,994 -
ENST00001100081 S100A4-225 protein_coding not available ENSP00000769887.1 1:153,543,613 - 153,552,135 -
ENST00001100082 S100A4-226 protein_coding not available ENSP00000769888.1 1:153,543,613 - 153,545,994 -
ENST00001100084 S100A4-228 protein_coding not available ENSP00000769890.1 1:153,543,613 - 153,545,994 -
ENST00001100085 S100A4-229 protein_coding not available ENSP00000769891.1 1:153,543,613 - 153,545,994 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.