Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS5

protein_coding 8 67,037,579 - 67,083,783 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000121022

Gene type
protein_coding

Chromosome
8

Coordinates
67,037,579 - 67,083,783

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

10987 CCDS6198 COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) CSN5 ENST00000357849.9 JAB1 MOV-34 NM_006837 NM_006837.3 Q92905 SGN5

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS5; HGNC name=COP9 signalosome subunit 5; alias_count=14; RefSeq=NM_006837; UniProt=Q92905; MANE Select=ENST00000357849.9,NM_006837.3

Source: GENCODE + HGNC complete set

10987 • protein-coding

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q92905 • reviewed

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2

COP9 signalosome complex subunit 5 · Cytoplasm, cytosol; Nucleus; Cytoplasm, perinuclear region; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle

GO annotations

Biological process

GO:1990182 exosomal secretion (IDA)
GO:0043066 negative regulation of apoptotic process (IMP)
GO:0045944 positive regulation of transcription by RNA polymerase II (IDA)
GO:0043687 post-translational protein modification (TAS)
GO:0000338 protein deneddylation (IDA)
GO:0000338 protein deneddylation (IMP)
GO:0045116 protein neddylation (NAS)
GO:1903894 regulation of IRE1-mediated unfolded protein response (IMP)
GO:0046328 regulation of JNK cascade (IDA)
GO:0051726 regulation of cell cycle (IBA)

+ 3 more

Cellular component

GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IPI)
GO:0008180 COP9 signalosome (IBA)
GO:0000785 chromatin (IDA)
GO:0005737 cytoplasm (IDA)
GO:0005737 cytoplasm (IDA)
GO:0005737 cytoplasm (IDA)

+ 22 more

Molecular function

GO:0019784 deNEDDylase activity (TAS)
GO:0019784 deNEDDylase activity (IBA)
GO:0101005 deubiquitinase activity (TAS)
GO:0019899 enzyme binding (IEA)
GO:0035718 macrophage migration inhibitory factor binding (IEA)
GO:0140492 metal-dependent deubiquitinase activity (IEA)
GO:0140492 metal-dependent deubiquitinase activity (IDA)
GO:0008237 metallopeptidase activity (IEA)
GO:0008237 metallopeptidase activity (IMP)
GO:0008237 metallopeptidase activity (IBA)

+ 55 more

Representative

Representative transcript
ENST00000357849

Representative protein
ENSP00000350512.4

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00001113477	COPS5-227	protein_coding	not available	ENSP00000783282.1	8:67,037,579 - 67,062,145 -
ENST00000357849	COPS5-201	protein_coding	not available	ENSP00000350512.4	8:67,043,079 - 67,062,133 -
ENST00000517736	COPS5-203	protein_coding	not available	ENSP00000429774.1	8:67,043,079 - 67,064,943 -
ENST00000521509	COPS5-211	retained_intron	not available	not available	8:67,043,079 - 67,062,336 -
ENST00000523086	COPS5-212	protein_coding_CDS_not_defined	not available	not available	8:67,043,079 - 67,056,560 -
ENST00000887420	COPS5-214	protein_coding	not available	ENSP00000557479.1	8:67,043,079 - 67,062,145 -
ENST00001016990	COPS5-219	protein_coding	not available	ENSP00000686807.1	8:67,043,079 - 67,062,145 -
ENST00001016991	COPS5-220	nonsense_mediated_decay	not available	ENSP00000686808.1	8:67,043,079 - 67,062,139 -
ENST00001016993	COPS5-222	nonsense_mediated_decay	not available	ENSP00000686810.1	8:67,043,079 - 67,062,129 -
ENST00001066583	COPS5-224	nonsense_mediated_decay	not available	ENSP00000736389.1	8:67,043,079 - 67,062,132 -
ENST00001101703	COPS5-225	nonsense_mediated_decay	not available	ENSP00000771509.1	8:67,043,079 - 67,062,151 -
ENST00001101704	COPS5-226	protein_coding	not available	ENSP00000771510.1	8:67,043,079 - 67,062,145 -
ENST00001133077	COPS5-228	protein_coding	not available	ENSP00000808604.1	8:67,043,079 - 67,062,145 -
ENST00000518374	COPS5-205	nonsense_mediated_decay	not available	ENSP00000427869.1	8:67,043,082 - 67,062,323 -
ENST00000521386	COPS5-210	retained_intron	not available	not available	8:67,043,082 - 67,061,629 -
ENST00001016992	COPS5-221	nonsense_mediated_decay	not available	ENSP00000686809.1	8:67,043,082 - 67,062,140 -
ENST00000960083	COPS5-215	protein_coding	not available	ENSP00000630142.1	8:67,043,083 - 67,062,145 -
ENST00000983241	COPS5-217	protein_coding	not available	ENSP00000653058.1	8:67,043,083 - 67,062,145 -
ENST00000983242	COPS5-218	protein_coding	not available	ENSP00000653059.1	8:67,043,083 - 67,062,145 -
ENST00000983240	COPS5-216	nonsense_mediated_decay	not available	ENSP00000653057.1	8:67,043,088 - 67,062,154 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.