Human_Genes_Functions
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Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PTTG1

PTTG1

protein_coding 5 160,421,801 - 160,428,748 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000164611
Gene type
protein_coding
Chromosome
5
Coordinates
160,421,801 - 160,428,748
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

9232 CCDS4353 EAP1 ECRAR ENST00000352433.10 ESP1-associated protein 1 HPTTG NM_004219 NM_004219.4 O95997 PTTG TUTR1 endogenous cardiac regeneration-associated regulator pituitary tumor-transforming 1 securin tumor-transforming protein 1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PTTG1; HGNC name=PTTG1 regulator of sister chromatid separation; alias_count=16; RefSeq=NM_004219; UniProt=O95997; MANE Select=ENST00000352433.10,NM_004219.4

Source: GENCODE + HGNC complete set

9232 • protein-coding

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

NCBI Gene

UniProt

O95997 • reviewed

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation

Securin · Cytoplasm; Nucleus

O95997 • reviewed

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation

Securin · Cytoplasm; Nucleus

O95997 • reviewed

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation

Securin · Cytoplasm; Nucleus

GO annotations

Biological process
  • GO:0051276 chromosome organization (IEA)
  • GO:0045143 homologous chromosome segregation (IBA)
  • GO:0034090 maintenance of meiotic sister chromatid cohesion (NAS)
  • GO:0034088 maintenance of mitotic sister chromatid cohesion (NAS)
  • GO:0007283 spermatogenesis (TAS)
Cellular component
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (TAS)
  • GO:0005829 cytosol (IDA)
  • GO:0005829 cytosol (IDA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 8 more

Molecular function
  • GO:0004869 cysteine-type endopeptidase inhibitor activity (NAS)
  • GO:0004869 cysteine-type endopeptidase inhibitor activity (IBA)
  • GO:0140677 molecular function activator activity (EXP)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000352433
Representative protein
ENSP00000344936.5
Representative type
CCDS
Candidate count
10

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000922252 PTTG1-208 protein_coding not available ENSP00000592311.1 5:160,421,801 - 160,428,748 +
ENST00000922253 PTTG1-209 protein_coding not available ENSP00000592312.1 5:160,421,801 - 160,428,748 +
ENST00000922254 PTTG1-210 protein_coding not available ENSP00000592313.1 5:160,421,801 - 160,428,748 +
ENST00000922255 PTTG1-211 protein_coding not available ENSP00000592314.1 5:160,421,801 - 160,428,748 +
ENST00000922256 PTTG1-212 protein_coding not available ENSP00000592315.1 5:160,421,801 - 160,428,748 +
ENST00000922257 PTTG1-213 protein_coding not available ENSP00000592316.1 5:160,421,801 - 160,428,748 +
ENST00000922258 PTTG1-214 protein_coding not available ENSP00000592317.1 5:160,421,801 - 160,428,748 +
ENST00000922259 PTTG1-215 protein_coding not available ENSP00000592318.1 5:160,421,801 - 160,428,748 +
ENST00001102581 PTTG1-228 protein_coding not available ENSP00000772387.1 5:160,421,801 - 160,428,748 +
ENST00001102582 PTTG1-229 protein_coding not available ENSP00000772388.1 5:160,421,801 - 160,428,748 +
ENST00001102583 PTTG1-230 protein_coding not available ENSP00000772389.1 5:160,421,801 - 160,428,740 +
ENST00001139410 PTTG1-231 protein_coding not available ENSP00000808162.1 5:160,421,801 - 160,428,748 +
ENST00001066616 PTTG1-222 nonsense_mediated_decay not available ENSP00000736422.1 5:160,421,817 - 160,428,742 +
ENST00001066617 PTTG1-223 protein_coding not available ENSP00000736423.1 5:160,421,819 - 160,428,748 +
ENST00001066626 PTTG1-224 nonsense_mediated_decay not available ENSP00000736432.1 5:160,421,834 - 160,428,739 +
ENST00001066627 PTTG1-225 nonsense_mediated_decay not available ENSP00000736433.1 5:160,421,836 - 160,428,740 +
ENST00001055694 PTTG1-221 nonsense_mediated_decay not available ENSP00000725511.1 5:160,421,852 - 160,428,738 +
ENST00000352433 PTTG1-201 protein_coding not available ENSP00000344936.5 5:160,421,855 - 160,428,739 +
ENST00000524244 PTTG1-207 retained_intron not available not available 5:160,421,855 - 160,423,003 +
ENST00001066630 PTTG1-226 nonsense_mediated_decay not available ENSP00000736436.1 5:160,421,855 - 160,428,740 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.