Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

ING4

ING4

protein_coding 12 6,650,282 - 6,663,180 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000111653
Gene type
protein_coding
Chromosome
12
Coordinates
6,650,282 - 6,663,180
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

51147 CCDS44812 CCDS44813 CCDS44814 CCDS44815 CCDS44816 CCDS8555 ENST00000341550.9 NM_016162.4 NM_198287 Q9UNL4 my036 p29ING4

Summary

GENCODE gene_type=protein_coding; HGNC symbol=ING4; HGNC name=inhibitor of growth family member 4; alias_count=13; RefSeq=NM_198287; UniProt=Q9UNL4; MANE Select=ENST00000341550.9,NM_016162.4

Source: GENCODE + HGNC complete set

51147 • protein-coding

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q9UNL4 • reviewed

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

Inhibitor of growth protein 4 · Nucleus

Q9UNL4 • reviewed

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

Inhibitor of growth protein 4 · Nucleus

Q9UNL4 • reviewed

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

Inhibitor of growth protein 4 · Nucleus

Q9UNL4 • reviewed

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

Inhibitor of growth protein 4 · Nucleus

Q9UNL4 • reviewed

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

Inhibitor of growth protein 4 · Nucleus

Q9UNL4 • reviewed

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

Inhibitor of growth protein 4 · Nucleus

GO annotations

Biological process
  • GO:0140889 DNA replication-dependent chromatin disassembly (IEA)
  • GO:0140889 DNA replication-dependent chromatin disassembly (IDA)
  • GO:0006338 chromatin remodeling (IEA)
  • GO:0045892 negative regulation of DNA-templated transcription (IDA)
  • GO:0008285 negative regulation of cell population proliferation (IDA)
  • GO:0008285 negative regulation of cell population proliferation (IDA)
  • GO:0045926 negative regulation of growth (IDA)
  • GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator (IDA)
  • GO:0045893 positive regulation of DNA-templated transcription (IEA)
  • GO:0043065 positive regulation of apoptotic process (IEA)

+ 8 more

Cellular component
  • GO:0000123 histone acetyltransferase complex (IDA)
  • GO:0000123 histone acetyltransferase complex (IDA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (IDA)
  • GO:0005634 nucleus (IBA)
Molecular function
  • GO:0036408 histone H3K14 acetyltransferase activity (IDA)
  • GO:0140002 histone H3K4me3 reader activity (IEA)
  • GO:0140002 histone H3K4me3 reader activity (IDA)
  • GO:0043997 histone H4K12 acetyltransferase activity (IDA)
  • GO:0046972 histone H4K16 acetyltransferase activity (IDA)
  • GO:0043995 histone H4K5 acetyltransferase activity (IDA)
  • GO:0043996 histone H4K8 acetyltransferase activity (IDA)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 17 more

Representative

Representative transcript
ENST00000619641
Representative protein
ENSP00000480978.1
Representative type
GENCODE_Primary
Candidate count
8

GENCODE Release 50 annotation GTF · transcript.tag=GENCODE_Primary; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00001067916 ING4-244 nonsense_mediated_decay not available ENSP00000737722.1 12:6,650,282 - 6,663,121 -
ENST00001067915 ING4-243 nonsense_mediated_decay not available ENSP00000737721.1 12:6,650,297 - 6,663,151 -
ENST00001005118 ING4-227 nonsense_mediated_decay not available ENSP00000674935.1 12:6,650,299 - 6,663,119 -
ENST00000396807 ING4-202 protein_coding not available ENSP00000380024.4 12:6,650,300 - 6,663,180 -
ENST00000446105 ING4-207 protein_coding not available ENSP00000415903.2 12:6,650,300 - 6,663,180 -
ENST00000906757 ING4-219 protein_coding not available ENSP00000576816.1 12:6,650,300 - 6,663,180 -
ENST00000906758 ING4-220 protein_coding not available ENSP00000576817.1 12:6,650,300 - 6,663,180 -
ENST00000906759 ING4-221 protein_coding not available ENSP00000576818.1 12:6,650,300 - 6,663,180 -
ENST00000906760 ING4-222 protein_coding not available ENSP00000576819.1 12:6,650,300 - 6,663,180 -
ENST00000906761 ING4-223 protein_coding not available ENSP00000576820.1 12:6,650,300 - 6,663,180 -
ENST00000906762 ING4-224 protein_coding not available ENSP00000576821.1 12:6,650,300 - 6,663,180 -
ENST00000906763 ING4-225 protein_coding not available ENSP00000576822.1 12:6,650,300 - 6,663,180 -
ENST00000906764 ING4-226 protein_coding not available ENSP00000576823.1 12:6,650,300 - 6,663,180 -
ENST00001140008 ING4-254 protein_coding not available ENSP00000808058.1 12:6,650,300 - 6,663,180 -
ENST00000341550 ING4-201 protein_coding not available ENSP00000343396.4 12:6,650,301 - 6,663,119 -
ENST00001005119 ING4-228 nonsense_mediated_decay not available ENSP00000674936.1 12:6,650,301 - 6,663,119 -
ENST00000619641 ING4-218 protein_coding not available ENSP00000480978.1 12:6,650,539 - 6,663,180 -
ENST00001067917 ING4-245 nonsense_mediated_decay not available ENSP00000737723.1 12:6,650,588 - 6,663,147 -
ENST00001067920 ING4-246 nonsense_mediated_decay not available ENSP00000737726.1 12:6,650,588 - 6,663,126 -
ENST00001027447 ING4-238 nonsense_mediated_decay not available ENSP00000697264.1 12:6,650,589 - 6,663,119 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.