Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

USP22

USP22

protein_coding 17 20,999,593 - 21,043,760 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000124422
Gene type
protein_coding
Chromosome
17
Coordinates
20,999,593 - 21,043,760
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

23326 CCDS42285 ENST00000261497.9 KIAA1063 NM_015276 NM_015276.2 Q9UPT9 USP3L ubiquitin specific peptidase 3-like ubiquitin specific protease 22

Summary

GENCODE gene_type=protein_coding; HGNC symbol=USP22; HGNC name=ubiquitin specific peptidase 22; alias_count=10; RefSeq=NM_015276; UniProt=Q9UPT9; MANE Select=ENST00000261497.9,NM_015276.2

Source: GENCODE + HGNC complete set

23326 • protein-coding

Alliance of Genome Resources Enables deubiquitinase activity; enzyme binding activity; and transcription coactivator activity. Contributes to histone H4 acetyltransferase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; protein deubiquitination; and regulation of gene expression. Part of SAGA complex. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q9UPT9 • reviewed

Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator (PubMed:18206972, PubMed:18206973, PubMed:18469533). Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner (PubMed:27030811). Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization (PubMed:22542455). Plays multiple roles in immunity and inflammation. Participates in antiviral response by deubiquitinating the importin KPNA2, leading to IRF3 nuclear translocation and subsequent type I interferon production (PubMed:32130408). Acts as a central regulator of type III IFN signaling by negatively regulating STING1 activation and ubiquitination (PubMed:35933402). Inhibits NLRP3 inflammasome activation by promoting NLRP3 degradation through ATG5-dependent autophagy (By similarity). Deubiquitinates CD274 to induce its stabilization and thereby participates in maintenance of immune tolerance to self (PubMed:31399419). Controls necroptotic cell death by regulating RIPK3 phosphorylation and ubiquitination (PubMed:33369872). During bacterial infection, promotes pro-inflammatory response by targeting TRAF6 and removing its 'Lys-48'-linked polyubiquitination (By similarity)

Ubiquitin carboxyl-terminal hydrolase 22 · Nucleus; Cytoplasm · EC 3.4.19.12

Q9UPT9 • reviewed

Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator (PubMed:18206972, PubMed:18206973, PubMed:18469533). Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner (PubMed:27030811). Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization (PubMed:22542455). Plays multiple roles in immunity and inflammation. Participates in antiviral response by deubiquitinating the importin KPNA2, leading to IRF3 nuclear translocation and subsequent type I interferon production (PubMed:32130408). Acts as a central regulator of type III IFN signaling by negatively regulating STING1 activation and ubiquitination (PubMed:35933402). Inhibits NLRP3 inflammasome activation by promoting NLRP3 degradation through ATG5-dependent autophagy (By similarity). Deubiquitinates CD274 to induce its stabilization and thereby participates in maintenance of immune tolerance to self (PubMed:31399419). Controls necroptotic cell death by regulating RIPK3 phosphorylation and ubiquitination (PubMed:33369872). During bacterial infection, promotes pro-inflammatory response by targeting TRAF6 and removing its 'Lys-48'-linked polyubiquitination (By similarity)

Ubiquitin carboxyl-terminal hydrolase 22 · Nucleus; Cytoplasm · EC 3.4.19.12

GO annotations

Biological process
  • GO:0000086 G2/M transition of mitotic cell cycle (IDA)
  • GO:0006338 chromatin remodeling (IEA)
  • GO:0006338 chromatin remodeling (IEA)
  • GO:0006338 chromatin remodeling (IEA)
  • GO:0009792 embryo development ending in birth or egg hatching (NAS)
  • GO:0045893 positive regulation of DNA-templated transcription (NAS)
  • GO:0045893 positive regulation of DNA-templated transcription (IMP)
  • GO:0045931 positive regulation of mitotic cell cycle (IMP)
  • GO:0032481 positive regulation of type I interferon production (IDA)
  • GO:0016579 protein deubiquitination (IEA)

+ 5 more

Cellular component
  • GO:0000124 SAGA complex (IDA)
  • GO:0000124 SAGA complex (IDA)
  • GO:0000124 SAGA complex (NAS)
  • GO:0000124 SAGA complex (IDA)
  • GO:0005737 cytoplasm (IC)
  • GO:0005737 cytoplasm (ISS)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005634 nucleus (IC)
  • GO:0005634 nucleus (IEA)

+ 2 more

Molecular function
  • GO:0004843 cysteine-type deubiquitinase activity (IMP)
  • GO:0004843 cysteine-type deubiquitinase activity (IEA)
  • GO:0004843 cysteine-type deubiquitinase activity (IEA)
  • GO:0004843 cysteine-type deubiquitinase activity (IEA)
  • GO:0004843 cysteine-type deubiquitinase activity (IEA)
  • GO:0004843 cysteine-type deubiquitinase activity (IDA)
  • GO:0004843 cysteine-type deubiquitinase activity (EXP)
  • GO:0004843 cysteine-type deubiquitinase activity (EXP)
  • GO:0004843 cysteine-type deubiquitinase activity (IDA)
  • GO:0004843 cysteine-type deubiquitinase activity (EXP)

+ 23 more

Representative

Representative transcript
ENST00000261497
Representative protein
ENSP00000261497.4
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00001000661 USP22-218 nonsense_mediated_decay not available ENSP00000670478.1 17:20,999,593 - 21,043,013 -
ENST00000261497 USP22-201 protein_coding not available ENSP00000261497.4 17:20,999,596 - 21,043,011 -
ENST00001086453 USP22-220 nonsense_mediated_decay not available ENSP00000756259.1 17:20,999,596 - 21,043,106 -
ENST00001086454 USP22-221 nonsense_mediated_decay not available ENSP00000756260.1 17:20,999,596 - 21,043,047 -
ENST00001086455 USP22-222 nonsense_mediated_decay not available ENSP00000756261.1 17:20,999,596 - 21,043,046 -
ENST00001136623 USP22-225 protein_coding not available ENSP00000803148.1 17:20,999,596 - 21,043,070 -
ENST00000537526 USP22-206 protein_coding not available ENSP00000440950.2 17:20,999,597 - 21,043,760 -
ENST00001086457 USP22-223 nonsense_mediated_decay not available ENSP00000756263.1 17:20,999,597 - 21,043,042 -
ENST00001117256 USP22-224 nonsense_mediated_decay not available ENSP00000787061.1 17:20,999,597 - 21,043,071 -
ENST00000952978 USP22-217 protein_coding not available ENSP00000623037.1 17:20,999,598 - 21,043,070 -
ENST00000929028 USP22-213 protein_coding not available ENSP00000599087.1 17:20,999,599 - 21,043,070 -
ENST00000929029 USP22-214 protein_coding not available ENSP00000599088.1 17:20,999,599 - 21,043,070 -
ENST00000884362 USP22-212 protein_coding not available ENSP00000554421.1 17:20,999,739 - 21,043,070 -
ENST00000929030 USP22-215 protein_coding not available ENSP00000599089.1 17:20,999,739 - 21,043,070 -
ENST00001000665 USP22-219 protein_coding not available ENSP00000670482.1 17:20,999,757 - 21,043,070 -
ENST00000929031 USP22-216 protein_coding not available ENSP00000599090.1 17:20,999,767 - 21,043,070 -
ENST00000455117 USP22-202 protein_coding_CDS_not_defined not available not available 17:21,002,375 - 21,043,375 -
ENST00000579645 USP22-209 nonsense_mediated_decay not available ENSP00000464398.1 17:21,002,972 - 21,043,760 -
ENST00000463692 USP22-203 retained_intron not available not available 17:21,004,220 - 21,005,150 -
ENST00000478443 USP22-205 retained_intron not available not available 17:21,006,508 - 21,011,614 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.