Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

SESN2

SESN2

protein_coding 1 28,259,473 - 28,282,491 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000130766
Gene type
protein_coding
Chromosome
1
Coordinates
28,259,473 - 28,282,491
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

83667 CCDS321 DKFZp761M0212 ENST00000253063.4 HI95 NM_031459 NM_031459.5 P58004 SES2 SEST2

Summary

GENCODE gene_type=protein_coding; HGNC symbol=SESN2; HGNC name=sestrin 2; alias_count=10; RefSeq=NM_031459; UniProt=P58004; MANE Select=ENST00000253063.4,NM_031459.5

Source: GENCODE + HGNC complete set

83667 • protein-coding

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

P58004 • reviewed

Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100, PubMed:35831510, PubMed:36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821)

Sestrin-2 · Cytoplasm

GO annotations

Biological process
  • GO:0030330 DNA damage response, signal transduction by p53 class mediator (IEA)
  • GO:0030330 DNA damage response, signal transduction by p53 class mediator (IMP)
  • GO:0038203 TORC2 signaling (IMP)
  • GO:0032147 activation of protein kinase activity (IDA)
  • GO:0032147 activation of protein kinase activity (IMP)
  • GO:0098869 cellular oxidant detoxification (IDA)
  • GO:0098869 cellular oxidant detoxification (IMP)
  • GO:0098869 cellular oxidant detoxification (IDA)
  • GO:0071233 cellular response to L-leucine (IDA)
  • GO:0071233 cellular response to L-leucine (IMP)

+ 38 more

Cellular component
  • GO:1990316 Atg1/ULK1 kinase complex (IPI)
  • GO:0061700 GATOR2 complex (IDA)
  • GO:0031932 TORC2 complex (ISS)
  • GO:0031932 TORC2 complex (IEA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 9 more

Molecular function
  • GO:0005092 GDP-dissociation inhibitor activity (IEA)
  • GO:0070728 L-leucine binding (IDA)
  • GO:0070728 L-leucine binding (IDA)
  • GO:0070728 L-leucine binding (IDA)
  • GO:0070728 L-leucine binding (IDA)
  • GO:0070728 L-leucine binding (IBA)
  • GO:0042731 PH domain binding (IEA)
  • GO:0042731 PH domain binding (IPI)
  • GO:0016684 oxidoreductase activity, acting on peroxide as acceptor (IBA)
  • GO:0004601 peroxidase activity (IDA)

+ 32 more

Representative

Representative transcript
ENST00000253063
Representative protein
ENSP00000253063.3
Representative type
CCDS
Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000862801 SESN2-202 protein_coding not available ENSP00000532860.1 1:28,259,473 - 28,282,491 +
ENST00000862802 SESN2-203 protein_coding not available ENSP00000532861.1 1:28,259,473 - 28,282,491 +
ENST00000862803 SESN2-204 protein_coding not available ENSP00000532862.1 1:28,259,473 - 28,282,491 +
ENST00000862804 SESN2-205 protein_coding not available ENSP00000532863.1 1:28,259,473 - 28,282,491 +
ENST00000862805 SESN2-206 protein_coding not available ENSP00000532864.1 1:28,259,473 - 28,282,491 +
ENST00000862806 SESN2-207 protein_coding not available ENSP00000532865.1 1:28,259,473 - 28,282,491 +
ENST00000862807 SESN2-208 protein_coding not available ENSP00000532866.1 1:28,259,473 - 28,282,491 +
ENST00000929850 SESN2-209 protein_coding not available ENSP00000599909.1 1:28,259,473 - 28,282,491 +
ENST00000929851 SESN2-210 protein_coding not available ENSP00000599910.1 1:28,259,473 - 28,282,491 +
ENST00000929852 SESN2-211 protein_coding not available ENSP00000599911.1 1:28,259,473 - 28,282,491 +
ENST00000929853 SESN2-212 protein_coding not available ENSP00000599912.1 1:28,259,473 - 28,282,491 +
ENST00000929854 SESN2-213 protein_coding not available ENSP00000599913.1 1:28,259,473 - 28,282,491 +
ENST00000960546 SESN2-214 protein_coding not available ENSP00000630605.1 1:28,259,473 - 28,282,491 +
ENST00000960547 SESN2-215 protein_coding not available ENSP00000630606.1 1:28,259,473 - 28,282,491 +
ENST00001128072 SESN2-221 protein_coding not available ENSP00000797877.1 1:28,259,473 - 28,282,491 +
ENST00001145886 SESN2-222 protein_coding not available ENSP00000802653.1 1:28,259,473 - 28,282,491 +
ENST00000973796 SESN2-216 nonsense_mediated_decay not available ENSP00000643613.1 1:28,259,482 - 28,282,488 +
ENST00001069774 SESN2-218 nonsense_mediated_decay not available ENSP00000739580.1 1:28,259,504 - 28,282,491 +
ENST00001069775 SESN2-219 nonsense_mediated_decay not available ENSP00000739581.1 1:28,259,504 - 28,282,490 +
ENST00000973797 SESN2-217 nonsense_mediated_decay not available ENSP00000643614.1 1:28,259,511 - 28,282,490 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.