Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

XRCC3

XRCC3

protein_coding 14 103,697,569 - 103,715,504 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000126215
Gene type
protein_coding
Chromosome
14
Coordinates
103,697,569 - 103,715,504
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

7517 CCDS9984 DNA repair protein XRCC3 ENST00000555055.6 NM_005432 NM_005432.4 O43542 RAD51-like X-ray repair complementing defective repair in Chinese hamster cells 3

Summary

GENCODE gene_type=protein_coding; HGNC symbol=XRCC3; HGNC name=X-ray repair cross complementing 3; alias_count=9; RefSeq=NM_005432; UniProt=O43542; MANE Select=ENST00000555055.6,NM_005432.4

Source: GENCODE + HGNC complete set

7517 • protein-coding

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

O43542 • reviewed

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C

DNA repair protein XRCC3 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region; Mitochondrion

O43542 • reviewed

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C

DNA repair protein XRCC3 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region; Mitochondrion

O43542 • reviewed

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C

DNA repair protein XRCC3 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region; Mitochondrion

O43542 • reviewed

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C

DNA repair protein XRCC3 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region; Mitochondrion

GO annotations

Biological process
  • GO:0006974 DNA damage response (TAS)
  • GO:0006310 DNA recombination (TAS)
  • GO:0006281 DNA repair (IEA)
  • GO:0006281 DNA repair (IGI)
  • GO:0006281 DNA repair (TAS)
  • GO:0000724 double-strand break repair via homologous recombination (IMP)
  • GO:0000724 double-strand break repair via homologous recombination (NAS)
  • GO:0045003 double-strand break repair via synthesis-dependent strand annealing (IBA)
  • GO:0036297 interstrand cross-link repair (IMP)
  • GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint (IMP)

+ 11 more

Cellular component
  • GO:0033065 Rad51C-XRCC3 complex (IDA)
  • GO:0033065 Rad51C-XRCC3 complex (IPI)
  • GO:0033065 Rad51C-XRCC3 complex (IBA)
  • GO:0000781 chromosome, telomeric region (IC)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005739 mitochondrion (IEA)
  • GO:0005739 mitochondrion (IDA)
  • GO:0043596 nuclear replication fork (IDA)
  • GO:0005654 nucleoplasm (IDA)

+ 18 more

Molecular function
  • GO:0005524 ATP binding (IEA)
  • GO:0140664 ATP-dependent DNA damage sensor activity (IEA)
  • GO:0003677 DNA binding (IEA)
  • GO:0008821 crossover junction DNA endonuclease activity (IMP)
  • GO:0008821 crossover junction DNA endonuclease activity (IMP)
  • GO:0000400 four-way junction DNA binding (IDA)
  • GO:0000400 four-way junction DNA binding (IBA)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 10 more

Representative

Representative transcript
ENST00000352127
Representative protein
ENSP00000343392.7
Representative type
CCDS
Candidate count
57

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000352127 XRCC3-201 protein_coding not available ENSP00000343392.7 14:103,697,569 - 103,715,504 -
ENST00000553264 XRCC3-202 protein_coding not available ENSP00000451974.1 14:103,697,569 - 103,712,104 -
ENST00000554913 XRCC3-209 protein_coding not available ENSP00000451362.1 14:103,697,569 - 103,715,504 -
ENST00000554974 XRCC3-210 protein_coding not available ENSP00000451361.1 14:103,697,569 - 103,715,459 -
ENST00000881941 XRCC3-219 protein_coding not available ENSP00000552000.1 14:103,697,569 - 103,715,504 -
ENST00000881942 XRCC3-220 protein_coding not available ENSP00000552001.1 14:103,697,569 - 103,715,504 -
ENST00000881943 XRCC3-221 protein_coding not available ENSP00000552002.1 14:103,697,569 - 103,715,504 -
ENST00000881944 XRCC3-222 protein_coding not available ENSP00000552003.1 14:103,697,569 - 103,715,504 -
ENST00000881945 XRCC3-223 protein_coding not available ENSP00000552004.1 14:103,697,569 - 103,715,504 -
ENST00000881946 XRCC3-224 protein_coding not available ENSP00000552005.1 14:103,697,569 - 103,715,504 -
ENST00000881947 XRCC3-225 protein_coding not available ENSP00000552006.1 14:103,697,569 - 103,715,451 -
ENST00000881948 XRCC3-226 protein_coding not available ENSP00000552007.1 14:103,697,569 - 103,715,451 -
ENST00000881949 XRCC3-227 protein_coding not available ENSP00000552008.1 14:103,697,569 - 103,715,449 -
ENST00000881950 XRCC3-228 protein_coding not available ENSP00000552009.1 14:103,697,569 - 103,715,449 -
ENST00000881951 XRCC3-229 protein_coding not available ENSP00000552010.1 14:103,697,569 - 103,715,421 -
ENST00000881952 XRCC3-230 protein_coding not available ENSP00000552011.1 14:103,697,569 - 103,715,449 -
ENST00000920655 XRCC3-231 protein_coding not available ENSP00000590714.1 14:103,697,569 - 103,715,504 -
ENST00000920656 XRCC3-232 protein_coding not available ENSP00000590715.1 14:103,697,569 - 103,715,451 -
ENST00000920657 XRCC3-233 protein_coding not available ENSP00000590716.1 14:103,697,569 - 103,715,504 -
ENST00000920658 XRCC3-234 protein_coding not available ENSP00000590717.1 14:103,697,569 - 103,715,504 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.