Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

XRCC2

protein_coding 7 152,644,771 - 152,676,201 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000196584

Gene type
protein_coding

Chromosome
7

Coordinates
152,644,771 - 152,676,201

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

7516 CCDS5933 DNA repair protein XRCC2 ENST00000359321.2 FANCU NM_005431 NM_005431.2 O43543 RAD51-like X-ray repair complementing defective repair in Chinese hamster cells 2

Summary

GENCODE gene_type=protein_coding; HGNC symbol=XRCC2; HGNC name=X-ray repair cross complementing 2; alias_count=10; RefSeq=NM_005431; UniProt=O43543; MANE Select=ENST00000359321.2,NM_005431.2

Source: GENCODE + HGNC complete set

7516 • protein-coding

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

O43543 • reviewed

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

DNA repair protein XRCC2 · Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

GO annotations

Biological process

GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (IGI)
GO:0006281 DNA repair (TAS)
GO:0042148 DNA strand invasion (IDA)
GO:0042148 DNA strand invasion (IBA)
GO:0007098 centrosome cycle (IMP)
GO:0000724 double-strand break repair via homologous recombination (IEA)
GO:0000724 double-strand break repair via homologous recombination (IMP)
GO:0000724 double-strand break repair via homologous recombination (IBA)
GO:0051321 meiotic cell cycle (TAS)

+ 2 more

Cellular component

GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex (IEA)
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex (IDA)
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex (IPI)
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex (IBA)
GO:0005813 centrosome (IEA)
GO:0005813 centrosome (IDA)
GO:0005813 centrosome (IBA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)

+ 19 more

Molecular function

GO:0005524 ATP binding (IEA)
GO:0140664 ATP-dependent DNA damage sensor activity (IEA)
GO:0003677 DNA binding (IEA)
GO:0000400 four-way junction DNA binding (IDA)
GO:0000400 four-way junction DNA binding (IBA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 14 more

Representative

Representative transcript
ENST00000698506

Representative protein
ENSP00000513758.1

Representative type
GENCODE_Primary

Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=GENCODE_Primary; transcript_support_level=NA

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00001063163	XRCC2-206	nonsense_mediated_decay	not available	ENSP00000732969.1	7:152,644,771 - 152,676,167 -
ENST00001063164	XRCC2-207	protein_coding	not available	ENSP00000732970.1	7:152,644,771 - 152,676,193 -
ENST00000359321	XRCC2-201	protein_coding	not available	ENSP00000352271.1	7:152,644,776 - 152,676,141 -
ENST00001139057	XRCC2-213	protein_coding	not available	ENSP00000808734.1	7:152,644,776 - 152,676,193 -
ENST00000495707	XRCC2-202	protein_coding_CDS_not_defined	not available	not available	7:152,644,779 - 152,664,004 -
ENST00001063165	XRCC2-208	nonsense_mediated_decay	not available	ENSP00000732971.1	7:152,646,475 - 152,676,147 -
ENST00000698506	XRCC2-203	protein_coding	not available	ENSP00000513758.1	7:152,646,624 - 152,676,193 -
ENST00001063166	XRCC2-209	protein_coding	not available	ENSP00000732972.1	7:152,646,914 - 152,676,193 -
ENST00001013524	XRCC2-205	nonsense_mediated_decay	not available	ENSP00000683341.1	7:152,647,609 - 152,676,201 -
ENST00001096799	XRCC2-211	protein_coding	not available	ENSP00000766605.1	7:152,647,984 - 152,676,193 -
ENST00001063167	XRCC2-210	protein_coding	not available	ENSP00000732973.1	7:152,648,039 - 152,676,193 -
ENST00001096800	XRCC2-212	protein_coding	not available	ENSP00000766606.1	7:152,656,764 - 152,676,193 -
ENST00000698507	XRCC2-204	retained_intron	not available	not available	7:152,659,137 - 152,676,147 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.