Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

XRCC1

protein_coding 19 43,543,306 - 43,580,473 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000073050

Gene type
protein_coding

Chromosome
19

Coordinates
43,543,306 - 43,580,473

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

7515 CCDS12624 DNA repair protein XRCC1 ENST00000262887.10 NM_006297 NM_006297.3 P18887 RCC X-ray repair complementing defective repair in Chinese hamster cells 1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=XRCC1; HGNC name=X-ray repair cross complementing 1; alias_count=9; RefSeq=NM_006297; UniProt=P18887; MANE Select=ENST00000262887.10,NM_006297.3

Source: GENCODE + HGNC complete set

7515 • protein-coding

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

P18887 • reviewed

Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483)

DNA repair protein XRCC1 · Nucleus; Chromosome

GO annotations

Biological process

GO:0006284 base-excision repair (IEA)
GO:0006284 base-excision repair (IDA)
GO:0006284 base-excision repair (IDA)
GO:0006284 base-excision repair (IDA)
GO:0006284 base-excision repair (IBA)
GO:0006302 double-strand break repair (IDA)
GO:0006303 double-strand break repair via nonhomologous end joining (IEA)
GO:0006303 double-strand break repair via nonhomologous end joining (IEA)
GO:1905765 negative regulation of protection from non-homologous end joining at telomere (IEA)
GO:0010836 negative regulation of protein ADP-ribosylation (IDA)

+ 8 more

Cellular component

GO:0070421 DNA ligase III-XRCC1 complex (NAS)
GO:0070522 ERCC4-ERCC1 complex (IEA)
GO:0000785 chromatin (IDA)
GO:0005694 chromosome (IEA)
GO:0005694 chromosome (EXP)
GO:0000781 chromosome, telomeric region (IEA)
GO:0005730 nucleolus (IDA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (IEA)
GO:0005654 nucleoplasm (TAS)

+ 22 more

Molecular function

GO:1990599 3' overhang single-stranded DNA endonuclease activity (IEA)
GO:0160002 ADP-D-ribose modification-dependent protein binding (IDA)
GO:0003684 damaged DNA binding (IEA)
GO:0019899 enzyme binding (IPI)
GO:0019899 enzyme binding (IPI)
GO:0032356 oxidized DNA binding (IMP)
GO:0072572 poly-ADP-D-ribose binding (IDA)
GO:0072572 poly-ADP-D-ribose binding (IDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 33 more

Representative

Representative transcript
ENST00000262887

Representative protein
ENSP00000262887.5

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000543982	XRCC1-202	protein_coding	not available	ENSP00000443671.1	19:43,543,306 - 43,575,648 -
ENST00000865399	XRCC1-210	protein_coding	not available	ENSP00000535458.1	19:43,543,306 - 43,575,648 -
ENST00000865400	XRCC1-211	protein_coding	not available	ENSP00000535459.1	19:43,543,306 - 43,575,648 -
ENST00000865401	XRCC1-212	protein_coding	not available	ENSP00000535460.1	19:43,543,306 - 43,575,648 -
ENST00000865402	XRCC1-213	protein_coding	not available	ENSP00000535461.1	19:43,543,306 - 43,575,648 -
ENST00000865403	XRCC1-214	protein_coding	not available	ENSP00000535462.1	19:43,543,306 - 43,575,648 -
ENST00000865404	XRCC1-215	protein_coding	not available	ENSP00000535463.1	19:43,543,306 - 43,575,648 -
ENST00000865405	XRCC1-216	protein_coding	not available	ENSP00000535464.1	19:43,543,306 - 43,575,648 -
ENST00000934412	XRCC1-217	protein_coding	not available	ENSP00000604471.1	19:43,543,306 - 43,575,648 -
ENST00000934413	XRCC1-218	protein_coding	not available	ENSP00000604472.1	19:43,543,306 - 43,575,648 -
ENST00000953254	XRCC1-219	protein_coding	not available	ENSP00000623313.1	19:43,543,306 - 43,575,648 -
ENST00000953255	XRCC1-220	protein_coding	not available	ENSP00000623314.1	19:43,543,306 - 43,575,648 -
ENST00000953256	XRCC1-221	protein_coding	not available	ENSP00000623315.1	19:43,543,306 - 43,575,648 -
ENST00000953257	XRCC1-222	protein_coding	not available	ENSP00000623316.1	19:43,543,306 - 43,575,648 -
ENST00000953258	XRCC1-223	protein_coding	not available	ENSP00000623317.1	19:43,543,306 - 43,575,648 -
ENST00000993373	XRCC1-224	nonsense_mediated_decay	not available	ENSP00000663190.1	19:43,543,306 - 43,575,621 -
ENST00001142627	XRCC1-226	protein_coding	not available	ENSP00000803377.1	19:43,543,306 - 43,575,648 -
ENST00001081064	XRCC1-225	nonsense_mediated_decay	not available	ENSP00000750870.1	19:43,543,309 - 43,575,527 -
ENST00000262887	XRCC1-201	protein_coding	not available	ENSP00000262887.5	19:43,543,311 - 43,575,527 -
ENST00000597811	XRCC1-206	nonsense_mediated_decay	not available	ENSP00000470391.1	19:43,551,571 - 43,560,949 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.