Human_Genes_Functions
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Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

WRAP53

WRAP53

protein_coding 17 7,686,071 - 7,703,505 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000141499
Gene type
protein_coding
Chromosome
17
Coordinates
7,686,071 - 7,703,505
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

55135 CCDS11119 ENST00000396463.7 FLJ10385 NM_001143992.2 NM_018081 Q9BUR4 TCAB1 WD repeat containing, antisense to TP53 WD repeat domain 79 WD-encoding RNA antisense to p53 WDR79 telomerase cajal body protein 1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=WRAP53; HGNC name=WD repeat containing antisense to TP53; alias_count=14; RefSeq=NM_018081; UniProt=Q9BUR4; MANE Select=ENST00000396463.7,NM_001143992.2

Source: GENCODE + HGNC complete set

55135 • protein-coding

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

NCBI Gene

UniProt

Q9BUR4 • reviewed

RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493)

Telomerase Cajal body protein 1 · Nucleus, Cajal body; Chromosome, telomere; Chromosome

Q9BUR4 • reviewed

RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493)

Telomerase Cajal body protein 1 · Nucleus, Cajal body; Chromosome, telomere; Chromosome

Q9BUR4 • reviewed

RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493)

Telomerase Cajal body protein 1 · Nucleus, Cajal body; Chromosome, telomere; Chromosome

Q9BUR4 • reviewed

RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493)

Telomerase Cajal body protein 1 · Nucleus, Cajal body; Chromosome, telomere; Chromosome

GO annotations

Biological process
  • GO:0030576 Cajal body organization (IMP)
  • GO:0030576 Cajal body organization (IBA)
  • GO:0034337 RNA folding (IDA)
  • GO:0045739 positive regulation of DNA repair (IDA)
  • GO:2000781 positive regulation of double-strand break repair (IDA)
  • GO:1905168 positive regulation of double-strand break repair via homologous recombination (IDA)
  • GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining (IDA)
  • GO:1904851 positive regulation of establishment of protein localization to telomere (IMP)
  • GO:0032212 positive regulation of telomere maintenance via telomerase (IDA)
  • GO:1904867 protein localization to Cajal body (IDA)

+ 11 more

Cellular component
  • GO:0015030 Cajal body (IEA)
  • GO:0015030 Cajal body (IDA)
  • GO:0015030 Cajal body (IDA)
  • GO:0015030 Cajal body (IDA)
  • GO:0015030 Cajal body (IDA)
  • GO:0015030 Cajal body (IMP)
  • GO:0015030 Cajal body (IDA)
  • GO:0015030 Cajal body (IBA)
  • GO:0005694 chromosome (IEA)
  • GO:0005694 chromosome (EXP)

+ 20 more

Molecular function
  • GO:0003723 RNA binding (IDA)
  • GO:0003723 RNA binding (IPI)
  • GO:0003723 RNA binding (IBA)
  • GO:0140691 RNA folding chaperone (IEA)
  • GO:0140691 RNA folding chaperone (IDA)
  • GO:0140691 RNA folding chaperone (IDA)
  • GO:0042393 histone binding (IPI)
  • GO:0042393 histone binding (IPI)
  • GO:0042802 identical protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 26 more

Representative

Representative transcript
ENST00000316024
Representative protein
ENSP00000324203.5
Representative type
CCDS
Candidate count
9

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000431639 WRAP53-203 protein_coding not available ENSP00000397219.2 17:7,686,071 - 7,703,505 +
ENST00000316024 WRAP53-201 protein_coding not available ENSP00000324203.5 17:7,686,301 - 7,703,505 +
ENST00000534050 WRAP53-210 protein_coding not available ENSP00000434999.1 17:7,686,301 - 7,703,505 +
ENST00000932533 WRAP53-219 protein_coding not available ENSP00000602592.1 17:7,686,301 - 7,703,505 +
ENST00001025336 WRAP53-226 protein_coding not available ENSP00000695153.1 17:7,686,301 - 7,703,505 +
ENST00001025335 WRAP53-225 nonsense_mediated_decay not available ENSP00000695152.1 17:7,686,677 - 7,703,501 +
ENST00000457584 WRAP53-204 protein_coding not available ENSP00000411061.2 17:7,687,440 - 7,703,505 +
ENST00000498311 WRAP53-209 nonsense_mediated_decay not available ENSP00000432991.1 17:7,687,600 - 7,703,501 +
ENST00000698742 WRAP53-211 protein_coding not available ENSP00000513904.1 17:7,687,913 - 7,703,505 +
ENST00000698746 WRAP53-215 protein_coding not available ENSP00000513908.1 17:7,687,913 - 7,703,505 +
ENST00000868853 WRAP53-217 protein_coding not available ENSP00000538912.1 17:7,687,913 - 7,703,505 +
ENST00000868854 WRAP53-218 protein_coding not available ENSP00000538913.1 17:7,687,913 - 7,703,505 +
ENST00000932534 WRAP53-220 protein_coding not available ENSP00000602593.1 17:7,687,913 - 7,703,505 +
ENST00000932535 WRAP53-221 protein_coding not available ENSP00000602594.1 17:7,687,913 - 7,703,505 +
ENST00000964568 WRAP53-222 protein_coding not available ENSP00000634627.1 17:7,687,913 - 7,703,505 +
ENST00001102250 WRAP53-237 protein_coding not available ENSP00000772056.1 17:7,687,913 - 7,695,942 +
ENST00001143473 WRAP53-239 protein_coding not available ENSP00000811902.1 17:7,687,913 - 7,703,505 +
ENST00000988414 WRAP53-223 nonsense_mediated_decay not available ENSP00000658231.1 17:7,688,311 - 7,703,502 +
ENST00001076119 WRAP53-229 nonsense_mediated_decay not available ENSP00000745925.1 17:7,688,359 - 7,703,501 +
ENST00001076120 WRAP53-230 nonsense_mediated_decay not available ENSP00000745926.1 17:7,688,361 - 7,703,502 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.