Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

UBXN2A

protein_coding 2 23,926,788 - 24,004,909 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000173960

Gene type
protein_coding

Chromosome
2

Coordinates
23,926,788 - 24,004,909

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

165324 CCDS1704 ENST00000309033.5 NM_181713 NM_181713.4 P68543 UBX domain containing 4 UBXD4

Summary

GENCODE gene_type=protein_coding; HGNC symbol=UBXN2A; HGNC name=UBX domain protein 2A; alias_count=8; RefSeq=NM_181713; UniProt=P68543; MANE Select=ENST00000309033.5,NM_181713.4

Source: GENCODE + HGNC complete set

165324 • protein-coding

Alliance of Genome Resources Predicted to enable ubiquitin binding activity. Involved in negative regulation of ERAD pathway and positive regulation of protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

P68543 • reviewed

Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (PubMed:24625977, PubMed:26634371). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (PubMed:37037900)

UBX domain-containing protein 2A · Golgi apparatus; Endoplasmic reticulum; Perikaryon; Cell projection, dendrite; Nucleus; Cytoplasm

P68543 • reviewed

UBX domain-containing protein 2A · Golgi apparatus; Endoplasmic reticulum; Perikaryon; Cell projection, dendrite; Nucleus; Cytoplasm

GO annotations

Biological process

GO:0007030 Golgi organization (IBA)
GO:0000045 autophagosome assembly (IBA)
GO:0061025 membrane fusion (IBA)
GO:1904293 negative regulation of ERAD pathway (IMP)
GO:0045861 negative regulation of proteolysis (IMP)
GO:0031468 nuclear membrane reassembly (IBA)
GO:0045732 positive regulation of protein catabolic process (IMP)
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

Cellular component

GO:1904949 ATPase complex (IPI)
GO:0005794 Golgi apparatus (ISS)
GO:0005794 Golgi apparatus (ISS)
GO:0005794 Golgi apparatus (IEA)
GO:0005794 Golgi apparatus (IEA)
GO:0005801 cis-Golgi network (IEA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005829 cytosol (IEA)
GO:0005829 cytosol (IBA)

+ 10 more

Molecular function

GO:0033130 acetylcholine receptor binding (IEA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 8 more

Representative

Representative transcript
ENST00000309033

Representative protein
ENSP00000312107.4

Representative type
CCDS

Candidate count
21

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000404924	UBXN2A-202	protein_coding	not available	ENSP00000385525.1	2:23,926,788 - 24,004,909 +
ENST00000906993	UBXN2A-205	protein_coding	not available	ENSP00000577052.1	2:23,926,788 - 24,004,909 +
ENST00000906994	UBXN2A-206	protein_coding	not available	ENSP00000577053.1	2:23,926,788 - 24,004,909 +
ENST00000906996	UBXN2A-208	protein_coding	not available	ENSP00000577055.1	2:23,926,788 - 24,004,909 +
ENST00000906995	UBXN2A-207	protein_coding	not available	ENSP00000577054.1	2:23,927,252 - 24,004,909 +
ENST00000951750	UBXN2A-224	protein_coding	not available	ENSP00000621809.1	2:23,927,252 - 24,004,909 +
ENST00000951751	UBXN2A-225	protein_coding	not available	ENSP00000621810.1	2:23,927,252 - 24,004,909 +
ENST00000446425	UBXN2A-203	protein_coding_CDS_not_defined	not available	not available	2:23,927,285 - 24,000,820 +
ENST00000912493	UBXN2A-216	protein_coding	not available	ENSP00000582552.1	2:23,939,382 - 24,004,909 +
ENST00000912494	UBXN2A-217	protein_coding	not available	ENSP00000582553.1	2:23,939,467 - 24,004,909 +
ENST00000912495	UBXN2A-218	protein_coding	not available	ENSP00000582554.1	2:23,939,788 - 24,004,909 +
ENST00000912496	UBXN2A-219	protein_coding	not available	ENSP00000582555.1	2:23,939,788 - 24,004,909 +
ENST00000912497	UBXN2A-220	protein_coding	not available	ENSP00000582556.1	2:23,939,797 - 24,004,909 +
ENST00000906997	UBXN2A-209	protein_coding	not available	ENSP00000577056.1	2:23,940,431 - 24,004,909 +
ENST00000906998	UBXN2A-210	protein_coding	not available	ENSP00000577057.1	2:23,940,431 - 24,004,909 +
ENST00000906999	UBXN2A-211	protein_coding	not available	ENSP00000577058.1	2:23,940,431 - 24,004,909 +
ENST00000907000	UBXN2A-212	protein_coding	not available	ENSP00000577059.1	2:23,940,431 - 24,004,909 +
ENST00000907001	UBXN2A-213	protein_coding	not available	ENSP00000577060.1	2:23,940,431 - 24,004,909 +
ENST00000907003	UBXN2A-215	protein_coding	not available	ENSP00000577062.1	2:23,940,431 - 24,004,909 +
ENST00000912498	UBXN2A-221	protein_coding	not available	ENSP00000582557.1	2:23,940,431 - 24,004,909 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.