Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

TRIM69

TRIM69

protein_coding 15 44,728,986 - 44,767,829 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000185880
Gene type
protein_coding
Chromosome
15
Coordinates
44,728,986 - 44,767,829
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

140691 CCDS10114 CCDS32220 CCDS73719 CCDS76745 CCDS76746 ENST00000329464.9 NM_001301144 NM_182985.5 Q86WT6 RNF36 TRIMLESS Trif ring finger protein 36 tripartite motif-containing 69

Summary

GENCODE gene_type=protein_coding; HGNC symbol=TRIM69; HGNC name=tripartite motif containing 69; alias_count=15; RefSeq=NM_001301144; UniProt=Q86WT6; MANE Select=ENST00000329464.9,NM_182985.5

Source: GENCODE + HGNC complete set

140691 • protein-coding

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q86WT6 • reviewed

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411)

E3 ubiquitin-protein ligase TRIM69 · Cytoplasm; Nucleus; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · EC 2.3.2.27

Q86WT6 • reviewed

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411)

E3 ubiquitin-protein ligase TRIM69 · Cytoplasm; Nucleus; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · EC 2.3.2.27

Q86WT6 • reviewed

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411)

E3 ubiquitin-protein ligase TRIM69 · Cytoplasm; Nucleus; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · EC 2.3.2.27

Q86WT6 • reviewed

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411)

E3 ubiquitin-protein ligase TRIM69 · Cytoplasm; Nucleus; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · EC 2.3.2.27

Q86WT6 • reviewed

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411)

E3 ubiquitin-protein ligase TRIM69 · Cytoplasm; Nucleus; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · EC 2.3.2.27

GO annotations

Biological process
  • GO:0045087 innate immune response (IBA)
  • GO:0141111 positive regulation of cGAS/STING signaling pathway (IDA)
  • GO:0070534 protein K63-linked ubiquitination (IDA)
  • GO:0071539 protein localization to centrosome (IDA)
  • GO:0016567 protein ubiquitination (IEA)
Cellular component
  • GO:0005813 centrosome (IDA)
  • GO:0005813 centrosome (IEA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005737 cytoplasm (IBA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 5 more

Molecular function
  • GO:0042802 identical protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 88 more

Representative

Representative transcript
ENST00000329464
Representative protein
ENSP00000332284.3
Representative type
CCDS
Candidate count
7

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000559390 TRIM69-206 protein_coding not available ENSP00000453177.1 15:44,728,986 - 44,767,829 +
ENST00000870291 TRIM69-216 protein_coding not available ENSP00000540350.1 15:44,728,986 - 44,767,829 +
ENST00000971067 TRIM69-217 protein_coding not available ENSP00000641126.1 15:44,728,986 - 44,767,829 +
ENST00001128993 TRIM69-218 protein_coding not available ENSP00000798798.1 15:44,728,986 - 44,738,644 +
ENST00000560141 TRIM69-207 protein_coding_CDS_not_defined not available not available 15:44,729,001 - 44,734,000 +
ENST00000560554 TRIM69-209 protein_coding_CDS_not_defined not available not available 15:44,729,055 - 44,736,613 +
ENST00000559315 TRIM69-205 protein_coding_CDS_not_defined not available not available 15:44,729,073 - 44,736,562 +
ENST00000714088 TRIM69-214 nonsense_mediated_decay not available ENSP00000519379.1 15:44,729,073 - 44,767,575 +
ENST00000561237 TRIM69-212 protein_coding_CDS_not_defined not available not available 15:44,729,142 - 44,731,715 +
ENST00000329464 TRIM69-201 protein_coding not available ENSP00000332284.3 15:44,736,528 - 44,767,827 +
ENST00000338264 TRIM69-202 protein_coding not available ENSP00000342922.4 15:44,736,528 - 44,767,829 +
ENST00000561043 TRIM69-210 protein_coding not available ENSP00000453077.1 15:44,736,528 - 44,767,829 +
ENST00000714085 TRIM69-213 nonsense_mediated_decay not available ENSP00000519376.1 15:44,736,528 - 44,767,827 +
ENST00001137112 TRIM69-219 protein_coding not available ENSP00000807359.1 15:44,736,528 - 44,767,829 +
ENST00000558329 TRIM69-204 protein_coding not available ENSP00000453332.1 15:44,736,530 - 44,767,829 +
ENST00000560442 TRIM69-208 protein_coding not available ENSP00000453549.1 15:44,736,530 - 44,767,829 +
ENST00000714089 TRIM69-215 nonsense_mediated_decay not available ENSP00000519380.1 15:44,736,603 - 44,767,827 +
ENST00000558173 TRIM69-203 retained_intron not available not available 15:44,752,918 - 44,767,827 +
ENST00000561170 TRIM69-211 protein_coding not available ENSP00000452739.1 15:44,758,774 - 44,767,443 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.