Human_Genes_Functions
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Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

TRIM24

TRIM24

protein_coding 7 138,460,193 - 138,590,023 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000122779
Gene type
protein_coding
Chromosome
7
Coordinates
138,460,193 - 138,590,023
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

8805 CCDS47720 CCDS5847 ENST00000343526.9 NM_015905 NM_015905.3 O15164 RNF82 TIF1 TIF1A Tif1a hTIF1 transcriptional intermediary factor 1 tripartite motif-containing 24

Summary

GENCODE gene_type=protein_coding; HGNC symbol=TRIM24; HGNC name=tripartite motif containing 24; alias_count=14; RefSeq=NM_015905; UniProt=O15164; MANE Select=ENST00000343526.9,NM_015905.3

Source: GENCODE + HGNC complete set

8805 • protein-coding

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

O15164 • reviewed

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611)

Transcription intermediary factor 1-alpha · Nucleus; Cytoplasm; Mitochondrion · EC 2.3.2.27

O15164 • reviewed

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611)

Transcription intermediary factor 1-alpha · Nucleus; Cytoplasm; Mitochondrion · EC 2.3.2.27

GO annotations

Biological process
  • GO:0071391 cellular response to estrogen stimulus (IDA)
  • GO:0006325 chromatin organization (IEA)
  • GO:0045893 positive regulation of DNA-templated transcription (IEA)
  • GO:0030163 protein catabolic process (IEA)
  • GO:0030163 protein catabolic process (IMP)
  • GO:0016567 protein ubiquitination (IEA)
  • GO:0016567 protein ubiquitination (IEA)
  • GO:0016567 protein ubiquitination (IEA)
  • GO:0016567 protein ubiquitination (IDA)
  • GO:0042981 regulation of apoptotic process (IMP)

+ 4 more

Cellular component
  • GO:0000785 chromatin (IBA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 20 more

Molecular function
  • GO:0003682 chromatin binding (IEA)
  • GO:0003682 chromatin binding (IDA)
  • GO:0034056 estrogen response element binding (IDA)
  • GO:0140118 histone H3K23ac reader activity (IDA)
  • GO:0016922 nuclear receptor binding (IEA)
  • GO:0002039 p53 binding (IEA)
  • GO:0002039 p53 binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 20 more

Representative

Representative transcript
ENST00000343526
Representative protein
ENSP00000340507.4
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000415680 TRIM24-202 protein_coding not available ENSP00000390829.2 7:138,460,193 - 138,590,023 +
ENST00000883777 TRIM24-207 protein_coding not available ENSP00000553836.1 7:138,460,193 - 138,590,023 +
ENST00000883778 TRIM24-208 protein_coding not available ENSP00000553837.1 7:138,460,193 - 138,590,023 +
ENST00000883779 TRIM24-209 protein_coding not available ENSP00000553838.1 7:138,460,193 - 138,590,023 +
ENST00000883780 TRIM24-210 protein_coding not available ENSP00000553839.1 7:138,460,193 - 138,590,023 +
ENST00000883781 TRIM24-211 protein_coding not available ENSP00000553840.1 7:138,460,193 - 138,590,023 +
ENST00000883782 TRIM24-212 protein_coding not available ENSP00000553841.1 7:138,460,193 - 138,590,023 +
ENST00000883783 TRIM24-213 protein_coding not available ENSP00000553842.1 7:138,460,193 - 138,590,023 +
ENST00000883784 TRIM24-214 protein_coding not available ENSP00000553843.1 7:138,460,193 - 138,590,023 +
ENST00000921874 TRIM24-216 protein_coding not available ENSP00000591933.1 7:138,460,193 - 138,590,023 +
ENST00000921875 TRIM24-217 protein_coding not available ENSP00000591934.1 7:138,460,193 - 138,590,023 +
ENST00000921876 TRIM24-218 protein_coding not available ENSP00000591935.1 7:138,460,193 - 138,590,023 +
ENST00000921877 TRIM24-219 protein_coding not available ENSP00000591936.1 7:138,460,193 - 138,590,023 +
ENST00000921878 TRIM24-220 protein_coding not available ENSP00000591937.1 7:138,460,193 - 138,590,023 +
ENST00000921879 TRIM24-221 protein_coding not available ENSP00000591938.1 7:138,460,193 - 138,590,023 +
ENST00001111041 TRIM24-232 protein_coding not available ENSP00000780846.1 7:138,460,193 - 138,530,227 +
ENST00001111805 TRIM24-233 protein_coding not available ENSP00000781610.1 7:138,460,193 - 138,520,689 +
ENST00001118607 TRIM24-234 protein_coding not available ENSP00000788412.1 7:138,460,193 - 138,520,792 +
ENST00001124258 TRIM24-235 protein_coding not available ENSP00000794063.1 7:138,460,193 - 138,518,930 +
ENST00001141235 TRIM24-236 protein_coding not available ENSP00000807866.1 7:138,460,193 - 138,590,023 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.