Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

TRIAP1

protein_coding 12 120,443,065 - 120,446,415 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000170855

Gene type
protein_coding

Chromosome
12

Coordinates
120,443,065 - 120,446,415

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

51499 CCDS9198 ENST00000546954.2 HSPC132 MDM35 NM_016399 NM_016399.3 O43715 P53CSV WF-1 mitochondrial distribution and morphology 35 homolog (S. cerevisiae) p53-inducible cell-survival factor p53CSV

Summary

GENCODE gene_type=protein_coding; HGNC symbol=TRIAP1; HGNC name=TP53 regulated inhibitor of apoptosis 1; alias_count=13; RefSeq=NM_016399; UniProt=O43715; MANE Select=ENST00000546954.2,NM_016399.3

Source: GENCODE + HGNC complete set

51499 • protein-coding

Alliance of Genome Resources Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic signaling pathway; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

O43715 • reviewed

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003)

TP53-regulated inhibitor of apoptosis 1 · Mitochondrion; Mitochondrion intermembrane space

GO annotations

Biological process

GO:0030330 DNA damage response, signal transduction by p53 class mediator (IDA)
GO:0034644 cellular response to UV (IDA)
GO:0031571 mitotic G1 DNA damage checkpoint signaling (IDA)
GO:0043066 negative regulation of apoptotic process (IMP)
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (IMP)
GO:0090201 negative regulation of release of cytochrome c from mitochondria (IMP)
GO:0015914 phospholipid transport (IDA)
GO:0015914 phospholipid transport (IBA)
GO:2001140 positive regulation of phospholipid transport (IDA)
GO:0045944 positive regulation of transcription by RNA polymerase II (IDA)

+ 2 more

Cellular component

GO:0005758 mitochondrial intermembrane space (IEA)
GO:0005758 mitochondrial intermembrane space (IDA)
GO:0005758 mitochondrial intermembrane space (TAS)
GO:0005758 mitochondrial intermembrane space (TAS)
GO:0005758 mitochondrial intermembrane space (TAS)
GO:0005758 mitochondrial intermembrane space (IBA)
GO:0005739 mitochondrion (IEA)
GO:0005739 mitochondrion (IDA)
GO:0005739 mitochondrion (EXP)
GO:0005739 mitochondrion (HTP)

+ 1 more

Molecular function

GO:0002039 p53 binding (IPI)
GO:1990050 phosphatidic acid transfer activity (IDA)
GO:1990050 phosphatidic acid transfer activity (IDA)
GO:1990050 phosphatidic acid transfer activity (IBA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 2 more

Representative

Representative transcript
ENST00000546954

Representative protein
ENSP00000449795.1

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00001143186	TRIAP1-207	protein_coding	not available	ENSP00000814062.1	12:120,443,065 - 120,446,415 -
ENST00000932578	TRIAP1-203	protein_coding	not available	ENSP00000602637.1	12:120,443,958 - 120,446,415 -
ENST00001098103	TRIAP1-204	protein_coding	not available	ENSP00000767909.1	12:120,443,961 - 120,446,415 -
ENST00000546954	TRIAP1-202	protein_coding	not available	ENSP00000449795.1	12:120,443,964 - 120,446,384 -
ENST00001125440	TRIAP1-206	protein_coding	not available	ENSP00000795245.1	12:120,443,964 - 120,446,415 -
ENST00001120904	TRIAP1-205	protein_coding	not available	ENSP00000790709.1	12:120,443,965 - 120,446,415 -
ENST00000302432	TRIAP1-201	protein_coding_CDS_not_defined	not available	not available	12:120,444,208 - 120,446,370 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.