Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

TREX2

TREX2

protein_coding X 153,444,473 - 153,470,592 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000183479

Gene type
protein_coding

Chromosome
X

Coordinates
153,444,473 - 153,470,592

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

11219 CCDS35437 ENST00000370231.3 NM_080701 NM_080701.4 Q9BQ50

Summary

GENCODE gene_type=protein_coding; HGNC symbol=TREX2; HGNC name=three prime repair exonuclease 2; alias_count=6; RefSeq=NM_080701; UniProt=Q9BQ50; MANE Select=ENST00000370231.3,NM_080701.4

Source: GENCODE + HGNC complete set

11219 • protein-coding

This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

NCBI Gene

UniProt

Q9BQ50 • reviewed

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair

Three prime repair exonuclease 2 · Nucleus · EC 3.1.11.2

Q9BQ50 • reviewed

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair

Three prime repair exonuclease 2 · Nucleus · EC 3.1.11.2

Q9BQ50 • reviewed

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair

Three prime repair exonuclease 2 · Nucleus · EC 3.1.11.2

Q9BQ50 • reviewed

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair

Three prime repair exonuclease 2 · Nucleus · EC 3.1.11.2

Q9BQ50 • reviewed

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair

Three prime repair exonuclease 2 · Nucleus · EC 3.1.11.2

Q9BQ50 • reviewed

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair

Three prime repair exonuclease 2 · Nucleus · EC 3.1.11.2

GO annotations

Biological process

GO:0006308 DNA catabolic process (IBA)
GO:0006259 DNA metabolic process (IDA)
GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (TAS)

Cellular component

GO:0005737 cytoplasm (IBA)
GO:0005634 nucleus (IEA)

Molecular function

GO:0008408 3'-5' exonuclease activity (IEA)
GO:0008296 3'-5'-DNA exonuclease activity (IEA)
GO:0008296 3'-5'-DNA exonuclease activity (IDA)
GO:0008296 3'-5'-DNA exonuclease activity (IBA)
GO:0003677 DNA binding (IEA)
GO:0003677 DNA binding (EXP)
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity (IEA)
GO:0000287 magnesium ion binding (IDA)
GO:0060090 molecular adaptor activity (EXP)
GO:0003676 nucleic acid binding (IEA)

+ 2 more

Representative

Representative transcript
ENST00000330912

Representative protein
ENSP00000333441.2

Representative type
CCDS

Candidate count
6

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000330912	TREX2-201	protein_coding	not available	ENSP00000333441.2	X:153,444,473 - 153,470,587 -
ENST00000334497	TREX2-202	protein_coding	not available	ENSP00000334993.2	X:153,444,473 - 153,470,592 -
ENST00000338525	TREX2-203	protein_coding	not available	ENSP00000345218.2	X:153,444,473 - 153,470,587 -
ENST00000370231	TREX2-204	protein_coding	not available	ENSP00000359251.2	X:153,444,473 - 153,446,056 -
ENST00000370232	TREX2-205	protein_coding	not available	ENSP00000359252.1	X:153,444,473 - 153,470,592 -
ENST00000393862	TREX2-206	protein_coding	not available	ENSP00000377442.2	X:153,444,473 - 153,447,863 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.