Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

TP53RK

protein_coding 20 46,684,344 - 46,689,664 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000172315

Gene type
protein_coding

Chromosome
20

Coordinates
46,684,344 - 46,689,664

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

112858 BUD32 C20orf64 CCDS13401 ENST00000372114.4 NM_033550 NM_033550.4 Nori-2p Q96S44 TPRKB chromosome 20 open reading frame 64 dJ101A2.2 p53-related protein kinase prpk

Summary

GENCODE gene_type=protein_coding; HGNC symbol=TP53RK; HGNC name=TP53 regulating kinase; alias_count=14; RefSeq=NM_033550; UniProt=Q96S44; MANE Select=ENST00000372114.4,NM_033550.4

Source: GENCODE + HGNC complete set

112858 • protein-coding

Alliance of Genome Resources Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q96S44 • reviewed

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806)

EKC/KEOPS complex subunit TP53RK · Cytoplasm; Nucleus · EC 2.7.11.1

GO annotations

Biological process

GO:1990145 maintenance of translational fidelity (NAS)
GO:0006468 protein phosphorylation (IDA)
GO:1901796 regulation of signal transduction by p53 class mediator (TAS)
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process (IBA)

Cellular component

GO:0000408 EKC/KEOPS complex (IEA)
GO:0000408 EKC/KEOPS complex (IDA)
GO:0000408 EKC/KEOPS complex (IPI)
GO:0000408 EKC/KEOPS complex (IDA)
GO:0000408 EKC/KEOPS complex (IBA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005829 cytosol (IBA)
GO:0005654 nucleoplasm (TAS)
GO:0005634 nucleus (IEA)

+ 4 more

Molecular function

GO:0005524 ATP binding (IEA)
GO:0003824 catalytic activity (IEA)
GO:0002039 p53 binding (IDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 21 more

Representative

Representative transcript
ENST00000372114

Representative protein
ENSP00000361186.3

Representative type
CCDS

Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000372102	TP53RK-201	protein_coding	not available	ENSP00000361174.3	20:46,684,344 - 46,689,664 -
ENST00001134354	TP53RK-203	protein_coding	not available	ENSP00000809987.1	20:46,684,344 - 46,689,664 -
ENST00000372114	TP53RK-202	protein_coding	not available	ENSP00000361186.3	20:46,684,365 - 46,689,444 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.