Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

TIGAR

protein_coding 12 4,307,763 - 4,360,028 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000078237

Gene type
protein_coding

Chromosome
12

Coordinates
4,307,763 - 4,360,028

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

57103 C12orf5 CCDS8525 ENST00000179259.6 NM_020375 NM_020375.3 Q9NQ88 TP53-induced glycolysis and apoptosis regulator chromosome 12 open reading frame 5

Summary

GENCODE gene_type=protein_coding; HGNC symbol=TIGAR; HGNC name=TP53 induced glycolysis regulatory phosphatase; alias_count=9; RefSeq=NM_020375; UniProt=Q9NQ88; MANE Select=ENST00000179259.6,NM_020375.3

Source: GENCODE + HGNC complete set

57103 • protein-coding

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q9NQ88 • reviewed

Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:22887998, PubMed:23726973, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973)

Fructose-2,6-bisphosphatase TIGAR · Cytoplasm; Nucleus; Mitochondrion · EC 3.1.3.46

GO annotations

Biological process

GO:0006974 DNA damage response (IDA)
GO:0071279 cellular response to cobalt ion (IDA)
GO:0071456 cellular response to hypoxia (IDA)
GO:0045820 negative regulation of glycolytic process (IBA)
GO:0043069 negative regulation of programmed cell death (IDA)
GO:0045739 positive regulation of DNA repair (IMP)
GO:1903301 positive regulation of hexokinase activity (IDA)
GO:1905857 positive regulation of pentose-phosphate shunt (IEA)
GO:0045937 positive regulation of phosphate metabolic process (IEA)
GO:0043456 regulation of pentose-phosphate shunt (IEA)

+ 7 more

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005737 cytoplasm (IDA)
GO:0005829 cytosol (IDA)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (IBA)
GO:0005741 mitochondrial outer membrane (IDA)
GO:0005739 mitochondrion (IEA)

+ 5 more

Molecular function

GO:0003824 catalytic activity (IEA)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (IEA)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (IEA)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (IEA)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (IEA)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (EXP)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (IDA)
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity (IBA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 4 more

Representative

Representative transcript
ENST00000179259

Representative protein
ENSP00000179259.4

Representative type
CCDS

Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000635110	TIGAR-204	protein_coding	not available	ENSP00000488928.1	12:4,307,763 - 4,360,028 +
ENST00001034559	TIGAR-206	nonsense_mediated_decay	not available	ENSP00000704376.1	12:4,321,193 - 4,354,592 +
ENST00000859882	TIGAR-205	protein_coding	not available	ENSP00000529941.1	12:4,321,199 - 4,360,028 +
ENST00001129175	TIGAR-208	protein_coding	not available	ENSP00000798980.1	12:4,321,199 - 4,331,737 +
ENST00001141892	TIGAR-209	protein_coding	not available	ENSP00000801351.1	12:4,321,199 - 4,360,028 +
ENST00000179259	TIGAR-201	protein_coding	not available	ENSP00000179259.4	12:4,321,213 - 4,360,028 +
ENST00001061827	TIGAR-207	nonsense_mediated_decay	not available	ENSP00000731633.1	12:4,321,217 - 4,353,202 +
ENST00000539671	TIGAR-203	protein_coding_CDS_not_defined	not available	not available	12:4,324,643 - 4,331,318 +
ENST00000537251	TIGAR-202	protein_coding_CDS_not_defined	not available	not available	12:4,335,533 - 4,352,356 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.