Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

SPIDR

SPIDR

protein_coding 8 47,260,568 - 47,737,022 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000164808
Gene type
protein_coding
Chromosome
8
Coordinates
47,260,568 - 47,737,022
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

23514 CCDS43737 CCDS64890 CCDS64891 CCDS87607 ENST00000297423.9 KIAA0146 KIAA0146 NM_001080394 NM_001080394.4 Q14159 scaffolding protein involved in DNA repair

Summary

GENCODE gene_type=protein_coding; HGNC symbol=SPIDR; HGNC name=scaffold protein involved in DNA repair; alias_count=11; RefSeq=NM_001080394; UniProt=Q14159; MANE Select=ENST00000297423.9,NM_001080394.4

Source: GENCODE + HGNC complete set

23514 • protein-coding

Alliance of Genome Resources Involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Located in nuclear chromosome and nucleoplasm. Implicated in ovarian dysgenesis 9. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q14159 • reviewed

Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23509288, PubMed:23754376, PubMed:34253720, PubMed:39169038). As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720, PubMed:39169038). The Shu complex is essential during meiosis by stabilizing DMC1 filaments (PubMed:27967308, PubMed:34697795). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720)

DNA repair-scaffolding protein · Chromosome; Nucleus

Q14159 • reviewed

Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23509288, PubMed:23754376, PubMed:34253720, PubMed:39169038). As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720, PubMed:39169038). The Shu complex is essential during meiosis by stabilizing DMC1 filaments (PubMed:27967308, PubMed:34697795). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720)

DNA repair-scaffolding protein · Chromosome; Nucleus

Q14159 • reviewed

Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23509288, PubMed:23754376, PubMed:34253720, PubMed:39169038). As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720, PubMed:39169038). The Shu complex is essential during meiosis by stabilizing DMC1 filaments (PubMed:27967308, PubMed:34697795). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720)

DNA repair-scaffolding protein · Chromosome; Nucleus

GO annotations

Biological process
  • GO:0006974 DNA damage response (IDA)
  • GO:0000730 DNA recombinase assembly (IDA)
  • GO:0000730 DNA recombinase assembly (IDA)
  • GO:0072757 cellular response to camptothecin (IDA)
  • GO:0072711 cellular response to hydroxyurea (IDA)
  • GO:0071479 cellular response to ionizing radiation (IDA)
  • GO:0071479 cellular response to ionizing radiation (IDA)
  • GO:1990918 double-strand break repair involved in meiotic recombination (IEA)
  • GO:0000724 double-strand break repair via homologous recombination (IEA)
  • GO:0000724 double-strand break repair via homologous recombination (NAS)

+ 12 more

Cellular component
  • GO:0097196 Shu complex (IDA)
  • GO:0097196 Shu complex (NAS)
  • GO:0097196 Shu complex (IDA)
  • GO:0005694 chromosome (IEA)
  • GO:0000228 nuclear chromosome (IDA)
  • GO:0000228 nuclear chromosome (IBA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)

+ 2 more

Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 1 more

Representative

Representative transcript
ENST00000297423
Representative protein
ENSP00000297423.4
Representative type
CCDS
Candidate count
5

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000879677 SPIDR-229 protein_coding not available ENSP00000549736.1 8:47,260,568 - 47,736,306 +
ENST00000936264 SPIDR-230 protein_coding not available ENSP00000606323.1 8:47,260,568 - 47,736,306 +
ENST00001007835 SPIDR-235 protein_coding not available ENSP00000677652.1 8:47,260,568 - 47,735,913 +
ENST00001007836 SPIDR-236 protein_coding not available ENSP00000677653.1 8:47,260,568 - 47,735,913 +
ENST00001007837 SPIDR-237 protein_coding not available ENSP00000677654.1 8:47,260,568 - 47,736,306 +
ENST00001026778 SPIDR-239 protein_coding not available ENSP00000696595.1 8:47,260,568 - 47,736,306 +
ENST00001026779 SPIDR-240 protein_coding not available ENSP00000696596.1 8:47,260,568 - 47,736,306 +
ENST00001026780 SPIDR-241 protein_coding not available ENSP00000696597.1 8:47,260,568 - 47,735,997 +
ENST00001026793 SPIDR-254 protein_coding not available ENSP00000696610.1 8:47,260,568 - 47,736,306 +
ENST00001026794 SPIDR-255 protein_coding not available ENSP00000696611.1 8:47,260,568 - 47,736,306 +
ENST00001026798 SPIDR-259 protein_coding not available ENSP00000696615.1 8:47,260,568 - 47,736,306 +
ENST00001114757 SPIDR-264 protein_coding not available ENSP00000784562.1 8:47,260,568 - 47,674,514 +
ENST00001114758 SPIDR-265 protein_coding not available ENSP00000784563.1 8:47,260,568 - 47,400,792 +
ENST00001116945 SPIDR-266 protein_coding not available ENSP00000786750.1 8:47,260,568 - 47,736,306 +
ENST00001116946 SPIDR-267 protein_coding not available ENSP00000786751.1 8:47,260,568 - 47,495,401 +
ENST00001116947 SPIDR-268 protein_coding not available ENSP00000786752.1 8:47,260,568 - 47,483,996 +
ENST00001116948 SPIDR-269 protein_coding not available ENSP00000786753.1 8:47,260,568 - 47,397,141 +
ENST00001116949 SPIDR-270 protein_coding not available ENSP00000786754.1 8:47,260,568 - 47,314,243 +
ENST00001125441 SPIDR-271 protein_coding not available ENSP00000795246.1 8:47,260,568 - 47,735,911 +
ENST00001125442 SPIDR-272 protein_coding not available ENSP00000795247.1 8:47,260,568 - 47,732,877 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.