Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RYBP

protein_coding 3 72,371,825 - 72,446,621 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000163602

Gene type
protein_coding

Chromosome
3

Coordinates
72,371,825 - 72,446,621

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

23429 AAP1 DEDAF ENST00000643872.4 NM_012234 NM_012234.7 Q8N488 YEAF1 YY1 and E4TF1 associated factor 1 apoptin-associating protein 1 death effector domain-associated factor ring1 interactor RYBP

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RYBP; HGNC name=RING1 and YY1 binding protein; alias_count=12; RefSeq=NM_012234; UniProt=Q8N488; MANE Select=ENST00000643872.4,NM_012234.7

Source: GENCODE + HGNC complete set

23429 • protein-coding

Alliance of Genome Resources Enables nucleic acid binding activity. Involved in chromatin remodeling; positive regulation of apoptotic process; and regulation of primary metabolic process. Located in nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q8N488 • reviewed

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)

RING1 and YY1-binding protein · Nucleus; Cytoplasm; Nucleus, nucleoplasm

GO annotations

Biological process

GO:0006338 chromatin remodeling (IDA)
GO:0031507 heterochromatin formation (NAS)
GO:0045892 negative regulation of DNA-templated transcription (NAS)
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process (IMP)
GO:0045893 positive regulation of DNA-templated transcription (IEA)
GO:0045893 positive regulation of DNA-templated transcription (NAS)
GO:0045893 positive regulation of DNA-templated transcription (IMP)
GO:0043065 positive regulation of apoptotic process (IMP)
GO:0006355 regulation of DNA-templated transcription (IBA)

Cellular component

GO:0035102 PRC1 complex (NAS)
GO:0031519 PcG protein complex (IDA)
GO:0000785 chromatin (NAS)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (EXP)
GO:0005737 cytoplasm (EXP)
GO:0005654 nucleoplasm (IEA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (IEA)
GO:0005654 nucleoplasm (TAS)

+ 8 more

Molecular function

GO:0003677 DNA binding (IEA)
GO:0003677 DNA binding (IBA)
GO:0003676 nucleic acid binding (EXP)
GO:0003676 nucleic acid binding (EXP)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 75 more

Representative

Representative transcript
ENST00000477973

Representative protein
ENSP00000419494.4

Representative type
appris_principal_1

Candidate count
1

GENCODE Release 50 annotation GTF · transcript.tag=appris_principal_1; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000477973	RYBP-201	protein_coding	not available	ENSP00000419494.4	3:72,371,825 - 72,446,621 -
ENST00000676660	RYBP-202	retained_intron	not available	not available	3:72,374,502 - 72,380,630 -
ENST00000677329	RYBP-204	protein_coding_CDS_not_defined	not available	not available	3:72,374,502 - 72,380,359 -
ENST00000676841	RYBP-203	retained_intron	not available	not available	3:72,376,950 - 72,379,197 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.