Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RRM2B

RRM2B

protein_coding 8 102,204,502 - 102,239,382 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000048392

Gene type
protein_coding

Chromosome
8

Coordinates
102,204,502 - 102,239,382

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

50484 CCDS34932 CCDS55267 ENST00000251810.8 NM_001172477 NM_015713.5 Q7LG56 p53R2 ribonucleotide reductase M2 B (TP53 inducible)

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RRM2B; HGNC name=ribonucleotide reductase regulatory TP53 inducible subunit M2B; alias_count=9; RefSeq=NM_001172477; UniProt=Q7LG56; MANE Select=ENST00000251810.8,NM_015713.5

Source: GENCODE + HGNC complete set

50484 • protein-coding

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

NCBI Gene

UniProt

Q7LG56 • reviewed

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage

Ribonucleoside-diphosphate reductase subunit M2 B · Cytoplasm; Nucleus · EC 1.17.4.1

Q7LG56 • reviewed

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage

Ribonucleoside-diphosphate reductase subunit M2 B · Cytoplasm; Nucleus · EC 1.17.4.1

Q7LG56 • reviewed

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage

Ribonucleoside-diphosphate reductase subunit M2 B · Cytoplasm; Nucleus · EC 1.17.4.1

Q7LG56 • reviewed

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage

Ribonucleoside-diphosphate reductase subunit M2 B · Cytoplasm; Nucleus · EC 1.17.4.1

Q7LG56 • reviewed

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage

Ribonucleoside-diphosphate reductase subunit M2 B · Cytoplasm; Nucleus · EC 1.17.4.1

GO annotations

Biological process

GO:0009265 2'-deoxyribonucleotide biosynthetic process (IEA)
GO:0009265 2'-deoxyribonucleotide biosynthetic process (IDA)
GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (IDA)
GO:0000731 DNA synthesis involved in DNA repair (NAS)
GO:0009263 deoxyribonucleotide biosynthetic process (IEA)
GO:0009263 deoxyribonucleotide biosynthetic process (IBA)
GO:0006264 mitochondrial DNA replication (IMP)
GO:0070318 positive regulation of G0 to G1 transition (IEA)
GO:0070318 positive regulation of G0 to G1 transition (IDA)

+ 5 more

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005829 cytosol (IDA)
GO:0005829 cytosol (IDA)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (IBA)
GO:0005739 mitochondrion (IEA)
GO:0005654 nucleoplasm (IDA)
GO:0005634 nucleus (IEA)

Molecular function

GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0016491 oxidoreductase activity (IEA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (IEA)

+ 3 more

Representative

Representative transcript
ENST00000251810

Representative protein
ENSP00000251810.3

Representative type
CCDS

Candidate count
6

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000251810	RRM2B-201	protein_coding	not available	ENSP00000251810.3	8:102,204,502 - 102,238,961 -
ENST00000930763	RRM2B-212	protein_coding	not available	ENSP00000600822.1	8:102,204,502 - 102,239,050 -
ENST00001019577	RRM2B-216	nonsense_mediated_decay	not available	ENSP00000689394.1	8:102,204,502 - 102,239,057 -
ENST00001019578	RRM2B-217	nonsense_mediated_decay	not available	ENSP00000689395.1	8:102,204,502 - 102,239,004 -
ENST00001137340	RRM2B-219	protein_coding	not available	ENSP00000802577.1	8:102,204,502 - 102,239,050 -
ENST00001091370	RRM2B-218	protein_coding	not available	ENSP00000761176.1	8:102,204,624 - 102,239,050 -
ENST00000941786	RRM2B-215	protein_coding	not available	ENSP00000611845.1	8:102,204,626 - 102,239,050 -
ENST00000930764	RRM2B-213	protein_coding	not available	ENSP00000600823.1	8:102,205,615 - 102,239,382 -
ENST00000930765	RRM2B-214	protein_coding	not available	ENSP00000600824.1	8:102,205,699 - 102,239,050 -
ENST00000854932	RRM2B-211	protein_coding	not available	ENSP00000524991.1	8:102,207,090 - 102,239,050 -
ENST00000522368	RRM2B-208	protein_coding	not available	ENSP00000428115.1	8:102,207,745 - 102,238,775 -
ENST00000395910	RRM2B-202	retained_intron	not available	not available	8:102,207,776 - 102,214,229 -
ENST00000395912	RRM2B-203	protein_coding	not available	ENSP00000379248.2	8:102,208,133 - 102,238,874 -
ENST00000519317	RRM2B-206	protein_coding	not available	ENSP00000430641.1	8:102,208,133 - 102,238,874 -
ENST00000519962	RRM2B-207	protein_coding	not available	ENSP00000429140.1	8:102,208,133 - 102,238,874 -
ENST00000522394	RRM2B-209	nonsense_mediated_decay	not available	ENSP00000429578.1	8:102,208,133 - 102,238,874 -
ENST00000519125	RRM2B-205	retained_intron	not available	not available	8:102,212,776 - 102,219,015 -
ENST00000523957	RRM2B-210	nonsense_mediated_decay	not available	ENSP00000427830.1	8:102,224,923 - 102,238,939 -
ENST00000517517	RRM2B-204	retained_intron	not available	not available	8:102,225,975 - 102,238,797 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.