Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RPL23A

protein_coding 17 28,719,940 - 28,724,365 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000198242

Gene type
protein_coding

Chromosome
17

Coordinates
28,719,940 - 28,724,365

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

6147 CCDS11241 ENST00000422514.7 L23A NM_000984 NM_000984.6 P62750 uL23

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RPL23A; HGNC name=ribosomal protein L23a; alias_count=8; RefSeq=NM_000984; UniProt=P62750; MANE Select=ENST00000422514.7,NM_000984.6

Source: GENCODE + HGNC complete set

6147 • protein-coding

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

P62750 • reviewed

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195)

Large ribosomal subunit protein uL23 · Cytoplasm; Nucleus

GO annotations

Biological process

GO:0002181 cytoplasmic translation (IEA)
GO:0002181 cytoplasmic translation (IC)
GO:0002181 cytoplasmic translation (NAS)
GO:1901740 negative regulation of myoblast fusion (NAS)
GO:0007283 spermatogenesis (NAS)
GO:0006941 striated muscle contraction (NAS)
GO:0006412 translation (IEA)
GO:0006412 translation (NAS)
GO:0006412 translation (NAS)

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (HDA)
GO:0005737 cytoplasm (EXP)
GO:0005737 cytoplasm (NAS)
GO:0005737 cytoplasm (EXP)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)

+ 38 more

Molecular function

GO:0003723 RNA binding (HDA)
GO:0003723 RNA binding (HDA)
GO:1904841 TORC2 complex binding (ISS)
GO:1904841 TORC2 complex binding (IEA)
GO:0045296 cadherin binding (HDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 15 more

Representative

Representative transcript
ENST00000422514

Representative protein
ENSP00000389103.2

Representative type
CCDS

Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000940449	RPL23A-210	protein_coding	not available	ENSP00000610508.1	17:28,719,940 - 28,724,365 +
ENST00000940450	RPL23A-211	protein_coding	not available	ENSP00000610509.1	17:28,719,940 - 28,724,365 +
ENST00001072309	RPL23A-212	protein_coding	not available	ENSP00000742115.1	17:28,719,940 - 28,724,365 +
ENST00001093594	RPL23A-216	protein_coding	not available	ENSP00000763400.1	17:28,719,940 - 28,723,938 +
ENST00001093595	RPL23A-217	protein_coding	not available	ENSP00000763401.1	17:28,719,940 - 28,724,365 +
ENST00001093596	RPL23A-218	protein_coding	not available	ENSP00000763402.1	17:28,719,940 - 28,723,938 +
ENST00001093599	RPL23A-221	protein_coding	not available	ENSP00000763405.1	17:28,719,940 - 28,724,365 +
ENST00001093601	RPL23A-223	protein_coding	not available	ENSP00000763407.1	17:28,719,940 - 28,724,365 +
ENST00001093602	RPL23A-224	protein_coding	not available	ENSP00000763408.1	17:28,719,940 - 28,724,365 +
ENST00001141658	RPL23A-226	protein_coding	not available	ENSP00000812513.1	17:28,719,940 - 28,724,365 +
ENST00001093593	RPL23A-215	nonsense_mediated_decay	not available	ENSP00000763399.1	17:28,719,952 - 28,724,365 +
ENST00000422514	RPL23A-204	protein_coding	not available	ENSP00000389103.2	17:28,719,985 - 28,724,359 +
ENST00000582736	RPL23A-209	retained_intron	not available	not available	17:28,719,991 - 28,721,261 +
ENST00001072314	RPL23A-213	nonsense_mediated_decay	not available	ENSP00000742120.1	17:28,719,991 - 28,723,936 +
ENST00001093597	RPL23A-219	nonsense_mediated_decay	not available	ENSP00000763403.1	17:28,719,991 - 28,723,938 +
ENST00001093598	RPL23A-220	nonsense_mediated_decay	not available	ENSP00000763404.1	17:28,719,993 - 28,723,938 +
ENST00001072315	RPL23A-214	nonsense_mediated_decay	not available	ENSP00000742121.1	17:28,719,994 - 28,723,936 +
ENST00001093600	RPL23A-222	nonsense_mediated_decay	not available	ENSP00000763406.1	17:28,719,994 - 28,723,938 +
ENST00001093603	RPL23A-225	nonsense_mediated_decay	not available	ENSP00000763409.1	17:28,719,995 - 28,723,934 +
ENST00000496182	RPL23A-206	protein_coding	not available	ENSP00000468172.1	17:28,720,079 - 28,724,365 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.