Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RPA4

protein_coding X 96,883,908 - 96,885,467 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000204086

Gene type
protein_coding

Chromosome
X

Coordinates
96,883,908 - 96,885,467

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

29935 CCDS35345 ENST00000373040.4 HSU24186 NM_013347 NM_013347.4 Q13156 replication protein A4, 30kDa replication protein A4, 34kDa

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RPA4; HGNC name=replication protein A4; alias_count=10; RefSeq=NM_013347; UniProt=Q13156; MANE Select=ENST00000373040.4,NM_013347.4

Source: GENCODE + HGNC complete set

29935 • protein-coding

This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]

NCBI Gene

UniProt

Q13156 • reviewed

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange

Replication protein A 30 kDa subunit · Nucleus

GO annotations

Biological process

GO:0000077 DNA damage checkpoint signaling (IEA)
GO:0000077 DNA damage checkpoint signaling (IDA)
GO:0006310 DNA recombination (IEA)
GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (IDA)
GO:0006260 DNA replication (IEA)
GO:0006260 DNA replication (IEA)
GO:0006260 DNA replication (IBA)
GO:0006270 DNA replication initiation (TAS)
GO:0000724 double-strand break repair via homologous recombination (IBA)

+ 5 more

Cellular component

GO:0005662 DNA replication factor A complex (IEA)
GO:0005662 DNA replication factor A complex (IDA)
GO:0005662 DNA replication factor A complex (IPI)
GO:0005662 DNA replication factor A complex (TAS)
GO:0005662 DNA replication factor A complex (IBA)
GO:0000781 chromosome, telomeric region (IBA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IEA)

+ 2 more

Molecular function

GO:0003677 DNA binding (IEA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0003697 single-stranded DNA binding (TAS)
GO:0003697 single-stranded DNA binding (IBA)

+ 1 more

Representative

Representative transcript
ENST00000373040

Representative protein
ENSP00000362131.3

Representative type
CCDS

Candidate count
1

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=NA

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000373040	RPA4-201	protein_coding	not available	ENSP00000362131.3	X:96,883,908 - 96,885,467 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.