Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RPA3

RPA3

protein_coding 7 7,634,843 - 7,718,607 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000106399
Gene type
protein_coding
Chromosome
7
Coordinates
7,634,843 - 7,718,607
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

6119 CCDS5356 ENST00000223129.8 NM_002947 NM_002947.5 P35244 REPA3 replication protein A3 (14kD) replication protein A3, 14kDa

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RPA3; HGNC name=replication protein A3; alias_count=10; RefSeq=NM_002947; UniProt=P35244; MANE Select=ENST00000223129.8,NM_002947.5

Source: GENCODE + HGNC complete set

6119 • protein-coding

Alliance of Genome Resources Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA metabolic process. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

P35244 • reviewed

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:17596542, PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105)

Replication protein A 14 kDa subunit · Nucleus

P35244 • reviewed

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:17596542, PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105)

Replication protein A 14 kDa subunit · Nucleus

GO annotations

Biological process
  • GO:0006310 DNA recombination (IEA)
  • GO:0006281 DNA repair (IEA)
  • GO:0006281 DNA repair (IDA)
  • GO:0006260 DNA replication (IEA)
  • GO:0006260 DNA replication (IMP)
  • GO:0006260 DNA replication (NAS)
  • GO:0006260 DNA replication (IBA)
  • GO:0006284 base-excision repair (IDA)
  • GO:0006284 base-excision repair (IBA)
  • GO:0000724 double-strand break repair via homologous recombination (IMP)

+ 9 more

Cellular component
  • GO:0005662 DNA replication factor A complex (IDA)
  • GO:0005662 DNA replication factor A complex (IPI)
  • GO:0005662 DNA replication factor A complex (IPI)
  • GO:0005662 DNA replication factor A complex (IBA)
  • GO:0005654 nucleoplasm (IEA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)

+ 79 more

Molecular function
  • GO:0003677 DNA binding (IEA)
  • GO:0003684 damaged DNA binding (IDA)
  • GO:0003684 damaged DNA binding (IBA)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 18 more

Representative

Representative transcript
ENST00000223129
Representative protein
ENSP00000223129.4
Representative type
CCDS
Candidate count
6

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000396682 RPA3-202 protein_coding not available ENSP00000379914.2 7:7,634,843 - 7,641,001 -
ENST00000401447 RPA3-203 protein_coding not available ENSP00000385383.1 7:7,634,843 - 7,640,026 -
ENST00000406109 RPA3-204 protein_coding not available ENSP00000384652.1 7:7,634,843 - 7,640,816 -
ENST00000853923 RPA3-208 protein_coding not available ENSP00000523982.1 7:7,634,843 - 7,640,468 -
ENST00000853924 RPA3-209 protein_coding not available ENSP00000523983.1 7:7,634,843 - 7,640,468 -
ENST00000935607 RPA3-210 protein_coding not available ENSP00000605666.1 7:7,634,843 - 7,641,668 -
ENST00001104680 RPA3-213 protein_coding not available ENSP00000774483.1 7:7,634,843 - 7,640,468 -
ENST00001138969 RPA3-216 protein_coding not available ENSP00000801813.1 7:7,634,843 - 7,718,607 -
ENST00000223129 RPA3-201 protein_coding not available ENSP00000223129.4 7:7,636,518 - 7,718,607 -
ENST00001060400 RPA3-211 nonsense_mediated_decay not available ENSP00000730216.1 7:7,636,716 - 7,640,488 -
ENST00001104679 RPA3-212 nonsense_mediated_decay not available ENSP00000774482.1 7:7,636,716 - 7,640,490 -
ENST00001104682 RPA3-215 nonsense_mediated_decay not available ENSP00000774485.1 7:7,636,925 - 7,640,441 -
ENST00001104681 RPA3-214 protein_coding not available ENSP00000774484.1 7:7,636,947 - 7,640,468 -
ENST00000483031 RPA3-207 retained_intron not available not available 7:7,636,985 - 7,638,406 -
ENST00000462723 RPA3-205 retained_intron not available not available 7:7,638,414 - 7,640,577 -
ENST00000463632 RPA3-206 retained_intron not available not available 7:7,638,579 - 7,640,949 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.