Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RPA2

RPA2

protein_coding 1 27,891,524 - 27,914,751 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000117748
Gene type
protein_coding
Chromosome
1
Coordinates
27,891,524 - 27,914,751
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

6118 CCDS314 CCDS72740 ENST00000373912.8 NM_002946 NM_002946.5 P15927 replication protein A2 (32kD) replication protein A2, 32kDa

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RPA2; HGNC name=replication protein A2; alias_count=10; RefSeq=NM_002946; UniProt=P15927; MANE Select=ENST00000373912.8,NM_002946.5

Source: GENCODE + HGNC complete set

6118 • protein-coding

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

NCBI Gene

UniProt

P15927 • reviewed

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542)

Replication protein A 32 kDa subunit · Nucleus; Nucleus, PML body

P15927 • reviewed

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542)

Replication protein A 32 kDa subunit · Nucleus; Nucleus, PML body

P15927 • reviewed

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542)

Replication protein A 32 kDa subunit · Nucleus; Nucleus, PML body

GO annotations

Biological process
  • GO:0000077 DNA damage checkpoint signaling (IEA)
  • GO:0006310 DNA recombination (IEA)
  • GO:0006281 DNA repair (IEA)
  • GO:0006260 DNA replication (IEA)
  • GO:0006260 DNA replication (IEA)
  • GO:0006260 DNA replication (IDA)
  • GO:0006260 DNA replication (IMP)
  • GO:0006260 DNA replication (NAS)
  • GO:0006260 DNA replication (IBA)
  • GO:0006284 base-excision repair (IDA)

+ 16 more

Cellular component
  • GO:0005662 DNA replication factor A complex (IEA)
  • GO:0005662 DNA replication factor A complex (IDA)
  • GO:0005662 DNA replication factor A complex (IPI)
  • GO:0005662 DNA replication factor A complex (IDA)
  • GO:0005662 DNA replication factor A complex (IDA)
  • GO:0005662 DNA replication factor A complex (IDA)
  • GO:0005662 DNA replication factor A complex (IBA)
  • GO:0016605 PML body (IDA)
  • GO:0016605 PML body (IEA)
  • GO:0016605 PML body (IDA)

+ 92 more

Molecular function
  • GO:0003677 DNA binding (IEA)
  • GO:0003677 DNA binding (IEA)
  • GO:0098505 G-rich strand telomeric DNA binding (IDA)
  • GO:0003684 damaged DNA binding (IDA)
  • GO:0003684 damaged DNA binding (IDA)
  • GO:0003684 damaged DNA binding (IDA)
  • GO:0019899 enzyme binding (IPI)
  • GO:0019899 enzyme binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 62 more

Representative

Representative transcript
ENST00000373912
Representative protein
ENSP00000363021.3
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000313433 RPA2-201 protein_coding not available ENSP00000363015.3 1:27,891,524 - 27,914,513 -
ENST00000373909 RPA2-202 protein_coding not available ENSP00000363017.3 1:27,891,524 - 27,914,751 -
ENST00000373912 RPA2-203 protein_coding not available ENSP00000363021.3 1:27,891,524 - 27,914,575 -
ENST00000882504 RPA2-206 protein_coding not available ENSP00000552563.1 1:27,891,524 - 27,914,743 -
ENST00000882505 RPA2-207 protein_coding not available ENSP00000552564.1 1:27,891,524 - 27,914,604 -
ENST00000882506 RPA2-208 protein_coding not available ENSP00000552565.1 1:27,891,524 - 27,914,549 -
ENST00000882507 RPA2-209 protein_coding not available ENSP00000552566.1 1:27,891,524 - 27,914,549 -
ENST00000935485 RPA2-210 protein_coding not available ENSP00000605544.1 1:27,891,524 - 27,914,569 -
ENST00000935486 RPA2-211 protein_coding not available ENSP00000605545.1 1:27,891,524 - 27,914,571 -
ENST00001008155 RPA2-212 nonsense_mediated_decay not available ENSP00000677972.1 1:27,891,524 - 27,914,651 -
ENST00001046178 RPA2-213 nonsense_mediated_decay not available ENSP00000715995.1 1:27,891,528 - 27,914,735 -
ENST00001060573 RPA2-218 nonsense_mediated_decay not available ENSP00000730389.1 1:27,891,528 - 27,914,575 -
ENST00001046180 RPA2-215 nonsense_mediated_decay not available ENSP00000715997.1 1:27,891,529 - 27,914,732 -
ENST00001046182 RPA2-217 nonsense_mediated_decay not available ENSP00000715999.1 1:27,891,530 - 27,914,564 -
ENST00001127410 RPA2-219 nonsense_mediated_decay not available ENSP00000797215.1 1:27,891,530 - 27,914,595 -
ENST00001046179 RPA2-214 nonsense_mediated_decay not available ENSP00000715996.1 1:27,891,531 - 27,914,735 -
ENST00001046181 RPA2-216 nonsense_mediated_decay not available ENSP00000715998.1 1:27,891,532 - 27,914,571 -
ENST00000419958 RPA2-204 protein_coding not available ENSP00000413541.1 1:27,891,538 - 27,897,085 -
ENST00000444045 RPA2-205 protein_coding not available ENSP00000387649.1 1:27,897,005 - 27,914,588 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.