Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RAD52

RAD52

protein_coding 12 910,870 - 990,053 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000002016

Gene type
protein_coding

Chromosome
12

Coordinates
910,870 - 990,053

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

5893 CCDS76500 CCDS76501 CCDS8507 ENST00000358495.8 NM_134424 NM_134424.4 P43351 RAD52 (S. cerevisiae) homolog RAD52 homolog (S. cerevisiae) RAD52 homolog, DNA repair protein

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RAD52; HGNC name=RAD52 DNA repair protein; alias_count=12; RefSeq=NM_134424; UniProt=P43351; MANE Select=ENST00000358495.8,NM_134424.4

Source: GENCODE + HGNC complete set

5893 • protein-coding

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

NCBI Gene

UniProt

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

P43351 • reviewed

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

DNA repair protein RAD52 homolog · Nucleus

GO annotations

Biological process

GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing (IDA)
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing (IEA)
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing (IEA)
GO:0000730 DNA recombinase assembly (IEA)
GO:0006310 DNA recombination (IEA)
GO:0006310 DNA recombination (IEA)
GO:0006310 DNA recombination (IMP)
GO:0006310 DNA recombination (IMP)
GO:0006281 DNA repair (IEA)
GO:0034599 cellular response to oxidative stress (IDA)

+ 9 more

Cellular component

GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IDA)

+ 5 more

Molecular function

GO:0003677 DNA binding (IDA)
GO:0003677 DNA binding (TAS)
GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 16 more

Representative

Representative transcript
ENST00000544742

Representative protein
ENSP00000443254.1

Representative type
GENCODE_Primary

Candidate count
11

GENCODE Release 50 annotation GTF · transcript.tag=GENCODE_Primary; transcript_support_level=4

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000430095	RAD52-204	protein_coding	not available	ENSP00000387901.2	12:910,870 - 990,053 -
ENST00000904778	RAD52-220	protein_coding	not available	ENSP00000574837.1	12:910,870 - 949,694 -
ENST00000904779	RAD52-221	protein_coding	not available	ENSP00000574838.1	12:910,870 - 949,694 -
ENST00000904780	RAD52-222	protein_coding	not available	ENSP00000574839.1	12:910,870 - 949,694 -
ENST00000904781	RAD52-223	protein_coding	not available	ENSP00000574840.1	12:910,870 - 949,694 -
ENST00000904782	RAD52-224	protein_coding	not available	ENSP00000574841.1	12:910,870 - 949,694 -
ENST00000928981	RAD52-225	protein_coding	not available	ENSP00000599040.1	12:910,870 - 949,581 -
ENST00000928982	RAD52-226	protein_coding	not available	ENSP00000599041.1	12:910,870 - 949,694 -
ENST00000928983	RAD52-227	protein_coding	not available	ENSP00000599042.1	12:910,870 - 949,694 -
ENST00000952664	RAD52-228	protein_coding	not available	ENSP00000622723.1	12:910,870 - 949,694 -
ENST00000952665	RAD52-229	protein_coding	not available	ENSP00000622724.1	12:910,870 - 949,694 -
ENST00000952666	RAD52-230	protein_coding	not available	ENSP00000622725.1	12:910,870 - 949,694 -
ENST00000952667	RAD52-231	protein_coding	not available	ENSP00000622726.1	12:910,870 - 949,694 -
ENST00001141643	RAD52-237	protein_coding	not available	ENSP00000808665.1	12:910,870 - 949,694 -
ENST00000979337	RAD52-232	nonsense_mediated_decay	not available	ENSP00000649154.1	12:911,025 - 949,694 -
ENST00000358495	RAD52-202	protein_coding	not available	ENSP00000351284.3	12:911,736 - 949,694 -
ENST00000979338	RAD52-233	nonsense_mediated_decay	not available	ENSP00000649155.1	12:912,089 - 949,694 -
ENST00001035066	RAD52-234	nonsense_mediated_decay	not available	ENSP00000704883.1	12:912,089 - 949,677 -
ENST00001060285	RAD52-236	nonsense_mediated_decay	not available	ENSP00000730101.1	12:912,093 - 949,644 -
ENST00000228345	RAD52-201	retained_intron	not available	not available	12:912,155 - 933,076 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.