Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

RAD51AP1

RAD51AP1

protein_coding 12 4,538,775 - 4,560,254 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000111247
Gene type
protein_coding
Chromosome
12
Coordinates
4,538,775 - 4,560,254
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

10635 CCDS44805 CCDS8529 CCDS91640 ENST00000352618.9 NM_006479 NM_006479.5 PIR51 Q96B01

Summary

GENCODE gene_type=protein_coding; HGNC symbol=RAD51AP1; HGNC name=RAD51 associated protein 1; alias_count=9; RefSeq=NM_006479; UniProt=Q96B01; MANE Select=ENST00000352618.9,NM_006479.5

Source: GENCODE + HGNC complete set

10635 • protein-coding

Alliance of Genome Resources Enables DNA binding activity and RNA binding activity. Involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Located in chromatin and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q96B01 • reviewed

Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801)

RAD51-associated protein 1 · Chromosome; Nucleus; Chromosome, telomere

Q96B01 • reviewed

Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801)

RAD51-associated protein 1 · Chromosome; Nucleus; Chromosome, telomere

GO annotations

Biological process
  • GO:0006974 DNA damage response (IDA)
  • GO:0006974 DNA damage response (IDA)
  • GO:0006281 DNA repair (NAS)
  • GO:0006281 DNA repair (TAS)
  • GO:0071479 cellular response to ionizing radiation (IDA)
  • GO:0000724 double-strand break repair via homologous recombination (IMP)
  • GO:0000724 double-strand break repair via homologous recombination (NAS)
  • GO:0000724 double-strand break repair via homologous recombination (IBA)
  • GO:0036297 interstrand cross-link repair (IMP)
  • GO:0036297 interstrand cross-link repair (IBA)

+ 4 more

Cellular component
  • GO:0000785 chromatin (IDA)
  • GO:0005694 chromosome (ISS)
  • GO:0005694 chromosome (IEA)
  • GO:0005694 chromosome (EXP)
  • GO:0005694 chromosome (EXP)
  • GO:0000781 chromosome, telomeric region (IEA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)

+ 16 more

Molecular function
  • GO:0062037 D-loop DNA binding (IDA)
  • GO:0003677 DNA binding (IDA)
  • GO:0000217 DNA secondary structure binding (IDA)
  • GO:0003723 RNA binding (IDA)
  • GO:0003723 RNA binding (TAS)
  • GO:0003690 double-stranded DNA binding (IDA)
  • GO:0003690 double-stranded DNA binding (IDA)
  • GO:0003690 double-stranded DNA binding (IDA)
  • GO:0003690 double-stranded DNA binding (TAS)
  • GO:0003690 double-stranded DNA binding (IBA)

+ 27 more

Representative

Representative transcript
ENST00000228843
Representative protein
ENSP00000228843.9
Representative type
CCDS
Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00001081577 RAD51AP1-221 nonsense_mediated_decay not available ENSP00000751383.1 12:4,538,775 - 4,560,202 +
ENST00000536346 RAD51AP1-207 nonsense_mediated_decay not available ENSP00000443837.1 12:4,538,798 - 4,548,838 +
ENST00001081578 RAD51AP1-222 nonsense_mediated_decay not available ENSP00000751384.1 12:4,538,798 - 4,560,049 +
ENST00000228843 RAD51AP1-201 protein_coding not available ENSP00000228843.9 12:4,538,834 - 4,560,254 +
ENST00000544927 RAD51AP1-213 protein_coding not available ENSP00000446296.1 12:4,538,834 - 4,560,254 +
ENST00000872153 RAD51AP1-215 protein_coding not available ENSP00000542212.1 12:4,538,834 - 4,560,254 +
ENST00000872154 RAD51AP1-216 protein_coding not available ENSP00000542213.1 12:4,538,834 - 4,560,254 +
ENST00000925583 RAD51AP1-217 protein_coding not available ENSP00000595642.1 12:4,538,834 - 4,560,254 +
ENST00000925584 RAD51AP1-218 protein_coding not available ENSP00000595643.1 12:4,538,834 - 4,560,254 +
ENST00000925585 RAD51AP1-219 protein_coding not available ENSP00000595644.1 12:4,538,834 - 4,560,254 +
ENST00000925586 RAD51AP1-220 protein_coding not available ENSP00000595645.1 12:4,538,834 - 4,560,254 +
ENST00001081583 RAD51AP1-226 protein_coding not available ENSP00000751389.1 12:4,538,834 - 4,560,254 +
ENST00001141210 RAD51AP1-231 protein_coding not available ENSP00000806058.1 12:4,538,834 - 4,560,254 +
ENST00001081579 RAD51AP1-223 nonsense_mediated_decay not available ENSP00000751385.1 12:4,538,838 - 4,560,047 +
ENST00001081581 RAD51AP1-225 nonsense_mediated_decay not available ENSP00000751387.1 12:4,538,844 - 4,560,049 +
ENST00001081584 RAD51AP1-227 nonsense_mediated_decay not available ENSP00000751390.1 12:4,538,844 - 4,560,046 +
ENST00001081580 RAD51AP1-224 nonsense_mediated_decay not available ENSP00000751386.1 12:4,538,854 - 4,560,060 +
ENST00001081585 RAD51AP1-228 nonsense_mediated_decay not available ENSP00000751391.1 12:4,538,868 - 4,560,048 +
ENST00000536886 RAD51AP1-208 nonsense_mediated_decay not available ENSP00000438172.1 12:4,538,869 - 4,556,511 +
ENST00000398012 RAD51AP1-203 nonsense_mediated_decay not available ENSP00000439925.1 12:4,538,883 - 4,559,019 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.