Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PWWP3A

PWWP3A

protein_coding 19 1,354,293 - 1,378,434 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000160953
Gene type
protein_coding
Chromosome
19
Coordinates
1,354,293 - 1,378,434
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

84939 CCDS12062 CCDS92480 ENST00000591337.7 EXPAND1 MUM-1 MUM1 NM_001369789.1 NM_032853 Q2TAK8 melanoma associated antigen (mutated) 1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PWWP3A; HGNC name=PWWP domain containing 3A; alias_count=11; RefSeq=NM_032853; UniProt=Q2TAK8; MANE Select=ENST00000591337.7,NM_001369789.1

Source: GENCODE + HGNC complete set

84939 • protein-coding

Alliance of Genome Resources Enables nucleosome binding activity. Involved in DNA repair and chromatin organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q2TAK8 • reviewed

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage

PWWP domain-containing DNA repair factor 3A · Nucleus

Q2TAK8 • reviewed

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage

PWWP domain-containing DNA repair factor 3A · Nucleus

Q2TAK8 • reviewed

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage

PWWP domain-containing DNA repair factor 3A · Nucleus

GO annotations

Biological process
  • GO:0006281 DNA repair (IMP)
  • GO:0006281 DNA repair (IBA)
  • GO:0006325 chromatin organization (IMP)
  • GO:0006325 chromatin organization (IBA)
Cellular component
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (IDA)
  • GO:0005634 nucleus (IBA)
Molecular function
  • GO:0031491 nucleosome binding (IDA)
  • GO:0031491 nucleosome binding (IBA)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000587460
Representative protein
ENSP00000465838.2
Representative type
CCDS
Candidate count
14

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000853246 PWWP3A-218 protein_coding not available ENSP00000523305.1 19:1,354,293 - 1,378,434 +
ENST00000592374 PWWP3A-215 protein_coding not available ENSP00000466891.3 19:1,354,711 - 1,357,094 +
ENST00000590695 PWWP3A-208 retained_intron not available not available 19:1,354,922 - 1,360,631 +
ENST00001038938 PWWP3A-227 nonsense_mediated_decay not available ENSP00000708755.1 19:1,354,943 - 1,378,431 +
ENST00000853247 PWWP3A-219 protein_coding not available ENSP00000523306.1 19:1,354,946 - 1,378,434 +
ENST00000913149 PWWP3A-222 protein_coding not available ENSP00000583208.1 19:1,354,946 - 1,378,434 +
ENST00000913150 PWWP3A-223 protein_coding not available ENSP00000583209.1 19:1,354,946 - 1,378,434 +
ENST00000945202 PWWP3A-224 protein_coding not available ENSP00000615261.1 19:1,354,946 - 1,378,434 +
ENST00000980362 PWWP3A-226 protein_coding not available ENSP00000650179.1 19:1,354,946 - 1,359,916 +
ENST00001127613 PWWP3A-235 protein_coding not available ENSP00000797418.1 19:1,354,946 - 1,378,431 +
ENST00001127614 PWWP3A-236 protein_coding not available ENSP00000797419.1 19:1,354,946 - 1,378,434 +
ENST00001137000 PWWP3A-238 protein_coding not available ENSP00000814370.1 19:1,354,946 - 1,378,434 +
ENST00000591337 PWWP3A-210 protein_coding not available ENSP00000467287.4 19:1,354,959 - 1,378,429 +
ENST00000853248 PWWP3A-220 protein_coding not available ENSP00000523307.1 19:1,354,966 - 1,378,434 +
ENST00000590866 PWWP3A-209 protein_coding_CDS_not_defined not available not available 19:1,354,972 - 1,359,894 +
ENST00000980360 PWWP3A-225 nonsense_mediated_decay not available ENSP00000650177.1 19:1,354,980 - 1,378,431 +
ENST00001084190 PWWP3A-232 nonsense_mediated_decay not available ENSP00000753996.1 19:1,354,980 - 1,378,428 +
ENST00001038939 PWWP3A-228 nonsense_mediated_decay not available ENSP00000708756.1 19:1,354,985 - 1,378,430 +
ENST00001038940 PWWP3A-229 nonsense_mediated_decay not available ENSP00000708757.1 19:1,354,988 - 1,378,428 +
ENST00001084192 PWWP3A-234 nonsense_mediated_decay not available ENSP00000753998.1 19:1,354,988 - 1,376,954 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.