Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PTGES

protein_coding 9 129,738,331 - 129,753,078 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000148344

Gene type
protein_coding

Chromosome
9

Coordinates
129,738,331 - 129,753,078

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

9536 CCDS6927 ENST00000340607.5 MGST-IV MGST1-L1 MGST1-like 1 MGST1L1 NM_004878 NM_004878.5 O14684 PIG12 TP53I12 glutathione S-transferase 1-like 1 mPGES-1 microsomal glutathione S-transferase 1-like 1 microsomal prostaglandin E synthase-1 p53-induced gene 12 tumor protein p53 inducible protein 12

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PTGES; HGNC name=prostaglandin E synthase; alias_count=18; RefSeq=NM_004878; UniProt=O14684; MANE Select=ENST00000340607.5,NM_004878.5

Source: GENCODE + HGNC complete set

9536 • protein-coding

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

O14684 • reviewed

Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824)

Prostaglandin E synthase · Membrane; Cytoplasm, perinuclear region · EC 2.5.1.18; 5.3.99.3

GO annotations

Biological process

GO:0098869 cellular oxidant detoxification (IEA)
GO:0098869 cellular oxidant detoxification (IEA)
GO:0019371 cyclooxygenase pathway (IEA)
GO:0001516 prostaglandin biosynthetic process (IEA)
GO:0001516 prostaglandin biosynthetic process (IEA)
GO:0001516 prostaglandin biosynthetic process (IDA)
GO:0001516 prostaglandin biosynthetic process (IBA)
GO:0006693 prostaglandin metabolic process (TAS)
GO:0031620 regulation of fever generation (ISS)
GO:0031620 regulation of fever generation (IEA)

+ 5 more

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005783 endoplasmic reticulum (IDA)
GO:0005789 endoplasmic reticulum membrane (IEA)
GO:0005789 endoplasmic reticulum membrane (TAS)
GO:0016020 membrane (IEA)
GO:0016020 membrane (IEA)
GO:0016020 membrane (TAS)
GO:0016020 membrane (EXP)
GO:0016020 membrane (IDA)
GO:0016020 membrane (EXP)

+ 3 more

Molecular function

GO:0043295 glutathione binding (IDA)
GO:0004602 glutathione peroxidase activity (IEA)
GO:0004602 glutathione peroxidase activity (IDA)
GO:0004364 glutathione transferase activity (IEA)
GO:0004364 glutathione transferase activity (IEA)
GO:0004364 glutathione transferase activity (IEA)
GO:0004364 glutathione transferase activity (IDA)
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity (IEA)
GO:0004667 prostaglandin-D synthase activity (IEA)
GO:0050220 prostaglandin-E synthase activity (IEA)

+ 28 more

Representative

Representative transcript
ENST00000340607

Representative protein
ENSP00000342385.4

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000481476	PTGES-202	protein_coding_CDS_not_defined	not available	not available	9:129,738,331 - 129,753,019 -
ENST00000340607	PTGES-201	protein_coding	not available	ENSP00000342385.4	9:129,738,349 - 129,753,042 -
ENST00001136918	PTGES-204	protein_coding	not available	ENSP00000807997.1	9:129,738,349 - 129,753,078 -
ENST00001130471	PTGES-203	protein_coding	not available	ENSP00000800276.1	9:129,748,476 - 129,753,078 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.