Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PRMT6

protein_coding 1 107,056,674 - 107,067,636 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000198890

Gene type
protein_coding

Chromosome
1

Coordinates
107,056,674 - 107,067,636

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

55170 CCDS41360 ENST00000370078.2 FLJ10559 HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae) HRMT1L6 NM_018137 NM_018137.3 Q96LA8

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PRMT6; HGNC name=protein arginine methyltransferase 6; alias_count=9; RefSeq=NM_018137; UniProt=Q96LA8; MANE Select=ENST00000370078.2,NM_018137.3

Source: GENCODE + HGNC complete set

55170 • protein-coding

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

NCBI Gene

UniProt

Q96LA8 • reviewed

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18077460, PubMed:18079182). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520)

Protein arginine N-methyltransferase 6 · Nucleus · EC 2.1.1.319

GO annotations

Biological process

GO:0006284 base-excision repair (TAS)
GO:0006338 chromatin remodeling (IDA)
GO:0006338 chromatin remodeling (IBA)
GO:0045892 negative regulation of DNA-templated transcription (IDA)
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process (IEA)
GO:0090068 positive regulation of cell cycle process (IDA)
GO:0006355 regulation of DNA-templated transcription (IBA)
GO:0010468 regulation of gene expression (IEA)
GO:0045652 regulation of megakaryocyte differentiation (TAS)
GO:0010821 regulation of mitochondrion organization (IDA)

Cellular component

GO:0005730 nucleolus (IDA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)

+ 8 more

Molecular function

GO:0003682 chromatin binding (IEA)
GO:0070612 histone H2AR3 methyltransferase activity (IDA)
GO:0140938 histone H3 methyltransferase activity (EXP)
GO:0140938 histone H3 methyltransferase activity (EXP)
GO:0140938 histone H3 methyltransferase activity (TAS)
GO:0070611 histone H3R2 methyltransferase activity (IEA)
GO:0070611 histone H3R2 methyltransferase activity (IEA)
GO:0070611 histone H3R2 methyltransferase activity (IDA)
GO:0070611 histone H3R2 methyltransferase activity (IDA)
GO:0044020 histone H4R3 methyltransferase activity (IDA)

+ 62 more

Representative

Representative transcript
ENST00000370078

Representative protein
ENSP00000359095.1

Representative type
CCDS

Candidate count
1

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=NA

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000370078	PRMT6-201	protein_coding	not available	ENSP00000359095.1	1:107,056,674 - 107,059,294 +
ENST00000650338	PRMT6-203	nonsense_mediated_decay	not available	ENSP00000497826.1	1:107,056,902 - 107,067,636 +
ENST00000649727	PRMT6-202	retained_intron	not available	not available	1:107,057,437 - 107,060,634 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.