Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PPP1R13L

protein_coding 19 45,379,634 - 45,406,367 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000104881

Gene type
protein_coding

Chromosome
19

Coordinates
45,379,634 - 45,406,367

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

10848 CCDS33050 ENST00000360957.10 IASPP NM_006663 NM_006663.4 Q8WUF5 RAI RelA-associated Inhibitor protein phosphatase 1, regulatory (inhibitor) subunit 13 like protein phosphatase 1, regulatory subunit 13 like

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PPP1R13L; HGNC name=protein phosphatase 1 regulatory subunit 13 like; alias_count=12; RefSeq=NM_006663; UniProt=Q8WUF5; MANE Select=ENST00000360957.10,NM_006663.4

Source: GENCODE + HGNC complete set

10848 • protein-coding

OMIM IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

NCBI Gene

UniProt

Q8WUF5 • reviewed

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640)

RelA-associated inhibitor · Cytoplasm; Nucleus

Q8WUF5 • reviewed

RelA-associated inhibitor · Cytoplasm; Nucleus

GO annotations

Biological process

GO:0045892 negative regulation of DNA-templated transcription (IEA)
GO:0050728 negative regulation of inflammatory response (IEA)
GO:0050728 negative regulation of inflammatory response (IMP)
GO:0045597 positive regulation of cell differentiation (IEA)
GO:0045597 positive regulation of cell differentiation (IBA)
GO:0006355 regulation of DNA-templated transcription (IEA)
GO:0006357 regulation of transcription by RNA polymerase II (IBA)

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (EXP)
GO:0005829 cytosol (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (TAS)
GO:0005634 nucleus (EXP)

Molecular function

GO:0045296 cadherin binding (HDA)
GO:0042802 identical protein binding (IPI)
GO:0042802 identical protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 35 more

Representative

Representative transcript
ENST00000360957

Representative protein
ENSP00000354218.4

Representative type
CCDS

Candidate count
9

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000418234	PPP1R13L-202	protein_coding	not available	ENSP00000403902.1	19:45,379,634 - 45,406,367 -
ENST00000863739	PPP1R13L-210	protein_coding	not available	ENSP00000533798.1	19:45,379,634 - 45,406,367 -
ENST00000863740	PPP1R13L-211	protein_coding	not available	ENSP00000533799.1	19:45,379,634 - 45,406,367 -
ENST00000863741	PPP1R13L-212	protein_coding	not available	ENSP00000533800.1	19:45,379,634 - 45,405,066 -
ENST00000863742	PPP1R13L-213	protein_coding	not available	ENSP00000533801.1	19:45,379,634 - 45,405,116 -
ENST00000863743	PPP1R13L-214	protein_coding	not available	ENSP00000533802.1	19:45,379,634 - 45,405,116 -
ENST00000863744	PPP1R13L-215	protein_coding	not available	ENSP00000533803.1	19:45,379,634 - 45,405,014 -
ENST00001140741	PPP1R13L-217	protein_coding	not available	ENSP00000808886.1	19:45,379,634 - 45,405,116 -
ENST00000360957	PPP1R13L-201	protein_coding	not available	ENSP00000354218.4	19:45,379,638 - 45,405,069 -
ENST00000587270	PPP1R13L-204	retained_intron	not available	not available	19:45,379,638 - 45,393,167 -
ENST00000589371	PPP1R13L-205	protein_coding	not available	ENSP00000466555.1	19:45,379,638 - 45,382,592 -
ENST00000591986	PPP1R13L-207	protein_coding	not available	ENSP00000466939.1	19:45,379,638 - 45,385,618 -
ENST00000589858	PPP1R13L-206	retained_intron	not available	not available	19:45,382,564 - 45,386,103 -
ENST00000585905	PPP1R13L-203	retained_intron	not available	not available	19:45,394,653 - 45,406,309 -
ENST00000593226	PPP1R13L-209	protein_coding	not available	ENSP00000466730.1	19:45,396,872 - 45,406,327 -
ENST00001109678	PPP1R13L-216	protein_coding	not available	ENSP00000779483.1	19:45,397,384 - 45,405,116 -
ENST00000592134	PPP1R13L-208	protein_coding	not available	ENSP00000467471.1	19:45,398,023 - 45,405,063 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.