Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PPP1R13B

protein_coding 14 103,733,177 - 103,847,616 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000088808

Gene type
protein_coding

Chromosome
14

Coordinates
103,733,177 - 103,847,616

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

23368 ASPP1 CCDS41997 ENST00000202556.14 KIAA0771 NM_015316 NM_015316.3 Q96KQ4 p53BP2-like p85 protein phosphatase 1, regulatory (inhibitor) subunit 13B protein phosphatase 1, regulatory subunit 13B

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PPP1R13B; HGNC name=protein phosphatase 1 regulatory subunit 13B; alias_count=13; RefSeq=NM_015316; UniProt=Q96KQ4; MANE Select=ENST00000202556.14,NM_015316.3

Source: GENCODE + HGNC complete set

23368 • protein-coding

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q96KQ4 • reviewed

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo

Apoptosis-stimulating of p53 protein 1 · Cytoplasm; Nucleus

GO annotations

Biological process

GO:0006915 apoptotic process (IEA)
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator (IEA)
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator (IDA)
GO:0045786 negative regulation of cell cycle (IEA)
GO:0045786 negative regulation of cell cycle (IEA)
GO:0045786 negative regulation of cell cycle (TAS)
GO:0042981 regulation of apoptotic process (IEA)

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (EXP)
GO:0005737 cytoplasm (TAS)
GO:0005829 cytosol (IDA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)

+ 3 more

Molecular function

GO:0002039 p53 binding (IEA)
GO:0002039 p53 binding (IBA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 68 more

Representative

Representative transcript
ENST00000202556

Representative protein
ENSP00000202556.9

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000869341	PPP1R13B-219	protein_coding	not available	ENSP00000539400.1	14:103,733,177 - 103,847,616 -
ENST00000869342	PPP1R13B-220	protein_coding	not available	ENSP00000539401.1	14:103,733,177 - 103,847,616 -
ENST00000932297	PPP1R13B-221	protein_coding	not available	ENSP00000602356.1	14:103,733,177 - 103,847,616 -
ENST00001135429	PPP1R13B-226	protein_coding	not available	ENSP00000801407.1	14:103,733,177 - 103,847,616 -
ENST00000202556	PPP1R13B-201	protein_coding	not available	ENSP00000202556.9	14:103,733,195 - 103,847,575 -
ENST00000647748	PPP1R13B-218	protein_coding	not available	ENSP00000497343.1	14:103,733,195 - 103,797,488 -
ENST00000557587	PPP1R13B-216	nonsense_mediated_decay	not available	ENSP00000451433.1	14:103,733,752 - 103,737,816 -
ENST00000555825	PPP1R13B-210	retained_intron	not available	not available	14:103,733,753 - 103,737,696 -
ENST00000556597	PPP1R13B-214	nonsense_mediated_decay	not available	ENSP00000451739.1	14:103,733,753 - 103,746,488 -
ENST00000557082	PPP1R13B-215	nonsense_mediated_decay	not available	ENSP00000451396.1	14:103,734,892 - 103,846,885 -
ENST00000555391	PPP1R13B-207	protein_coding_CDS_not_defined	not available	not available	14:103,734,893 - 103,744,015 -
ENST00000556334	PPP1R13B-213	retained_intron	not available	not available	14:103,735,114 - 103,739,272 -
ENST00001115294	PPP1R13B-224	protein_coding	not available	ENSP00000785099.1	14:103,738,159 - 103,847,616 -
ENST00000554432	PPP1R13B-205	retained_intron	not available	not available	14:103,738,389 - 103,739,256 -
ENST00000556325	PPP1R13B-212	protein_coding_CDS_not_defined	not available	not available	14:103,738,679 - 103,847,575 -
ENST00000555991	PPP1R13B-211	protein_coding_CDS_not_defined	not available	not available	14:103,741,992 - 103,747,397 -
ENST00000557744	PPP1R13B-217	retained_intron	not available	not available	14:103,742,089 - 103,742,898 -
ENST00000555183	PPP1R13B-206	protein_coding_CDS_not_defined	not available	not available	14:103,746,374 - 103,747,384 -
ENST00000555708	PPP1R13B-208	protein_coding_CDS_not_defined	not available	not available	14:103,746,708 - 103,747,356 -
ENST00001107849	PPP1R13B-223	nonsense_mediated_decay	not available	ENSP00000777654.1	14:103,747,519 - 103,847,490 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.