Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

POLL

POLL

protein_coding 10 101,576,051 - 101,588,273 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000166169
Gene type
protein_coding
Chromosome
10
Coordinates
101,576,051 - 101,588,273
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

27343 CCDS7513 CCDS76332 ENST00000370162.8 NM_001174084.2 NM_013274 Q9UGP5 polymerase (DNA directed), lambda polymerase (DNA) lambda

Summary

GENCODE gene_type=protein_coding; HGNC symbol=POLL; HGNC name=DNA polymerase lambda; alias_count=10; RefSeq=NM_013274; UniProt=Q9UGP5; MANE Select=ENST00000370162.8,NM_001174084.2

Source: GENCODE + HGNC complete set

27343 • protein-coding

This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]

NCBI Gene

UniProt

Q9UGP5 • reviewed

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195)

DNA polymerase lambda · Nucleus; Chromosome · EC 2.7.7.7

Q9UGP5 • reviewed

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195)

DNA polymerase lambda · Nucleus; Chromosome · EC 2.7.7.7

Q9UGP5 • reviewed

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195)

DNA polymerase lambda · Nucleus; Chromosome · EC 2.7.7.7

Q9UGP5 • reviewed

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195)

DNA polymerase lambda · Nucleus; Chromosome · EC 2.7.7.7

GO annotations

Biological process
  • GO:0071897 DNA biosynthetic process (IDA)
  • GO:0006281 DNA repair (IEA)
  • GO:0006260 DNA replication (NAS)
  • GO:0006287 base-excision repair, gap-filling (IDA)
  • GO:0000724 double-strand break repair via homologous recombination (IMP)
  • GO:0006303 double-strand break repair via nonhomologous end joining (IMP)
  • GO:0006303 double-strand break repair via nonhomologous end joining (IDA)
  • GO:0006303 double-strand break repair via nonhomologous end joining (TAS)
  • GO:0006303 double-strand break repair via nonhomologous end joining (IBA)
  • GO:0006289 nucleotide-excision repair (IDA)

+ 1 more

Cellular component
  • GO:0005694 chromosome (IEA)
  • GO:0005694 chromosome (EXP)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (IEA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (EXP)
  • GO:0005634 nucleus (NAS)

+ 2 more

Molecular function
  • GO:0051575 5'-deoxyribose-5-phosphate lyase activity (IDA)
  • GO:0003677 DNA binding (IEA)
  • GO:0003677 DNA binding (NAS)
  • GO:0034061 DNA polymerase activity (IEA)
  • GO:0034061 DNA polymerase activity (IEA)
  • GO:0034061 DNA polymerase activity (EXP)
  • GO:0034061 DNA polymerase activity (EXP)
  • GO:0034061 DNA polymerase activity (EXP)
  • GO:0034061 DNA polymerase activity (EXP)
  • GO:0034061 DNA polymerase activity (EXP)

+ 40 more

Representative

Representative transcript
ENST00000370172
Representative protein
ENSP00000359191.1
Representative type
GENCODE_Primary
Candidate count
14

GENCODE Release 50 annotation GTF · transcript.tag=GENCODE_Primary; transcript_support_level=2

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000299206 POLL-201 protein_coding not available ENSP00000299206.4 10:101,576,051 - 101,588,270 -
ENST00000339310 POLL-202 protein_coding not available ENSP00000343102.3 10:101,576,051 - 101,588,206 -
ENST00000370168 POLL-204 protein_coding not available ENSP00000359187.3 10:101,576,051 - 101,583,193 -
ENST00000370169 POLL-205 protein_coding not available ENSP00000359188.1 10:101,576,051 - 101,588,206 -
ENST00000370172 POLL-206 protein_coding not available ENSP00000359191.1 10:101,576,051 - 101,588,248 -
ENST00000628479 POLL-217 protein_coding not available ENSP00000485885.1 10:101,576,051 - 101,588,270 -
ENST00000882356 POLL-219 protein_coding not available ENSP00000552415.1 10:101,576,051 - 101,588,273 -
ENST00000882357 POLL-220 protein_coding not available ENSP00000552416.1 10:101,576,051 - 101,588,273 -
ENST00000882358 POLL-221 protein_coding not available ENSP00000552417.1 10:101,576,051 - 101,588,273 -
ENST00000882360 POLL-223 protein_coding not available ENSP00000552419.1 10:101,576,051 - 101,588,273 -
ENST00000882362 POLL-225 protein_coding not available ENSP00000552421.1 10:101,576,051 - 101,588,273 -
ENST00000882363 POLL-226 protein_coding not available ENSP00000552422.1 10:101,576,051 - 101,588,273 -
ENST00000882364 POLL-227 protein_coding not available ENSP00000552423.1 10:101,576,051 - 101,588,273 -
ENST00000882365 POLL-228 protein_coding not available ENSP00000552424.1 10:101,576,051 - 101,588,270 -
ENST00000882366 POLL-229 protein_coding not available ENSP00000552425.1 10:101,576,051 - 101,588,270 -
ENST00000882367 POLL-230 protein_coding not available ENSP00000552426.1 10:101,576,051 - 101,588,257 -
ENST00000937304 POLL-231 protein_coding not available ENSP00000607363.1 10:101,576,051 - 101,588,206 -
ENST00000937305 POLL-232 protein_coding not available ENSP00000607364.1 10:101,576,051 - 101,588,273 -
ENST00000937306 POLL-233 protein_coding not available ENSP00000607365.1 10:101,576,051 - 101,588,257 -
ENST00000937309 POLL-236 protein_coding not available ENSP00000607368.1 10:101,576,051 - 101,588,273 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.