Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PDCD5

protein_coding 19 32,581,062 - 32,587,453 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000105185

Gene type
protein_coding

Chromosome
19

Coordinates
32,581,062 - 32,587,453

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

9141 CCDS12423 ENST00000590247.7 MGC9294 NM_004708 NM_004708.4 O14737 TF1 cell apoptosis-related gene 19 TFAR19 TFAR19 novel apoptosis-related

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PDCD5; HGNC name=programmed cell death 5; alias_count=10; RefSeq=NM_004708; UniProt=O14737; MANE Select=ENST00000590247.7,NM_004708.4

Source: GENCODE + HGNC complete set

9141 • protein-coding

This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

NCBI Gene

UniProt

O14737 • reviewed

In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:19616514, PubMed:22914926, PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling (PubMed:19308289)

Programmed cell death protein 5 · Nucleus; Cytoplasm, cytosol

O14737 • reviewed

Programmed cell death protein 5 · Nucleus; Cytoplasm, cytosol

GO annotations

Biological process

GO:0042110 T cell activation (IPI)
GO:0071560 cellular response to transforming growth factor beta stimulus (IDA)
GO:1903333 negative regulation of protein folding (IMP)
GO:0043065 positive regulation of apoptotic process (IMP)
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator (ISS)
GO:1901798 positive regulation of signal transduction by p53 class mediator (IMP)
GO:1901798 positive regulation of signal transduction by p53 class mediator (IMP)
GO:0042981 regulation of apoptotic process (IMP)

Cellular component

GO:0005737 cytoplasm (HDA)
GO:0005829 cytosol (IEA)
GO:0005829 cytosol (IBA)
GO:0070062 extracellular exosome (HDA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IDA)
GO:0005634 nucleus (IDA)
GO:0005634 nucleus (IDA)
GO:0005634 nucleus (IDA)
GO:0005634 nucleus (IBA)

Molecular function

GO:0003677 DNA binding (IEA)
GO:0010698 acetyltransferase activator activity (IDA)
GO:0048487 beta-tubulin binding (IPI)
GO:0008201 heparin binding (IDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 2 more

Representative

Representative transcript
ENST00000590247

Representative protein
ENSP00000466214.1

Representative type
CCDS

Candidate count
6

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000379316	PDCD5-202	protein_coding	not available	ENSP00000368620.3	19:32,581,062 - 32,587,453 +
ENST00000419343	PDCD5-203	protein_coding	not available	ENSP00000476525.1	19:32,581,062 - 32,587,387 +
ENST00000592786	PDCD5-208	protein_coding	not available	ENSP00000468741.1	19:32,581,062 - 32,587,452 +
ENST00000884500	PDCD5-209	protein_coding	not available	ENSP00000554559.1	19:32,581,062 - 32,587,453 +
ENST00000912659	PDCD5-210	protein_coding	not available	ENSP00000582718.1	19:32,581,062 - 32,587,453 +
ENST00000912660	PDCD5-211	protein_coding	not available	ENSP00000582719.1	19:32,581,062 - 32,587,453 +
ENST00000912661	PDCD5-212	protein_coding	not available	ENSP00000582720.1	19:32,581,062 - 32,587,425 +
ENST00001060070	PDCD5-217	protein_coding	not available	ENSP00000729886.1	19:32,581,062 - 32,587,425 +
ENST00001060077	PDCD5-221	protein_coding	not available	ENSP00000729893.1	19:32,581,062 - 32,587,453 +
ENST00001094654	PDCD5-226	protein_coding	not available	ENSP00000764460.1	19:32,581,062 - 32,587,425 +
ENST00001114980	PDCD5-228	protein_coding	not available	ENSP00000784785.1	19:32,581,062 - 32,587,425 +
ENST00001123445	PDCD5-229	protein_coding	not available	ENSP00000793250.1	19:32,581,062 - 32,587,416 +
ENST00001136705	PDCD5-230	protein_coding	not available	ENSP00000814350.1	19:32,581,062 - 32,587,453 +
ENST00001009102	PDCD5-216	nonsense_mediated_decay	not available	ENSP00000678919.1	19:32,581,139 - 32,587,425 +
ENST00001004809	PDCD5-213	nonsense_mediated_decay	not available	ENSP00000674626.1	19:32,581,164 - 32,587,425 +
ENST00001004810	PDCD5-214	nonsense_mediated_decay	not available	ENSP00000674627.1	19:32,581,169 - 32,587,416 +
ENST00001060071	PDCD5-218	nonsense_mediated_decay	not available	ENSP00000729887.1	19:32,581,180 - 32,587,451 +
ENST00001004811	PDCD5-215	nonsense_mediated_decay	not available	ENSP00000674628.1	19:32,581,184 - 32,587,425 +
ENST00001060072	PDCD5-219	nonsense_mediated_decay	not available	ENSP00000729888.1	19:32,581,184 - 32,587,453 +
ENST00001094653	PDCD5-225	nonsense_mediated_decay	not available	ENSP00000764459.1	19:32,581,187 - 32,587,428 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.