Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

PBK

protein_coding 8 27,809,532 - 27,838,082 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000168078

Gene type
protein_coding

Chromosome
8

Coordinates
27,809,532 - 27,838,082

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

55872 CCDS6063 CCDS64858 CT84 ENST00000301905.9 FLJ14385 NM_018492 NM_018492.4 Nori-3 Q96KB5 SPK T-LAK cell-originated protein kinase TOPK cancer/testis antigen 84

Summary

GENCODE gene_type=protein_coding; HGNC symbol=PBK; HGNC name=PDZ binding kinase; alias_count=14; RefSeq=NM_018492; UniProt=Q96KB5; MANE Select=ENST00000301905.9,NM_018492.4

Source: GENCODE + HGNC complete set

55872 • protein-coding

This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

NCBI Gene

UniProt

Q96KB5 • reviewed

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage

Lymphokine-activated killer T-cell-originated protein kinase · EC 2.7.12.2

Q96KB5 • reviewed

Lymphokine-activated killer T-cell-originated protein kinase · EC 2.7.12.2

GO annotations

Biological process

GO:0000165 MAPK cascade (IEA)
GO:0000278 mitotic cell cycle (NAS)

Cellular component

GO:0005634 nucleus (IDA)

Molecular function

GO:0005524 ATP binding (IEA)
GO:0004708 MAP kinase kinase activity (IEA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 46 more

Representative

Representative transcript
ENST00000301905

Representative protein
ENSP00000301905.4

Representative type
CCDS

Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000522944	PBK-203	protein_coding	not available	ENSP00000428489.1	8:27,809,532 - 27,838,082 -
ENST00000884617	PBK-205	protein_coding	not available	ENSP00000554676.1	8:27,809,532 - 27,838,082 -
ENST00000884618	PBK-206	protein_coding	not available	ENSP00000554677.1	8:27,809,532 - 27,838,061 -
ENST00001139121	PBK-207	protein_coding	not available	ENSP00000805527.1	8:27,809,532 - 27,838,061 -
ENST00000301905	PBK-201	protein_coding	not available	ENSP00000301905.4	8:27,809,624 - 27,837,817 -
ENST00000524266	PBK-204	nonsense_mediated_decay	not available	ENSP00000428438.1	8:27,810,294 - 27,837,783 -
ENST00000521226	PBK-202	protein_coding	not available	ENSP00000427892.2	8:27,820,604 - 27,837,809 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.