Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

NUPR1

NUPR1

protein_coding 16 28,532,708 - 28,539,068 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000176046
Gene type
protein_coding
Chromosome
16
Coordinates
28,532,708 - 28,539,068
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

26471 CCDS10634 CCDS42137 COM1 ENST00000324873.8 NM_012385 NM_012385.3 O60356 candidate of metastasis 1 p8

Summary

GENCODE gene_type=protein_coding; HGNC symbol=NUPR1; HGNC name=nuclear protein 1; alias_count=10; RefSeq=NM_012385; UniProt=O60356; MANE Select=ENST00000324873.8,NM_012385.3

Source: GENCODE + HGNC complete set

26471 • protein-coding

Alliance of Genome Resources Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including negative regulation of programmed cell death; positive regulation of oxidative phosphorylation; and regulation of catabolic process. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2025]

NCBI Gene

UniProt

O60356 • reviewed

Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the association of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity)

Nuclear protein 1 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region

O60356 • reviewed

Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the association of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity)

Nuclear protein 1 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region

GO annotations

Biological process
  • GO:0043066 negative regulation of apoptotic process (IMP)
  • GO:0043066 negative regulation of apoptotic process (IMP)
  • GO:1902902 negative regulation of autophagosome assembly (IMP)
  • GO:0010507 negative regulation of autophagy (ISS)
  • GO:0010507 negative regulation of autophagy (ISS)
  • GO:0010507 negative regulation of autophagy (IEA)
  • GO:0010507 negative regulation of autophagy (IEA)
  • GO:0010507 negative regulation of autophagy (IMP)
  • GO:0010667 negative regulation of cardiac muscle cell apoptotic process (ISS)
  • GO:0010667 negative regulation of cardiac muscle cell apoptotic process (IEA)

+ 28 more

Cellular component
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (IDA)
  • GO:0005634 nucleus (IDA)
  • GO:0005634 nucleus (IBA)
  • GO:0048471 perinuclear region of cytoplasm (IEA)
  • GO:0048471 perinuclear region of cytoplasm (IDA)
  • GO:0032993 protein-DNA complex (IDA)
Molecular function
  • GO:0003677 DNA binding (EXP)
  • GO:0003677 DNA binding (IDA)
  • GO:0003677 DNA binding (IDA)
  • GO:0010698 acetyltransferase activator activity (ISS)
  • GO:0010698 acetyltransferase activator activity (IEA)
  • GO:0003682 chromatin binding (IEA)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 9 more

Representative

Representative transcript
ENST00000324873
Representative protein
ENSP00000315559.7
Representative type
CCDS
Candidate count
6

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000324873 NUPR1-201 protein_coding not available ENSP00000315559.7 16:28,532,708 - 28,538,974 -
ENST00000395641 NUPR1-202 protein_coding not available ENSP00000379003.2 16:28,532,708 - 28,539,038 -
ENST00000876798 NUPR1-204 protein_coding not available ENSP00000546857.1 16:28,532,708 - 28,539,038 -
ENST00000876799 NUPR1-205 protein_coding not available ENSP00000546858.1 16:28,532,708 - 28,539,038 -
ENST00001133426 NUPR1-216 protein_coding not available ENSP00000806440.1 16:28,532,708 - 28,539,038 -
ENST00000962926 NUPR1-206 protein_coding not available ENSP00000632985.1 16:28,537,345 - 28,539,038 -
ENST00000975494 NUPR1-207 nonsense_mediated_decay not available ENSP00000645311.1 16:28,537,345 - 28,538,975 -
ENST00001103353 NUPR1-210 protein_coding not available ENSP00000773156.1 16:28,537,345 - 28,539,038 -
ENST00000975496 NUPR1-209 protein_coding not available ENSP00000645313.1 16:28,537,350 - 28,539,038 -
ENST00001103354 NUPR1-211 nonsense_mediated_decay not available ENSP00000773157.1 16:28,537,366 - 28,538,975 -
ENST00000975495 NUPR1-208 nonsense_mediated_decay not available ENSP00000645312.1 16:28,537,367 - 28,538,992 -
ENST00001121513 NUPR1-213 nonsense_mediated_decay not available ENSP00000791318.1 16:28,537,367 - 28,539,068 -
ENST00001121514 NUPR1-214 nonsense_mediated_decay not available ENSP00000791319.1 16:28,537,367 - 28,539,008 -
ENST00001121515 NUPR1-215 nonsense_mediated_decay not available ENSP00000791320.1 16:28,537,367 - 28,538,974 -
ENST00001103355 NUPR1-212 protein_coding not available ENSP00000773158.1 16:28,537,368 - 28,539,038 -
ENST00000567646 NUPR1-203 nonsense_mediated_decay not available ENSP00000456597.1 16:28,537,507 - 28,538,951 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.