Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

NABP2

protein_coding 12 56,221,978 - 56,229,860 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000139579

Gene type
protein_coding

Chromosome
12

Coordinates
56,221,978 - 56,229,860

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

79035 CCDS8911 ENST00000267023.9 MGC2731 NM_024068 NM_024068.4 OBFC2B Q9BQ15 SOSS-B1 SSB1 hSSB1 oligonucleotide/oligosaccharide-binding fold containing 2B sensor of single-strand DNA complex subunit B1 single strand DNA-binding protein 1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=NABP2; HGNC name=nucleic acid binding protein 2; alias_count=14; RefSeq=NM_024068; UniProt=Q9BQ15; MANE Select=ENST00000267023.9,NM_024068.4

Source: GENCODE + HGNC complete set

79035 • protein-coding

OMIM Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

NCBI Gene

UniProt

Q9BQ15 • reviewed

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways

SOSS complex subunit B1 · Nucleus

Q9BQ15 • reviewed

SOSS complex subunit B1 · Nucleus

Q9BQ15 • reviewed

SOSS complex subunit B1 · Nucleus

GO annotations

Biological process

GO:0006974 DNA damage response (IMP)
GO:0006974 DNA damage response (IMP)
GO:0006281 DNA repair (ISS)
GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (IMP)
GO:0006281 DNA repair (IMP)
GO:0000724 double-strand break repair via homologous recombination (IEA)
GO:0000724 double-strand break repair via homologous recombination (IMP)
GO:0000724 double-strand break repair via homologous recombination (IDA)
GO:0000724 double-strand break repair via homologous recombination (IBA)

+ 11 more

Cellular component

GO:0070876 SOSS complex (IEA)
GO:0070876 SOSS complex (IDA)
GO:0070876 SOSS complex (IDA)
GO:0070876 SOSS complex (IPI)
GO:0070876 SOSS complex (IBA)
GO:0000781 chromosome, telomeric region (IEA)
GO:0000781 chromosome, telomeric region (IDA)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)

+ 8 more

Molecular function

GO:0061730 C-rich strand telomeric DNA binding (IDA)
GO:0003677 DNA binding (IBA)
GO:0070182 DNA polymerase binding (IPI)
GO:0098505 G-rich strand telomeric DNA binding (IDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 4 more

Representative

Representative transcript
ENST00000267023

Representative protein
ENSP00000267023.4

Representative type
CCDS

Candidate count
10

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000882055	NABP2-208	protein_coding	not available	ENSP00000552114.1	12:56,221,978 - 56,229,853 +
ENST00001095816	NABP2-217	protein_coding	not available	ENSP00000765622.1	12:56,221,978 - 56,229,854 +
ENST00000882054	NABP2-207	protein_coding	not available	ENSP00000552113.1	12:56,222,000 - 56,229,853 +
ENST00000934237	NABP2-209	protein_coding	not available	ENSP00000604296.1	12:56,222,000 - 56,229,854 +
ENST00000399713	NABP2-204	protein_coding	not available	ENSP00000408616.1	12:56,222,015 - 56,229,032 +
ENST00000447747	NABP2-205	protein_coding	not available	ENSP00000413902.1	12:56,222,015 - 56,226,416 +
ENST00000959362	NABP2-215	protein_coding	not available	ENSP00000629421.1	12:56,222,905 - 56,229,852 +
ENST00000934238	NABP2-210	protein_coding	not available	ENSP00000604297.1	12:56,223,242 - 56,229,857 +
ENST00000934239	NABP2-211	protein_coding	not available	ENSP00000604298.1	12:56,224,315 - 56,229,859 +
ENST00000934240	NABP2-212	protein_coding	not available	ENSP00000604299.1	12:56,224,315 - 56,229,854 +
ENST00001095817	NABP2-218	protein_coding	not available	ENSP00000765623.1	12:56,224,315 - 56,229,860 +
ENST00001130267	NABP2-222	protein_coding	not available	ENSP00000800072.1	12:56,224,315 - 56,228,223 +
ENST00001136849	NABP2-223	protein_coding	not available	ENSP00000803876.1	12:56,224,315 - 56,229,854 +
ENST00000267023	NABP2-201	protein_coding	not available	ENSP00000267023.4	12:56,224,342 - 56,229,854 +
ENST00000479016	NABP2-206	retained_intron	not available	not available	12:56,224,357 - 56,226,419 +
ENST00000380198	NABP2-203	protein_coding	not available	ENSP00000369545.2	12:56,224,359 - 56,229,854 +
ENST00000934242	NABP2-214	protein_coding	not available	ENSP00000604301.1	12:56,224,359 - 56,229,854 +
ENST00001095818	NABP2-219	protein_coding	not available	ENSP00000765624.1	12:56,224,359 - 56,229,859 +
ENST00001126705	NABP2-221	protein_coding	not available	ENSP00000796510.1	12:56,224,359 - 56,229,855 +
ENST00001041838	NABP2-216	nonsense_mediated_decay	not available	ENSP00000711655.1	12:56,224,395 - 56,229,852 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.