Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

MORC3

protein_coding 21 36,320,180 - 36,386,148 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000159256

Gene type
protein_coding

Chromosome
21

Coordinates
36,320,180 - 36,386,148

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

23515 CCDS42924 ENST00000400485.6 KIAA0136 NM_015358 NM_015358.3 NXP2 Q14149 ZCW5 ZCWCC3 zinc finger, CW type with coiled-coil domain 3 zinc finger, CW-type with coiled-coil domain 3

Summary

GENCODE gene_type=protein_coding; HGNC symbol=MORC3; HGNC name=MORC family CW-type zinc finger 3; alias_count=13; RefSeq=NM_015358; UniProt=Q14149; MANE Select=ENST00000400485.6,NM_015358.3

Source: GENCODE + HGNC complete set

23515 • protein-coding

This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

NCBI Gene

UniProt

Q14149 • reviewed

Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034) (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233)

MORC family CW-type zinc finger protein 3 · Nucleus, nucleoplasm; Nucleus matrix; Nucleus, PML body; Chromosome

GO annotations

Biological process

GO:0140374 antiviral innate immune response (IDA)
GO:0140374 antiviral innate immune response (IBA)
GO:0006325 chromatin organization (IEA)
GO:0051457 maintenance of protein location in nucleus (IDA)
GO:0051457 maintenance of protein location in nucleus (IMP)
GO:0048147 negative regulation of fibroblast proliferation (IDA)
GO:0032688 negative regulation of interferon-beta production (IDA)
GO:0000122 negative regulation of transcription by RNA polymerase II (IDA)
GO:0018105 peptidyl-serine phosphorylation (IDA)
GO:2000774 positive regulation of cellular senescence (IDA)

+ 2 more

Cellular component

GO:0016605 PML body (IDA)
GO:0016605 PML body (IEA)
GO:0016605 PML body (IEA)
GO:0016605 PML body (IDA)
GO:0016605 PML body (IBA)
GO:0000785 chromatin (IDA)
GO:0005694 chromosome (ISS)
GO:0005694 chromosome (IEA)
GO:0016363 nuclear matrix (IEA)
GO:0016363 nuclear matrix (EXP)

+ 7 more

Molecular function

GO:0016887 ATP hydrolysis activity (IEA)
GO:0003677 DNA binding (IDA)
GO:0140002 histone H3K4me3 reader activity (IEA)
GO:0140002 histone H3K4me3 reader activity (IDA)
GO:0140002 histone H3K4me3 reader activity (IBA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 4 more

Representative

Representative transcript
ENST00000400485

Representative protein
ENSP00000383333.1

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000999005	MORC3-213	nonsense_mediated_decay	not available	ENSP00000668822.1	21:36,320,180 - 36,376,638 +
ENST00000492336	MORC3-206	retained_intron	not available	not available	21:36,320,189 - 36,339,527 +
ENST00001010478	MORC3-214	nonsense_mediated_decay	not available	ENSP00000680295.1	21:36,320,196 - 36,376,636 +
ENST00000400485	MORC3-201	protein_coding	not available	ENSP00000383333.1	21:36,320,197 - 36,376,632 +
ENST00001010479	MORC3-215	protein_coding	not available	ENSP00000680296.1	21:36,320,197 - 36,376,635 +
ENST00001120204	MORC3-219	protein_coding	not available	ENSP00000790009.1	21:36,320,197 - 36,360,250 +
ENST00001131669	MORC3-220	protein_coding	not available	ENSP00000812173.1	21:36,320,197 - 36,376,635 +
ENST00001010480	MORC3-216	nonsense_mediated_decay	not available	ENSP00000680297.1	21:36,320,222 - 36,376,632 +
ENST00001112922	MORC3-218	nonsense_mediated_decay	not available	ENSP00000782727.1	21:36,320,224 - 36,378,884 +
ENST00000487909	MORC3-205	protein_coding_CDS_not_defined	not available	not available	21:36,320,231 - 36,376,646 +
ENST00001010482	MORC3-217	nonsense_mediated_decay	not available	ENSP00000680299.1	21:36,320,238 - 36,369,493 +
ENST00000485933	MORC3-204	retained_intron	not available	not available	21:36,333,419 - 36,336,990 +
ENST00000485299	MORC3-203	protein_coding_CDS_not_defined	not available	not available	21:36,347,872 - 36,360,049 +
ENST00000484028	MORC3-202	retained_intron	not available	not available	21:36,361,836 - 36,369,115 +
ENST00000546482	MORC3-207	nonsense_mediated_decay	not available	ENSP00000449467.1	21:36,369,611 - 36,386,148 +
ENST00000547657	MORC3-208	protein_coding_CDS_not_defined	not available	not available	21:36,369,611 - 36,386,148 +
ENST00000549948	MORC3-209	nonsense_mediated_decay	not available	ENSP00000447562.1	21:36,369,611 - 36,386,148 +
ENST00000551367	MORC3-210	protein_coding_CDS_not_defined	not available	not available	21:36,369,611 - 36,386,148 +
ENST00000551788	MORC3-211	nonsense_mediated_decay	not available	ENSP00000448357.1	21:36,369,611 - 36,386,148 +
ENST00000552581	MORC3-212	nonsense_mediated_decay	not available	ENSP00000449966.1	21:36,369,611 - 36,386,148 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.