Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

MDM4

MDM4

protein_coding 1 204,516,369 - 204,558,120 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000198625
Gene type
protein_coding
Chromosome
1
Coordinates
204,516,369 - 204,558,120
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

4194 CCDS1447 CCDS55674 CCDS55675 CCDS60396 CCDS73007 CCDS73008 CCDS73009 ENST00000367182.8 HDMX MDM4, p53 regulator MDMX Mdm4 p53 binding protein homolog (mouse) Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) NM_002393 NM_002393.5 O15151 mouse double minute 4, human homolog of; p53-binding protein

Summary

GENCODE gene_type=protein_coding; HGNC symbol=MDM4; HGNC name=MDM4 regulator of p53; alias_count=22; RefSeq=NM_002393; UniProt=O15151; MANE Select=ENST00000367182.8,NM_002393.5

Source: GENCODE + HGNC complete set

4194 • protein-coding

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

NCBI Gene

UniProt

O15151 • reviewed

Contributes to p53/TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions

Protein Mdm4 · Nucleus; Cytoplasm

O15151 • reviewed

Contributes to p53/TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions

Protein Mdm4 · Nucleus; Cytoplasm

O15151 • reviewed

Contributes to p53/TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions

Protein Mdm4 · Nucleus; Cytoplasm

GO annotations

Biological process
  • GO:0030330 DNA damage response, signal transduction by p53 class mediator (IEP)
  • GO:0003283 atrial septum development (ISS)
  • GO:0003181 atrioventricular valve morphogenesis (ISS)
  • GO:0071456 cellular response to hypoxia (IEP)
  • GO:0003203 endocardial cushion morphogenesis (ISS)
  • GO:0003170 heart valve development (ISS)
  • GO:0045892 negative regulation of DNA-templated transcription (NAS)
  • GO:0045892 negative regulation of DNA-templated transcription (IDA)
  • GO:0045892 negative regulation of DNA-templated transcription (IBA)
  • GO:0043066 negative regulation of apoptotic process (IEA)

+ 13 more

Cellular component
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)

+ 15 more

Molecular function
  • GO:0008047 enzyme activator activity (IDA)
  • GO:0019899 enzyme binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 59 more

Representative

Representative transcript
ENST00000367182
Representative protein
ENSP00000356150.3
Representative type
CCDS
Candidate count
21

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000367183 MDM4-204 protein_coding not available ENSP00000356151.3 1:204,516,369 - 204,558,119 +
ENST00000454264 MDM4-205 protein_coding not available ENSP00000396840.2 1:204,516,369 - 204,558,120 +
ENST00000612738 MDM4-211 protein_coding not available ENSP00000478080.1 1:204,516,369 - 204,558,120 +
ENST00000614459 MDM4-212 protein_coding not available ENSP00000482388.1 1:204,516,369 - 204,558,120 +
ENST00000880814 MDM4-214 protein_coding not available ENSP00000550873.1 1:204,516,369 - 204,558,120 +
ENST00000922675 MDM4-218 protein_coding not available ENSP00000592734.1 1:204,516,369 - 204,558,120 +
ENST00000922676 MDM4-219 protein_coding not available ENSP00000592735.1 1:204,516,369 - 204,558,120 +
ENST00000922678 MDM4-221 protein_coding not available ENSP00000592737.1 1:204,516,369 - 204,558,120 +
ENST00000959566 MDM4-223 protein_coding not available ENSP00000629625.1 1:204,516,369 - 204,558,120 +
ENST00000977380 MDM4-228 protein_coding not available ENSP00000647197.1 1:204,516,369 - 204,527,643 +
ENST00001036955 MDM4-230 nonsense_mediated_decay not available ENSP00000706772.1 1:204,516,369 - 204,549,724 +
ENST00001123221 MDM4-232 protein_coding not available ENSP00000793026.1 1:204,516,369 - 204,537,038 +
ENST00001123222 MDM4-233 protein_coding not available ENSP00000793027.1 1:204,516,369 - 204,535,530 +
ENST00001123223 MDM4-234 protein_coding not available ENSP00000793028.1 1:204,516,369 - 204,534,857 +
ENST00001123224 MDM4-235 protein_coding not available ENSP00000793029.1 1:204,516,369 - 204,534,856 +
ENST00001145865 MDM4-236 protein_coding not available ENSP00000809194.1 1:204,516,369 - 204,558,120 +
ENST00001036954 MDM4-229 nonsense_mediated_decay not available ENSP00000706771.1 1:204,516,371 - 204,551,979 +
ENST00000616250 MDM4-213 nonsense_mediated_decay not available ENSP00000478581.1 1:204,516,379 - 204,558,119 +
ENST00000470797 MDM4-208 retained_intron not available not available 1:204,516,383 - 204,532,650 +
ENST00000977378 MDM4-226 nonsense_mediated_decay not available ENSP00000647195.1 1:204,516,383 - 204,551,999 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.