Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

MCM9

MCM9

protein_coding 6 118,813,260 - 118,935,170 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000111877
Gene type
protein_coding
Chromosome
6
Coordinates
118,813,260 - 118,935,170
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

254394 C6orf61 CCDS5121 CCDS56447 ENST00000619706.5 FLJ20170 MCMDC1 MGC35304 NM_017696.3 NM_153255 Q9NXL9 chromosome 6 open reading frame 61 dJ329L24.3 minichromosome maintenance complex component 9 minichromosome maintenance deficient domain containing 1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=MCM9; HGNC name=minichromosome maintenance 9 homologous recombination repair factor; alias_count=15; RefSeq=NM_153255; UniProt=Q9NXL9; MANE Select=ENST00000619706.5,NM_017696.3

Source: GENCODE + HGNC complete set

254394 • protein-coding

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

NCBI Gene

UniProt

Q9NXL9 • reviewed

Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (PubMed:37309874). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Plays a key role during gametogenesis, probably by regulating HR (By similarity)

DNA helicase MCM9 · Nucleus; Chromosome · EC 5.6.2.4

Q9NXL9 • reviewed

Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (PubMed:37309874). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Plays a key role during gametogenesis, probably by regulating HR (By similarity)

DNA helicase MCM9 · Nucleus; Chromosome · EC 5.6.2.4

Q9NXL9 • reviewed

Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (PubMed:37309874). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Plays a key role during gametogenesis, probably by regulating HR (By similarity)

DNA helicase MCM9 · Nucleus; Chromosome · EC 5.6.2.4

GO annotations

Biological process
  • GO:0006974 DNA damage response (IEA)
  • GO:0006974 DNA damage response (IDA)
  • GO:0006260 DNA replication (IGI)
  • GO:0000724 double-strand break repair via homologous recombination (IEA)
  • GO:0000724 double-strand break repair via homologous recombination (IEA)
  • GO:0000724 double-strand break repair via homologous recombination (IDA)
  • GO:0000724 double-strand break repair via homologous recombination (NAS)
  • GO:0000724 double-strand break repair via homologous recombination (IMP)
  • GO:0000724 double-strand break repair via homologous recombination (IBA)
  • GO:0007292 female gamete generation (ISS)

+ 8 more

Cellular component
  • GO:0042555 MCM complex (IBA)
  • GO:0097362 MCM8-MCM9 complex (IEA)
  • GO:0097362 MCM8-MCM9 complex (IEA)
  • GO:0097362 MCM8-MCM9 complex (IDA)
  • GO:0097362 MCM8-MCM9 complex (IDA)
  • GO:0097362 MCM8-MCM9 complex (IDA)
  • GO:0097362 MCM8-MCM9 complex (IDA)
  • GO:0097362 MCM8-MCM9 complex (IPI)
  • GO:0005694 chromosome (IEA)
  • GO:0005694 chromosome (EXP)

+ 6 more

Molecular function
  • GO:0043138 3'-5' DNA helicase activity (IEA)
  • GO:0043138 3'-5' DNA helicase activity (IDA)
  • GO:0005524 ATP binding (IEA)
  • GO:0016887 ATP hydrolysis activity (IEA)
  • GO:0016887 ATP hydrolysis activity (EXP)
  • GO:0003677 DNA binding (IEA)
  • GO:0003678 DNA helicase activity (IMP)
  • GO:0032406 MutLbeta complex binding (IDA)
  • GO:0032407 MutSalpha complex binding (IDA)
  • GO:0032408 MutSbeta complex binding (IDA)

+ 19 more

Representative

Representative transcript
ENST00000316068
Representative protein
ENSP00000312870.3
Representative type
CCDS
Candidate count
7

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00001019550 MCM9-215 nonsense_mediated_decay not available ENSP00000689367.1 6:118,813,260 - 118,935,117 -
ENST00000316316 MCM9-202 protein_coding not available ENSP00000314505.5 6:118,813,442 - 118,935,170 -
ENST00000877731 MCM9-210 protein_coding not available ENSP00000547790.1 6:118,813,442 - 118,935,170 -
ENST00000877732 MCM9-211 protein_coding not available ENSP00000547791.1 6:118,813,442 - 118,935,170 -
ENST00000962925 MCM9-212 protein_coding not available ENSP00000632984.1 6:118,813,442 - 118,935,139 -
ENST00000983949 MCM9-213 protein_coding not available ENSP00000653766.1 6:118,813,442 - 118,935,170 -
ENST00001141543 MCM9-221 protein_coding not available ENSP00000814672.1 6:118,813,442 - 118,935,159 -
ENST00000619706 MCM9-209 protein_coding not available ENSP00000480469.1 6:118,813,455 - 118,935,159 -
ENST00000983950 MCM9-214 nonsense_mediated_decay not available ENSP00000653767.1 6:118,815,583 - 118,935,138 -
ENST00000458674 MCM9-206 protein_coding not available ENSP00000406576.2 6:118,816,181 - 118,829,253 -
ENST00000505485 MCM9-208 protein_coding_CDS_not_defined not available not available 6:118,828,014 - 118,894,356 -
ENST00000368478 MCM9-203 protein_coding_CDS_not_defined not available not available 6:118,829,028 - 118,894,272 -
ENST00001112610 MCM9-219 protein_coding not available ENSP00000782415.1 6:118,892,529 - 118,935,170 -
ENST00000316068 MCM9-201 protein_coding not available ENSP00000312870.3 6:118,910,597 - 118,935,170 -
ENST00000436788 MCM9-205 retained_intron not available not available 6:118,910,597 - 118,924,052 -
ENST00001085379 MCM9-217 nonsense_mediated_decay not available ENSP00000755185.1 6:118,910,597 - 118,935,160 -
ENST00001085380 MCM9-218 nonsense_mediated_decay not available ENSP00000755186.1 6:118,910,597 - 118,935,129 -
ENST00001019551 MCM9-216 protein_coding not available ENSP00000689368.1 6:118,910,600 - 118,935,139 -
ENST00001112611 MCM9-220 protein_coding not available ENSP00000782416.1 6:118,917,027 - 118,935,170 -
ENST00000425154 MCM9-204 protein_coding not available ENSP00000394776.2 6:118,923,963 - 118,935,024 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.