Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

LIG3

protein_coding 17 34,980,462 - 35,009,743 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000005156

Gene type
protein_coding

Chromosome
17

Coordinates
34,980,462 - 35,009,743

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

3980 CCDS11284 CCDS11285 DNA ligase III ENST00000378526.9 LIG2 LIG3alpha NM_013975 NM_013975.4 P49916 ligase II, DNA, ATP-dependent ligase III, DNA, ATP-dependent

Summary

GENCODE gene_type=protein_coding; HGNC symbol=LIG3; HGNC name=DNA ligase 3; alias_count=14; RefSeq=NM_013975; UniProt=P49916; MANE Select=ENST00000378526.9,NM_013975.4

Source: GENCODE + HGNC complete set

3980 • protein-coding

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

P49916 • reviewed

Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627)

DNA ligase 3 · Mitochondrion; Nucleus · EC 6.5.1.1

P49916 • reviewed

DNA ligase 3 · Mitochondrion; Nucleus · EC 6.5.1.1

GO annotations

Biological process

GO:0071897 DNA biosynthetic process (IEA)
GO:0006310 DNA recombination (IEA)
GO:0006281 DNA repair (IEA)
GO:0033151 V(D)J recombination (IDA)
GO:0006284 base-excision repair (IDA)
GO:0006284 base-excision repair (IMP)
GO:0006287 base-excision repair, gap-filling (TAS)
GO:0006287 base-excision repair, gap-filling (TAS)
GO:0006302 double-strand break repair (IDA)
GO:0006302 double-strand break repair (IBA)

+ 12 more

Cellular component

GO:0070421 DNA ligase III-XRCC1 complex (NAS)
GO:0070421 DNA ligase III-XRCC1 complex (IDA)
GO:0005759 mitochondrial matrix (TAS)
GO:0005739 mitochondrion (IDA)
GO:0005739 mitochondrion (IEA)
GO:0005739 mitochondrion (EXP)
GO:0005739 mitochondrion (IDA)
GO:0005739 mitochondrion (IDA)
GO:0005739 mitochondrion (HTP)
GO:0005654 nucleoplasm (IDA)

+ 21 more

Molecular function

GO:0005524 ATP binding (IEA)
GO:0003677 DNA binding (IEA)
GO:0003910 DNA ligase (ATP) activity (IEA)
GO:0003910 DNA ligase (ATP) activity (IEA)
GO:0003910 DNA ligase (ATP) activity (EXP)
GO:0003910 DNA ligase (ATP) activity (IMP)
GO:0003910 DNA ligase (ATP) activity (EXP)
GO:0003910 DNA ligase (ATP) activity (IDA)
GO:0003910 DNA ligase (ATP) activity (IBA)
GO:0003909 DNA ligase activity (IEA)

+ 15 more

Representative

Representative transcript
ENST00000262327

Representative protein
ENSP00000262327.4

Representative type
CCDS

Candidate count
9

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000262327	LIG3-201	protein_coding	not available	ENSP00000262327.4	17:34,980,462 - 35,003,172 +
ENST00000858900	LIG3-217	protein_coding	not available	ENSP00000528959.1	17:34,980,462 - 35,009,743 +
ENST00000858901	LIG3-218	protein_coding	not available	ENSP00000528960.1	17:34,980,462 - 35,009,743 +
ENST00000932519	LIG3-222	protein_coding	not available	ENSP00000602578.1	17:34,980,462 - 35,009,743 +
ENST00000961393	LIG3-224	protein_coding	not available	ENSP00000631452.1	17:34,980,462 - 35,009,743 +
ENST00000961394	LIG3-225	protein_coding	not available	ENSP00000631453.1	17:34,980,462 - 35,009,743 +
ENST00000961395	LIG3-226	protein_coding	not available	ENSP00000631454.1	17:34,980,462 - 35,009,743 +
ENST00001082757	LIG3-232	protein_coding	not available	ENSP00000752563.1	17:34,980,462 - 35,009,743 +
ENST00001113192	LIG3-235	protein_coding	not available	ENSP00000782997.1	17:34,980,462 - 34,997,938 +
ENST00001138397	LIG3-236	protein_coding	not available	ENSP00000810901.1	17:34,980,462 - 35,009,743 +
ENST00001082753	LIG3-229	nonsense_mediated_decay	not available	ENSP00000752559.1	17:34,980,500 - 35,005,639 +
ENST00001082756	LIG3-231	nonsense_mediated_decay	not available	ENSP00000752562.1	17:34,980,500 - 35,005,067 +
ENST00001082752	LIG3-228	nonsense_mediated_decay	not available	ENSP00000752558.1	17:34,980,509 - 35,009,600 +
ENST00001082754	LIG3-230	nonsense_mediated_decay	not available	ENSP00000752560.1	17:34,980,509 - 35,005,638 +
ENST00001082758	LIG3-233	nonsense_mediated_decay	not available	ENSP00000752564.1	17:34,980,509 - 35,004,800 +
ENST00001082759	LIG3-234	nonsense_mediated_decay	not available	ENSP00000752565.1	17:34,980,509 - 35,004,726 +
ENST00000378526	LIG3-202	protein_coding	not available	ENSP00000367787.3	17:34,980,512 - 35,009,743 +
ENST00000585941	LIG3-205	protein_coding	not available	ENSP00000468479.1	17:34,980,512 - 34,994,429 +
ENST00000858903	LIG3-220	protein_coding	not available	ENSP00000528962.1	17:34,980,512 - 35,009,743 +
ENST00000592690	LIG3-215	protein_coding	not available	ENSP00000467063.1	17:34,980,558 - 34,989,657 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.