Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

LIG1

protein_coding 19 48,115,444 - 48,170,654 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000105486

Gene type
protein_coding

Chromosome
19

Coordinates
48,115,444 - 48,170,654

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

3978 CCDS12711 CCDS74409 CCDS74410 CCDS92657 CCDS92658 DNA ligase I ENST00000263274.12 LIGI NM_000234 NM_000234.3 P18858 hLig1 ligase I, DNA, ATP-dependent

Summary

GENCODE gene_type=protein_coding; HGNC symbol=LIG1; HGNC name=DNA ligase 1; alias_count=16; RefSeq=NM_000234; UniProt=P18858; MANE Select=ENST00000263274.12,NM_000234.3

Source: GENCODE + HGNC complete set

3978 • protein-coding

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

NCBI Gene

UniProt

P18858 • reviewed

DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

DNA ligase 1 · Nucleus · EC 6.5.1.1

P18858 • reviewed

DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

DNA ligase 1 · Nucleus · EC 6.5.1.1

P18858 • reviewed

DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

DNA ligase 1 · Nucleus · EC 6.5.1.1

P18858 • reviewed

DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

DNA ligase 1 · Nucleus · EC 6.5.1.1

GO annotations

Biological process

GO:0071897 DNA biosynthetic process (IEA)
GO:0006310 DNA recombination (IEA)
GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (IEA)
GO:0006281 DNA repair (TAS)
GO:1903461 Okazaki fragment processing involved in mitotic DNA replication (IBA)
GO:0033151 V(D)J recombination (IDA)
GO:0009653 anatomical structure morphogenesis (TAS)
GO:0006284 base-excision repair (IDA)
GO:0006287 base-excision repair, gap-filling (TAS)

+ 4 more

Cellular component

GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)

+ 6 more

Molecular function

GO:0005524 ATP binding (IEA)
GO:0003677 DNA binding (IEA)
GO:0003677 DNA binding (TAS)
GO:0003910 DNA ligase (ATP) activity (IEA)
GO:0003910 DNA ligase (ATP) activity (IEA)
GO:0003910 DNA ligase (ATP) activity (IBA)
GO:0003909 DNA ligase activity (IEA)
GO:0003909 DNA ligase activity (IMP)
GO:0003909 DNA ligase activity (IDA)
GO:0003909 DNA ligase activity (IDA)

+ 6 more

Representative

Representative transcript
ENST00000263274

Representative protein
ENSP00000263274.6

Representative type
CCDS

Candidate count
15

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00001085198	LIG1-272	nonsense_mediated_decay	not available	ENSP00000755004.1	19:48,115,444 - 48,170,356 -
ENST00000263274	LIG1-201	protein_coding	not available	ENSP00000263274.6	19:48,115,445 - 48,170,344 -
ENST00000427526	LIG1-202	protein_coding	not available	ENSP00000442841.1	19:48,115,445 - 48,170,654 -
ENST00000596549	LIG1-211	protein_coding	not available	ENSP00000471861.2	19:48,115,445 - 48,170,654 -
ENST00000699866	LIG1-221	protein_coding	not available	ENSP00000514663.1	19:48,115,445 - 48,170,654 -
ENST00000699868	LIG1-223	protein_coding	not available	ENSP00000514664.1	19:48,115,445 - 48,170,224 -
ENST00000699871	LIG1-226	protein_coding	not available	ENSP00000514667.1	19:48,115,445 - 48,170,654 -
ENST00000699874	LIG1-229	protein_coding	not available	ENSP00000514670.1	19:48,115,445 - 48,170,654 -
ENST00000699875	LIG1-230	protein_coding	not available	ENSP00000514671.1	19:48,115,445 - 48,170,654 -
ENST00000699877	LIG1-232	protein_coding	not available	ENSP00000514672.1	19:48,115,445 - 48,170,654 -
ENST00000884156	LIG1-237	protein_coding	not available	ENSP00000554215.1	19:48,115,445 - 48,170,654 -
ENST00000884157	LIG1-238	protein_coding	not available	ENSP00000554216.1	19:48,115,445 - 48,170,654 -
ENST00000884158	LIG1-239	protein_coding	not available	ENSP00000554217.1	19:48,115,445 - 48,170,654 -
ENST00000884159	LIG1-240	protein_coding	not available	ENSP00000554218.1	19:48,115,445 - 48,170,654 -
ENST00000884160	LIG1-241	protein_coding	not available	ENSP00000554219.1	19:48,115,445 - 48,170,654 -
ENST00000884161	LIG1-242	protein_coding	not available	ENSP00000554220.1	19:48,115,445 - 48,170,654 -
ENST00000884162	LIG1-243	protein_coding	not available	ENSP00000554221.1	19:48,115,445 - 48,170,654 -
ENST00000884164	LIG1-244	protein_coding	not available	ENSP00000554222.1	19:48,115,445 - 48,169,716 -
ENST00000916664	LIG1-245	protein_coding	not available	ENSP00000586723.1	19:48,115,445 - 48,170,654 -
ENST00000916665	LIG1-246	protein_coding	not available	ENSP00000586724.1	19:48,115,445 - 48,170,654 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.