Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

KLF15

protein_coding 3 126,342,635 - 126,357,462 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000163884

Gene type
protein_coding

Chromosome
3

Coordinates
126,342,635 - 126,357,462

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

28999 CCDS3036 ENST00000296233.4 KKLF Kruppel like factor 15 NM_014079 NM_014079.4 Q9UIH9 kidney-enriched Kruppel-like factor

Summary

GENCODE gene_type=protein_coding; HGNC symbol=KLF15; HGNC name=KLF transcription factor 15; alias_count=9; RefSeq=NM_014079; UniProt=Q9UIH9; MANE Select=ENST00000296233.4,NM_014079.4

Source: GENCODE + HGNC complete set

28999 • protein-coding

Alliance of Genome Resources Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q9UIH9 • reviewed

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation

Krueppel-like factor 15 · Nucleus

GO annotations

Biological process

GO:0014898 cardiac muscle hypertrophy in response to stress (IEA)
GO:1990859 cellular response to endothelin (IEA)
GO:0032966 negative regulation of collagen biosynthetic process (IEA)
GO:2000757 negative regulation of peptidyl-lysine acetylation (IMP)
GO:0071635 negative regulation of transforming growth factor beta production (IEA)
GO:0072112 podocyte differentiation (ISS)
GO:0072112 podocyte differentiation (IEA)
GO:0045944 positive regulation of transcription by RNA polymerase II (IMP)
GO:0010468 regulation of gene expression (IEA)
GO:0006357 regulation of transcription by RNA polymerase II (IBA)

Cellular component

GO:0000785 chromatin (ISA)
GO:0016607 nuclear speck (IDA)
GO:0005654 nucleoplasm (IDA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IDA)
GO:0005634 nucleus (IBA)

Molecular function

GO:0003677 DNA binding (IEA)
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific (IMP)
GO:0003700 DNA-binding transcription factor activity (IEA)
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific (ISA)
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding (IDA)
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding (IDA)

+ 51 more

Representative

Representative transcript
ENST00000296233

Representative protein
ENSP00000296233.3

Representative type
CCDS

Candidate count
7

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000296233	KLF15-201	protein_coding	not available	ENSP00000296233.3	3:126,342,635 - 126,357,408 -
ENST00000892073	KLF15-203	protein_coding	not available	ENSP00000562132.1	3:126,342,635 - 126,357,458 -
ENST00000892074	KLF15-204	protein_coding	not available	ENSP00000562133.1	3:126,342,635 - 126,357,462 -
ENST00000892075	KLF15-205	protein_coding	not available	ENSP00000562134.1	3:126,342,635 - 126,357,462 -
ENST00000892076	KLF15-206	protein_coding	not available	ENSP00000562135.1	3:126,342,635 - 126,356,213 -
ENST00000892077	KLF15-207	protein_coding	not available	ENSP00000562136.1	3:126,342,635 - 126,353,888 -
ENST00001138725	KLF15-208	protein_coding	not available	ENSP00000805091.1	3:126,342,635 - 126,357,462 -
ENST00000509675	KLF15-202	protein_coding_CDS_not_defined	not available	not available	3:126,352,675 - 126,354,285 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.