Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

ING1

protein_coding 13 110,712,736 - 110,748,944 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000153487

Gene type
protein_coding

Chromosome
13

Coordinates
110,712,736 - 110,748,944

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

3621 CCDS9515 CCDS9516 CCDS9517 CCDS9518 ENST00000333219.9 NM_005537 NM_198219.3 Q9UK53 growth inhibitor ING1 growth inhibitory protein ING1 inhibitor of growth 1 p24ING1c p33 p33ING1 p33ING1b p47 p47ING1a tumor suppressor ING1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=ING1; HGNC name=inhibitor of growth family member 1; alias_count=19; RefSeq=NM_005537; UniProt=Q9UK53; MANE Select=ENST00000333219.9,NM_198219.3

Source: GENCODE + HGNC complete set

3621 • protein-coding

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q9UK53 • reviewed

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene

Inhibitor of growth protein 1 · Nucleus

Q9UK53 • reviewed

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene

Inhibitor of growth protein 1 · Nucleus

Q9UK53 • reviewed

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene

Inhibitor of growth protein 1 · Nucleus

Q9UK53 • reviewed

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene

Inhibitor of growth protein 1 · Nucleus

GO annotations

Biological process

GO:0006325 chromatin organization (IEA)
GO:0030308 negative regulation of cell growth (NAS)
GO:0030336 negative regulation of cell migration (NAS)
GO:0008285 negative regulation of cell population proliferation (TAS)
GO:1902455 negative regulation of stem cell population maintenance (NAS)
GO:0000122 negative regulation of transcription by RNA polymerase II (NAS)
GO:0000122 negative regulation of transcription by RNA polymerase II (NAS)
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway (NAS)
GO:0045893 positive regulation of DNA-templated transcription (IBA)
GO:1902459 positive regulation of stem cell population maintenance (NAS)

Cellular component

GO:0070822 Sin3-type complex (NAS)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (NAS)
GO:0005634 nucleus (NAS)
GO:0005634 nucleus (IBA)

Molecular function

GO:0140002 histone H3K4me3 reader activity (IEA)
GO:0140002 histone H3K4me3 reader activity (IDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000333219

Representative protein
ENSP00000328436.8

Representative type
CCDS

Candidate count
5

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000338450	ING1-202	protein_coding	not available	ENSP00000345202.7	13:110,712,736 - 110,723,339 +
ENST00000375775	ING1-204	protein_coding	not available	ENSP00000364930.3	13:110,713,253 - 110,723,339 +
ENST00001128094	ING1-209	nonsense_mediated_decay	not available	ENSP00000797899.1	13:110,713,616 - 110,721,073 +
ENST00001128093	ING1-208	protein_coding	not available	ENSP00000797898.1	13:110,713,666 - 110,722,347 +
ENST00000715208	ING1-206	protein_coding	not available	ENSP00000520415.1	13:110,713,670 - 110,723,339 +
ENST00000333219	ING1-201	protein_coding	not available	ENSP00000328436.8	13:110,713,700 - 110,723,339 +
ENST00001101773	ING1-207	nonsense_mediated_decay	not available	ENSP00000771579.1	13:110,714,087 - 110,748,944 +
ENST00000375774	ING1-203	protein_coding	not available	ENSP00000364929.3	13:110,714,982 - 110,723,339 +
ENST00000464141	ING1-205	protein_coding	not available	ENSP00000480985.1	13:110,715,437 - 110,719,476 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.