Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

HROB

HROB

protein_coding 17 44,141,903 - 44,162,481 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000125319
Gene type
protein_coding
Chromosome
17
Coordinates
44,141,903 - 44,162,481
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

78995 C17orf53 CCDS11477 CCDS59293 CCDS82136 ENST00000585683.6 MCM8IP MGC3130 NM_001171251.3 NM_024032 Q8N3J3 chromosome 17 open reading frame 53

Summary

GENCODE gene_type=protein_coding; HGNC symbol=HROB; HGNC name=homologous recombination factor with OB-fold; alias_count=12; RefSeq=NM_024032; UniProt=Q8N3J3; MANE Select=ENST00000585683.6,NM_001171251.3

Source: GENCODE + HGNC complete set

78995 • protein-coding

Alliance of Genome Resources Predicted to enable single-stranded DNA binding activity. Involved in DNA synthesis involved in DNA repair and interstrand cross-link repair. Located in site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q8N3J3 • reviewed

DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis (PubMed:31467087). A C-terminal region including the OB-fold stimulates the helicase activity of MCM8-MCM9 probably by altering its conformation (PubMed:37535404)

Homologous recombination OB-fold protein · Nucleus; Chromosome

Q8N3J3 • reviewed

DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis (PubMed:31467087). A C-terminal region including the OB-fold stimulates the helicase activity of MCM8-MCM9 probably by altering its conformation (PubMed:37535404)

Homologous recombination OB-fold protein · Nucleus; Chromosome

Q8N3J3 • reviewed

DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis (PubMed:31467087). A C-terminal region including the OB-fold stimulates the helicase activity of MCM8-MCM9 probably by altering its conformation (PubMed:37535404)

Homologous recombination OB-fold protein · Nucleus; Chromosome

GO annotations

Biological process
  • GO:0006974 DNA damage response (IMP)
  • GO:0000731 DNA synthesis involved in DNA repair (IMP)
  • GO:0007292 female gamete generation (ISS)
  • GO:0007292 female gamete generation (IEA)
  • GO:0036297 interstrand cross-link repair (IMP)
  • GO:0048232 male gamete generation (ISS)
  • GO:0048232 male gamete generation (IEA)
  • GO:0000725 recombinational repair (IEA)
Cellular component
  • GO:0005694 chromosome (IEA)
  • GO:0005694 chromosome (EXP)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (EXP)
  • GO:0090734 site of DNA damage (IMP)
Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0003697 single-stranded DNA binding (ISS)
  • GO:0003697 single-stranded DNA binding (IEA)

Representative

Representative transcript
ENST00000245382
Representative protein
ENSP00000245382.5
Representative type
CCDS
Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000245382 HROB-201 protein_coding not available ENSP00000245382.5 17:44,141,903 - 44,162,481 +
ENST00000319977 HROB-202 protein_coding not available ENSP00000313500.4 17:44,141,903 - 44,162,481 +
ENST00000910121 HROB-206 protein_coding not available ENSP00000580180.1 17:44,141,903 - 44,162,481 +
ENST00000910122 HROB-207 protein_coding not available ENSP00000580181.1 17:44,141,903 - 44,162,481 +
ENST00000910123 HROB-208 protein_coding not available ENSP00000580182.1 17:44,141,903 - 44,162,481 +
ENST00000910124 HROB-209 protein_coding not available ENSP00000580183.1 17:44,141,903 - 44,162,481 +
ENST00000934733 HROB-210 protein_coding not available ENSP00000604792.1 17:44,141,903 - 44,162,481 +
ENST00000934734 HROB-211 protein_coding not available ENSP00000604793.1 17:44,141,903 - 44,162,481 +
ENST00000934735 HROB-212 protein_coding not available ENSP00000604794.1 17:44,141,903 - 44,162,481 +
ENST00000934736 HROB-213 protein_coding not available ENSP00000604795.1 17:44,141,903 - 44,162,481 +
ENST00000934737 HROB-214 protein_coding not available ENSP00000604796.1 17:44,141,903 - 44,162,481 +
ENST00000934738 HROB-215 protein_coding not available ENSP00000604797.1 17:44,141,903 - 44,162,481 +
ENST00000934739 HROB-216 protein_coding not available ENSP00000604798.1 17:44,141,903 - 44,162,481 +
ENST00000934740 HROB-217 protein_coding not available ENSP00000604799.1 17:44,141,903 - 44,162,481 +
ENST00000934741 HROB-218 protein_coding not available ENSP00000604800.1 17:44,141,903 - 44,162,481 +
ENST00000934742 HROB-219 protein_coding not available ENSP00000604801.1 17:44,141,903 - 44,162,481 +
ENST00000934743 HROB-220 protein_coding not available ENSP00000604802.1 17:44,141,903 - 44,162,481 +
ENST00000934744 HROB-221 protein_coding not available ENSP00000604803.1 17:44,141,903 - 44,162,481 +
ENST00000934745 HROB-222 protein_coding not available ENSP00000604804.1 17:44,141,903 - 44,162,481 +
ENST00000934746 HROB-223 protein_coding not available ENSP00000604805.1 17:44,141,903 - 44,162,481 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.